Abstract
The effects of single doses of clonidine hydrochloride (200 micrograms), yohimbine hydrochloride (22 mg), a combination of the two treatments, and placebo, on some autonomic functions were studied in healthy volunteers using a double-blind crossover design. Clonidine prolonged the recovery time of the light reflex, lowered systolic blood pressure and reduced subjectively rated alertness; these effects were reversed by yohimbine. Responsiveness of sweat glands to carbachol was not affected by the treatments.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bakes A., Bradshaw C. M., Szabadi E. Attenuation of the pupillary light reflex in anxious patients. Br J Clin Pharmacol. 1990 Sep;30(3):377–381. doi: 10.1111/j.1365-2125.1990.tb03787.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Banjar W., Longmore J., Bradshaw C. M., Szabadi E. The effect of diazepam on the responsiveness of human eccrine sweat glands to carbachol: influence of ambient temperature. Eur J Clin Pharmacol. 1987;31(6):661–665. doi: 10.1007/BF00541292. [DOI] [PubMed] [Google Scholar]
- Charney D. S., Heninger G. R. Noradrenergic function and the mechanism of action of antianxiety treatment. I. The effect of long-term alprazolam treatment. Arch Gen Psychiatry. 1985 May;42(5):458–467. doi: 10.1001/archpsyc.1985.01790280040004. [DOI] [PubMed] [Google Scholar]
- Kobinger Central alpha-adrenergic systems as targets for hypotensive drugs. Rev Physiol Biochem Pharmacol. 1978;81:39–100. doi: 10.1007/BFb0034091. [DOI] [PubMed] [Google Scholar]
- Kooner J. S., Peart W. S., Mathias C. J. The haemodynamic and hormonal responses after clonidine occur independently of sedation in essential hypertension. Br J Clin Pharmacol. 1989 Sep;28(3):249–255. doi: 10.1111/j.1365-2125.1989.tb05423.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Maple S., Bradshaw C. M., Szabadi E. Pharmacological responsiveness of sweat glands in anxious patients and healthy volunteers. Br J Psychiatry. 1982 Aug;141:154–161. doi: 10.1192/bjp.141.2.154. [DOI] [PubMed] [Google Scholar]