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Biophysical Journal logoLink to Biophysical Journal
. 2006 Jan 15;90(2):709. doi: 10.1529/biophysj.105.900130

Corrections

PMCID: PMC1367081

Bicho, Ana, and Christof Grewer. 2005. Rapid substrate-induced charge movements of the GABA transporter GAT1. Biophys. J. 89:211–231.

In the Fig. 8 legend, some of the kinetic parameters were not correct. We thank Dr. Donald D. F. Loo for pointing this problem out to us. The correct values are:

k120 = 0.5 M−1 ms−1, k210 = 0.01 ms−1, z12 = 0.9, k230 = 10 M−1 ms−1, k320 = 0.1 ms−1, z23 = 0.3, k340 = 10,000 M−1 ms−1, k430 = 1 ms−1, z34 = 0, k450 = 1 ms−1, k540 = 1 ms−1, z45 = 0.2, k560 = 0.3 ms−1, k650 = 1.5·107 M−3 ms−1, z56 = 0.2, k160 = 0.005 ms−1, k610 = 0.005 ms−1, z61 = −0.8, k670 = 200 M−1 ms−1, k760 = 20 ms−1, z67 = 0.01, k780 = 0.4 ms−1, k870 = 0.02 ms−1, z78 = 0.005, k810 = 50 ms−1, k180 = 10,000 M−1 ms−1, and z81 = −0.215.

These revised kinetic parameters lead to simulations indistinguishable from those shown in Figs. 9 and 10. However, in Fig. 11, the y axis scale has to be multiplied by a factor of ∼10. Finally, it should be noted that the background currents in the simulations before GABA application were subtracted to allow for a better comparison of the simulated currents with the experimental traces.


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