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. 1970 Jul;10(7):610–617. doi: 10.1016/S0006-3495(70)86323-8

Sodium Inactivation

Experimental Test of Two Models

Rosalie C Hoyt, William J Adelman Jr
PMCID: PMC1367785  PMID: 5449914

Abstract

Analyses of inactivation experiments performed on unperfused axons of the squid have been compared with the predictions of the Hodgkin-Huxley and the Hoyt mathematical models for the early (sodium) conductance. The results are in good agreement with the latter and in disagreement with the former.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADELMAN W. J., Jr, FOK Y. B. INTERNALLY PERFUSED SQUID AXONS STUDIED UNDER VOLTAGE CLAMP CONDITIONS. II. RESULTS. THE EFFECTS OF INTERNAL POTASSIUM AND SODIUM ON MEMBRANE ELECTRICAL CHARACTERISTICS. J Cell Physiol. 1964 Dec;64:429–443. doi: 10.1002/jcp.1030640315. [DOI] [PubMed] [Google Scholar]
  2. Adelman W. J., Jr, Palti Y. The influence of external potassium on the inactivation of sodium currents in the giant axon of the squid, Loligo pealei. J Gen Physiol. 1969 Jun;53(6):685–703. doi: 10.1085/jgp.53.6.685. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Adelman W. J., Jr, Senft J. P. Dynamic asymmetries in the squid axon membrane. J Gen Physiol. 1968 May;51(5 Suppl):102S+–102S+. [PubMed] [Google Scholar]
  4. Chandler W. K., Meves H. Voltage clamp experiments on internally perfused giant axons. J Physiol. 1965 Oct;180(4):788–820. doi: 10.1113/jphysiol.1965.sp007732. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HODGKIN A. L., HUXLEY A. F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol. 1952 Aug;117(4):500–544. doi: 10.1113/jphysiol.1952.sp004764. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HOYT R. C. THE SQUID GIANT AXON. MATHEMATICAL MODELS. Biophys J. 1963 Sep;3:399–431. doi: 10.1016/s0006-3495(63)86829-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hoyt R. C. Sodium inactivation in nerve fibers. Biophys J. 1968 Oct;8(10):1074–1097. doi: 10.1016/S0006-3495(68)86540-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MULLINS L. J. An analysis of pore size in excitable membranes. J Gen Physiol. 1960 May;43:105–117. doi: 10.1085/jgp.43.5.105. [DOI] [PMC free article] [PubMed] [Google Scholar]

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