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. 1968 Aug;8(8):951–964. doi: 10.1016/S0006-3495(68)86530-0

Computed Action Potentials for Purkinje Fiber Membranes with Resistance and Capacitance in Series

R Eric McAllister
PMCID: PMC1367383  PMID: 5661902

Abstract

The Hodgkin-Huxley equations, as modified by Noble for computation of Purkinje fiber action potentials, have been solved numerically for a membrane whose equivalent circuit contains a constant resistance in series with part of the capacitance. The rates of depolarization and repolarization of the computed action potential have thereby been brought into agreement with measured values. Possible explanations of the frequently observed pre-plateau notch and of fibrillatory activity arise. The effects of a time-dependent K conductance dependent on the second power of the parameter n, instead of the fourth, have also been considered.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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