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. 1968 Nov;8(11):1236–1255. doi: 10.1016/S0006-3495(68)86553-1

A Model of Alpha-Helical Distribution in Proteins

John W Prothero
PMCID: PMC1367692  PMID: 5696210

Abstract

It is shown that alpha-helical content of eleven proteins is well correlated with alanine plus leucine content. These residues, taken singly or together, are to a first approximation randomly distributed in the four proteins whose tertiary structures have been determined (i.e., myoglobin, lysozyme, ribonuclease, α-chymotrypsin). A model based on the concept that certain randomly distributed residues specifically participate in helix nucleation is shown to be in reasonable agreement with the presently published structures.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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