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. 1990 Jul;30(1):115–118. doi: 10.1111/j.1365-2125.1990.tb03750.x

Effect of oral contraceptive steroids on the pharmacokinetics of phenprocoumon.

H Mönig 1, C Baese 1, H T Heidemann 1, E E Ohnhaus 1, H M Schulte 1
PMCID: PMC1368282  PMID: 2390422

Abstract

1. The effect of chronic administration of oral contraceptive steroids (OCS) on the pharmacokinetics of the oral anticoagulant phenprocoumon was investigated in seven healthy females. 2. Plasma concentrations of phenprocoumon and the urinary recovery of unchanged as well as conjugated drug were measured following a single oral dose of 0.22 mg kg-1. A group of seven non-smoking, drug-free women matched for age and body weight served as controls. 3. Administration of OCS was associated with a significant increase in the clearance of phenprocoumon from 1.6 +/- 0.7 to 2.0 +/- 0.7 ml min-1 kg-1 (P less than 0.05). The urinary recovery of phenprocoumon glucuronide was significantly higher in OCS users (21.0 +/- 16 vs 14.0 +/- 10 (% of dose); P less than 0.05). No difference in plasma protein binding of phenprocoumon was observed, being 99.2 +/- 0.07 in both groups. 4. The accelerated glucuronidation of phenprocoumon in OCS users suggests the need for careful monitoring of the anticoagulatory response in these subjects, especially when the OCS are withdrawn.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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