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. 1991 Jan;31(1):114–116. doi: 10.1111/j.1365-2125.1991.tb03869.x

The effects of enalapril and sulindac on the dermal response to substance P and neurokinin A.

R E Ferner 1, F Kamali 1, M D Rawlins 1
PMCID: PMC1368424  PMID: 1707646

Abstract

The effects of pretreatment with enalapril, and sulindac, on the weal response to intradermal injections of substance P and neurokinin A were assessed in a randomised, double-blind, placebo-controlled study. Weal responses to both substance P and neurokinin A depended significantly on dose. Neither enalapril nor sulindac, nor the combination of these agents influenced the responses to either tachykinin. These results do not suggest any role for substance P or neurokinin A in the clinical effects of angiotensin converting enzyme inhibitors.

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Selected References

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  1. Ferner R. E., Kamali F., Rawlins M. D. The effect of sulindac on dermal responses to bradykinin in normal subjects given an angiotensin converting enzyme inhibitor. Br J Clin Pharmacol. 1990 Mar;29(3):363–365. doi: 10.1111/j.1365-2125.1990.tb03649.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ferner R. E., Simpson J. M., Rawlins M. D. Effects of intradermal bradykinin after inhibition of angiotensin converting enzyme. Br Med J (Clin Res Ed) 1987 May 2;294(6580):1119–1120. doi: 10.1136/bmj.294.6580.1119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Ferner R. E., Wilson D., Paterson J. R., Wilkinson R., Rawlins M. D. The effects of intradermal bradykinin are potentiated by angiotensin converting enzyme inhibitors in hypertensive patients. Br J Clin Pharmacol. 1989 Mar;27(3):337–342. doi: 10.1111/j.1365-2125.1989.tb05374.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Foreman J. C., Jordan C. C., Oehme P., Renner H. Structure-activity relationships for some substance P-related peptides that cause wheal and flare reactions in human skin. J Physiol. 1983 Feb;335:449–465. doi: 10.1113/jphysiol.1983.sp014543. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fuller R. W., Conradson T. B., Dixon C. M., Crossman D. C., Barnes P. J. Sensory neuropeptide effects in human skin. Br J Pharmacol. 1987 Dec;92(4):781–788. doi: 10.1111/j.1476-5381.1987.tb11381.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fuller R. W., Warren J. B., McCusker M., Dollery C. T. Effect of enalapril on the skin response to bradykinin in man. Br J Clin Pharmacol. 1987 Jan;23(1):88–90. doi: 10.1111/j.1365-2125.1987.tb03014.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lindgren B. R., Anderson C. D., Andersson R. G. Potentiation of inflammatory reactions in guinea-pig skin by an angiotensin converting enzyme inhibitor (MK 422). Eur J Pharmacol. 1987 Mar 31;135(3):383–387. doi: 10.1016/0014-2999(87)90688-1. [DOI] [PubMed] [Google Scholar]
  8. Nicholls M. G., Gilchrist N. L. Sulindac and cough induced by converting enzyme inhibitors. Lancet. 1987 Apr 11;1(8537):872–872. doi: 10.1016/s0140-6736(87)91663-1. [DOI] [PubMed] [Google Scholar]
  9. Swartz S. L., Williams G. H., Hollenberg N. K., Moore T. J., Dluhy R. G. Converting enzyme inhibition in essential hypertension: the hypotensive response does not reflect only reduced angiotensin II formation. Hypertension. 1979 Mar-Apr;1(2):106–111. doi: 10.1161/01.hyp.1.2.106. [DOI] [PubMed] [Google Scholar]
  10. Wilkin J. K., Hammond J. J., Kirkendall W. M. The captopril-induced eruption. A possible mechanism: cutaneous kinin potentiation. Arch Dermatol. 1980 Aug;116(8):902–905. [PubMed] [Google Scholar]
  11. Wood S. M., Mann R. D., Rawlins M. D. Angio-oedema and urticaria associated with angiotensin converting enzyme inhibitors. Br Med J (Clin Res Ed) 1987 Jan 10;294(6564):91–92. doi: 10.1136/bmj.294.6564.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Yang H. Y., Erdös E. G., Levin Y. Characterization of a dipeptide hydrolase (kininase II: angiotensin I converting enzyme). J Pharmacol Exp Ther. 1971 Apr;177(1):291–300. [PubMed] [Google Scholar]
  13. Yokosawa H., Endo S., Ohgaki Y., Maeyama J., Ishii S. Hydrolysis of substance P and its analogs by angiotensin-converting enzyme from rat lung. Characterization of endopeptidase activity of the enzyme. J Biochem. 1985 Nov;98(5):1293–1299. doi: 10.1093/oxfordjournals.jbchem.a135396. [DOI] [PubMed] [Google Scholar]

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