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. 1969 Apr;9(4):510–517. doi: 10.1016/S0006-3495(69)86401-5

Ultraviolet Inactivation and Photoproducts of Transforming DNA Irradiated at Low Temperatures

R O Rahn, Jane K Setlow, J L Hosszu
PMCID: PMC1367534  PMID: 5305089

Abstract

Solutions of Haemophilus influenzae transforming DNA were irradiated at temperatures ranging from 25°C to - 196°C. Temperature dependence of the formation of thymine-containing dimers was closely correlated with inactivation of transforming activity; in general, both dimerization and inactivation decreased with decreasing temperature. The fraction of nonphotoreactivable damage increased with increasing dose at low temperatures. The nonphotoreactivable spore-type photoproduct was formed at low temperatures with a maximum at - 100°C, a temperature at which the nonphotoreactivable biological inactivation was also a maximum. Intrastrand cross-linking, like dimer formation, decreased with decreasing irradiation temperature.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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