Abstract
Theoretical and experimental studies have been made on permeability coefficients to various kinds of electrolyte across lens capsules that are dissected from bovine eyes and that are found to be positively fixed charged membranes from our experiments of membrane potentials. The differential permeability coefficient, Pm, is defined as Js = Pm(C2 - C1), where Js is the flux of an electrolyte component in moles per sec across unit area of the lens capsule that separates two aqueous solutions of the same electrolyte at different concentrations, C2 and C1. Various types of strong electrolytes were studied; KCl, NaCl, Cacl2, MgSO4, MgCl2 and LaCl3. It was found that at C2/C1 = constant, Pm decreases to zero as C2 decreases and Pm increases to a limiting value, (Pm)∞, that is characteristic for the system of the salt used and the membrane as C2 increases, despite of electrolytes. We assumed in theory that single ion activity coefficients of co-ion and gegen-ion are ideal, that the systems studied are in electric neutrality, that the fixed charge density of the membrane is independent of concentrations C2, and that Donnan equilibrium holds between the bulk solution and membrane surface. Although the concentration-dependent changes of Pm were quantitatively different depending on the type of electrolyte used, general agreement between theory and experiment was obtained over a wide range of concentrations except for the case of very dilute solutions.
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