Skip to main content
Biophysical Journal logoLink to Biophysical Journal
. 1969 Nov;9(11):1323–1328. doi: 10.1016/s0006-3495(69)86454-4

Radiosensitivity of Mammalian Cells

III. Effect of Suboptimal Growth Temperatures on Recovery from Radiation-Induced Division Delay

R A Walters, B R Burchill, D F Petersen
PMCID: PMC1367633  PMID: 5389451

Abstract

We investigated the effect of suboptimal growth temperatures on recovery from radiation-induced division delay in Chinese hamster cells. It was found that no recovery occurred during the time that either log-phase or synchronized populations were incubated at 4°C and that injury sustained at low dose rates was cumulative over a period of 6.2 hr at low temperature. Postirradiation conditions influencing recovery from the induced division delay period are different from those affecting survival, suggesting that biochemical damage leading to division delay may be different from that leading to cell death.

Full text

PDF
1323

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dalrymple G. V., Sanders J. L., Baker M. L. Dinitrophenol decreases the radiation sensitivity of L cells. Nature. 1967 Nov 18;216(5116):708–709. doi: 10.1038/216708a0. [DOI] [PubMed] [Google Scholar]
  2. Doida Y., Okada S. Radiation-induced mitotic delay in cultured mammalian cells (L5178Y). Radiat Res. 1969 Jun;38(3):513–529. [PubMed] [Google Scholar]
  3. ELKIND M. M., SUTTON-GILBERT H., MOSES W. B., ALESCIO T., SWAIN R. W. RADIATION RESPONSE OF MAMMALIAN CELLS GROWN IN CULTURE. V. TEMPERATURE DEPENDENCE OF THE REPAIR OF X-RAY DAMAGE IN SURVIVING CELLS (AEROBIC AND HYPOXIC). Radiat Res. 1965 Jun;25:359–376. [PubMed] [Google Scholar]
  4. ELKIND M. M., SUTTON H. Radiation response of mammalian cells grown in culture. 1. Repair of X-ray damage in surviving Chinese hamster cells. Radiat Res. 1960 Oct;13:556–593. [PubMed] [Google Scholar]
  5. Elkind M. M., Moses W. B., Sutton-Gilbert H. Radiation response of mammalian cells grown in culture. VI. Protein, DNA, and RNA inhibition during the repair of x-ray damage. Radiat Res. 1967 May;31(1):156–173. [PubMed] [Google Scholar]
  6. Phillips R. A., Tolmach L. J. Repair of potentially lethal damage in x-irradiated HeLa cells. Radiat Res. 1966 Nov;29(3):413–432. [PubMed] [Google Scholar]
  7. Tobey R. A., Anderson E. C., Petersen D. F. Properties of mitotic cells prepared by mechanically shaking monolayer cultures of Chinese hamster cells. J Cell Physiol. 1967 Aug;70(1):63–68. doi: 10.1002/jcp.1040700109. [DOI] [PubMed] [Google Scholar]
  8. Walters R. A., Petersen D. F. Radiosensitivity of mammalian cells. II. Radiation effects on macromolecular synthesis. Biophys J. 1968 Dec;8(12):1487–1504. doi: 10.1016/S0006-3495(68)86568-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Whitmore G. F., Gulyas S. Studies on recovery processes in mouse L cells. Natl Cancer Inst Monogr. 1967 Feb;24:141–156. [PubMed] [Google Scholar]

Articles from Biophysical Journal are provided here courtesy of The Biophysical Society

RESOURCES