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. 1964 Jan;4(1 Pt 2):93–106. doi: 10.1016/s0006-3495(64)86930-7

Metabolism of Collagen in Mammalian Tissues

William van B Robertson
PMCID: PMC1367617  PMID: 14104082

Abstract

The amino acid composition of collagen is described and the status of knowledge about the synthesis of its unique amino acids, hydroxyproline and hydroxylysine, presented. This is followed by a schematic overview of collagen metabolism. Scurvy and lathyrism, the only two abnormalities of collagen metabolism which can now be reasonably elucidated at a molecular level, are then discussed in some detail. The paper concludes by stressing the importance of recognizing the role of histoarchitecture and of interactions of collagen with other compounds when studying collagen or its metabolism in the whole animal.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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