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. 1967 Sep;7(5):555–565. doi: 10.1016/S0006-3495(67)86606-2

DNA Degradation in Escherichia coli 15 T-L- Induced by Fast Proton Bombardment

D C Huston, E C Pollard
PMCID: PMC1368081  PMID: 4860486

Abstract

DNA degradation and its temperature dependence as a function of linear energy transfer were studied in Excherichia coli using fast proton irradiation as the initiating agent. The data indicate that radiation-induced DNA degradation can proceed by two processes. The first, or fast component, begins immediately after irradiation with 60Co γ-rays or with fast protons at doses less than 1010 protons/cm2. The rate is high and involves a maximum of about 50% degradation. It is elicited more efficiently by protons of high linear energy transfer. The second, or slow component, results from higher doses of fast proton bombardment. There is a delay between irradiation and the initiation of this slower component, but 100% of the DNA complement is degraded. The data indicate that both processes are enzyme-mediated, the first probably by normal DNA-related activity and the second by DNAase activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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