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. 1967 Jan;7(1):1–11. doi: 10.1016/S0006-3495(67)86571-8

On Bioelectric Potentials in an Inhomogeneous Volume Conductor

David B Geselowitz
PMCID: PMC1368053  PMID: 19210978

Abstract

Green's theorem is used to derive two sets of expressions for the quasi-static potential distribution in an inhomogeneous volume conductor. The current density in passive regions is assumed to be linearly related instantaneously to the electric field. Two equations are derived relating potentials to an arbitrary distribution of impressed currents. In one, surfaces of discontinuity in electrical conductivity are replaced by double layers and in the other, by surface charges. A multipole equivalent generator is defined and related both to the potential distribution on the outer surface of the volume conductor and to the current sources. An alternative result involves the electric field at the outer surface rather than the potential. Finally, the impressed currents are related to electrical activity at the membranes of active cells. The normal component of membrane current density is assumed to be equal at both membrane surfaces. One expression is obtained involving the potentials at the inner and outer surfaces of the membrane. A second expression involves the transmembrane potential and the normal component of membrane current.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Briller S. A., Geselowitz D. B., Arlinger S. D., Danielson G. K., Jaron D., Joyner C. R. The electrical interaction between artificial pacemakers and patients, with applications to electrocardiography. Am Heart J. 1966 May;71(5):656–665. doi: 10.1016/0002-8703(66)90316-4. [DOI] [PubMed] [Google Scholar]
  2. GELERNTER H. L., SWIHART J. C. A MATHEMATICAL-PHYSICAL MODEL OF THE GENESIS OF THE ELECTROCARDIOGRAM. Biophys J. 1964 Jul;4:285–301. doi: 10.1016/s0006-3495(64)86783-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. KAY C. F., SCHWAN H. P. Specific resistance of body tissues. Circ Res. 1956 Nov;4(6):664–670. doi: 10.1161/01.res.4.6.664. [DOI] [PubMed] [Google Scholar]
  4. PLONSEY R. VOLUME CONDUCTOR FIELDS OF ACTION CURRENTS. Biophys J. 1964 Jul;4:317–328. doi: 10.1016/s0006-3495(64)86785-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Plonsey R. An extension of the solid angle potential formulation for an active cell. Biophys J. 1965 Sep;5(5):663–667. doi: 10.1016/S0006-3495(65)86744-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. SCHWAN H. P., KAY C. F. Capacitive properties of body tissues. Circ Res. 1957 Jul;5(4):439–443. doi: 10.1161/01.res.5.4.439. [DOI] [PubMed] [Google Scholar]

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