Abstract
The preparation was stimulated externally and transmembrane action potentials were recorded with intracellular microelectrodes. The relationship between the area of the first action potential after a pause in stimulation and the duration of the pause was examined. It was found that the area retained its dependence on the pattern of stimulation prior to the pause. These experiments confirm one of the predictions of a mathematical model (Gibbs et al., 1963) which describes the relationship between the area of action potentials and the pattern of stimulation.
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Selected References
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- GIBBS C. L., JOHNSON E. A., TILLE J. A QUANTITATIVE DESCRIPTION OF THE RELATIONSHIP BETWEEN THE AREA OF RABBIT VENTRICULAR ACTION POTENTIALS AND THE PATTERN OF STIMULATION. Biophys J. 1963 Nov;3:433–458. doi: 10.1016/s0006-3495(63)86830-7. [DOI] [PMC free article] [PubMed] [Google Scholar]