Skip to main content
PMC home page
Biophysical Journal logoLink to Biophysical Journal
. 1970 Jan;10(1):38–54. doi: 10.1016/S0006-3495(70)86284-1

Nonequilibrium-Facilitated Oxygen Transport in Hemoglobin Solution

Howard Kutchai, John A Jacquez, Frances J Mather
PMCID: PMC1367672  PMID: 5409775

Abstract

We have used the quasi-linearization method to obtain numerical solutions to the equations which describe steady-state diffusion of oxygen through layers of hemoglobin solution. The numerical solutions show how the facilitated flux of oxygen depends upon the layer thickness, reaction-rate coefficients, and other parameters of the system. The results indicate that steady-state oxygen diffusion in layers of hemoglobin solution, similar to those studied by Scholander, should be adequately described by the models which assume chemical equilibrium exists throughout the layer, but for layers of concentrated hemoglobin solution about the thickness of a human erythrocyte, the facilitation of oxygen diffusion should be much less than the equilibrium models predict.

Full text

PDF
38

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COLLINS R. E. Transport of gases through hemoglobin solution. Science. 1961 May 19;133(3464):1593–1594. doi: 10.1126/science.133.3464.1593. [DOI] [PubMed] [Google Scholar]
  2. Fox M. A., Landahl H. D. Theory of hemoglobin facilitated oxygen transport. Bull Math Biophys. 1965;27(Suppl):183–190. doi: 10.1007/BF02477275. [DOI] [PubMed] [Google Scholar]
  3. GOERANSSON G. THE METABOLISM OF FATTY ACIDS IN THE RAT. VI. ARACHIDONIC ACID. Acta Physiol Scand. 1965 May-Jun;64:1–5. doi: 10.1111/j.1748-1716.1965.tb04148.x. [DOI] [PubMed] [Google Scholar]
  4. HEMMINGSEN E. A. ENHANCEMENT OF OXYGEN TRANSPORT BY MYOGLOBIN. Comp Biochem Physiol. 1963 Nov;10:239–244. doi: 10.1016/0010-406x(63)90037-9. [DOI] [PubMed] [Google Scholar]
  5. KREUZER F., YAHR W. Z. Influence of red cell membrane on diffusion of oxygen. J Appl Physiol. 1960 Nov;15:1117–1122. doi: 10.1152/jappl.1960.15.6.1117. [DOI] [PubMed] [Google Scholar]
  6. Keller K. H., Friedlander S. K. Diffusivity measurements of human methemoglobin. J Gen Physiol. 1966 Mar;49(4):681–687. doi: 10.1085/jgp.49.4.681. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Keller K. H., Friedlander S. K. The steady-state transport of oxygen through hemoglobin solutions. J Gen Physiol. 1966 Mar;49(4):663–679. doi: 10.1085/jgp.49.4.663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kutchai H., Staub N. C. Steady-state, hemoglobin-facilitated O2 transport in human erythrocytes. J Gen Physiol. 1969 May;53(5):576–589. doi: 10.1085/jgp.53.5.576. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mochizuki M., Forster R. E. Diffusion of Carbon Monoxide through Thin Layers of Hemoglobin Solution. Science. 1962 Nov 23;138(3543):897–898. doi: 10.1126/science.138.3543.897. [DOI] [PubMed] [Google Scholar]
  10. Moll W. Measurements of facilitated diffusion of oxygen in red blood cells at 37 degrees centigrade. Pflugers Arch. 1969;305(3):269–278. doi: 10.1007/BF00587281. [DOI] [PubMed] [Google Scholar]
  11. Moll W. The diffusion coefficient of haemoglobin. Respir Physiol. 1966;1(4):357–365. doi: 10.1016/0034-5687(66)90002-8. [DOI] [PubMed] [Google Scholar]
  12. SCHOLANDER P. F. Oxygen transport through hemoglobin solutions. Science. 1960 Feb 26;131(3400):585–590. doi: 10.1126/science.131.3400.585. [DOI] [PubMed] [Google Scholar]
  13. Snell F. M. Facilitated transport of oxygen through solutions of hemoglobin. J Theor Biol. 1965 May;8(3):469–479. doi: 10.1016/0022-5193(65)90022-6. [DOI] [PubMed] [Google Scholar]
  14. Ward W. J., 3rd, Robb W. L. Carbon dioxide--oxygen separation: facilitated transport of carbon dioxide across a liquid film. Science. 1967 Jun 16;156(3781):1481–1484. doi: 10.1126/science.156.3781.1481. [DOI] [PubMed] [Google Scholar]
  15. Wittenberg J. B. The molecular mechanism of hemoglobin-facilitated oxygen diffusion. J Biol Chem. 1966 Jan 10;241(1):104–114. [PubMed] [Google Scholar]
  16. Wyman J. Facilitated diffusion and the possible role of myoglobin as a transport mechanism. J Biol Chem. 1966 Jan 10;241(1):115–121. [PubMed] [Google Scholar]

Articles from Biophysical Journal are provided here courtesy of The Biophysical Society

RESOURCES