Skip to main content
PMC home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1991 May;31(5):501–514. doi: 10.1111/j.1365-2125.1991.tb05571.x

The 1990 Lilly Prize Lecture. A way of looking at agonism and antagonism: lessons from salbutamol, salmeterol and other beta-adrenoceptor agonists.

D Jack 1
PMCID: PMC1368467  PMID: 1679656

Full text

PDF
501

Images in this article

509Figure 8
on p.509
509Figure 9(a)
on p.509
509Figure 9(b)
on p.509
509Figure 10
on p.509

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bilezikian J. P., Dornfeld A. M., Gammon D. E. Structure-binding-activity analysis of beta-adrenergic amines--I. Binding to the beta receptor and activation of adenylate cyclase. Biochem Pharmacol. 1978 May 15;27(10):1445–1454. doi: 10.1016/0006-2952(78)90100-4. [DOI] [PubMed] [Google Scholar]
  2. Birnbaumer L., Yatani A., VanDongen A. M., Graf R., Codina J., Okabe K., Mattera R., Brown A. M. G protein coupling of receptors to ionic channels and other effector systems. Br J Clin Pharmacol. 1990;30 (Suppl 1):13S–22S. doi: 10.1111/j.1365-2125.1990.tb05463.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brittain R. T., Dean C. M., Jack D. Sympathomimetic bronchodilator drugs. Pharmacol Ther B. 1976;2(3):423–462. doi: 10.1016/0306-039x(76)90001-5. [DOI] [PubMed] [Google Scholar]
  4. Brittain R. T., Jack D., Ritchie A. C. Recent beta-adrenoreceptor stimulants. Adv Drug Res. 1970;5:197–253. [PubMed] [Google Scholar]
  5. Coleman R. A., Farmer J. B. The inducement of tone and its inhibition in isolated tracheal muscle. J Pharm Pharmacol. 1971 Mar;23(3):220–222. doi: 10.1111/j.2042-7158.1971.tb08648.x. [DOI] [PubMed] [Google Scholar]
  6. Collin D. T., Hartley D., Jack D., Lunts L. H., Press J. C., Ritchie A. C., Toon P. Saligenin analogs of sympathomimetic catecholamines. J Med Chem. 1970 Jul;13(4):674–680. doi: 10.1021/jm00298a022. [DOI] [PubMed] [Google Scholar]
  7. Donbrow M., Hoffman A., Benita S. Variation of population release kinetics in polydisperse multiparticulate systems (microcapsules, microspheres, droplets, cells) with heterogeneity of one, two or three parameters in the population of individuals. J Pharm Pharmacol. 1988 Feb;40(2):93–96. doi: 10.1111/j.2042-7158.1988.tb05188.x. [DOI] [PubMed] [Google Scholar]
  8. GADDUM J. H. The technique of superfusion. Br J Pharmacol Chemother. 1953 Sep;8(3):321–326. doi: 10.1111/j.1476-5381.1953.tb00801.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gilman A. G. G proteins: transducers of receptor-generated signals. Annu Rev Biochem. 1987;56:615–649. doi: 10.1146/annurev.bi.56.070187.003151. [DOI] [PubMed] [Google Scholar]
  10. Harvey J. E., Tattersfield A. E. Airway response to salbutamol: effect of regular salbutamol inhalations in normal, atopic, and asthmatic subjects. Thorax. 1982 Apr;37(4):280–287. doi: 10.1136/thx.37.4.280. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Henderson R., Unwin P. N. Three-dimensional model of purple membrane obtained by electron microscopy. Nature. 1975 Sep 4;257(5521):28–32. doi: 10.1038/257028a0. [DOI] [PubMed] [Google Scholar]
  12. Hjemdahl P., Larsson K., Johansson M. C., Zetterlund A., Eklund A. Beta-adrenoceptors in human alveolar macrophages isolated by elutriation. Br J Clin Pharmacol. 1990 Nov;30(5):673–682. doi: 10.1111/j.1365-2125.1990.tb03835.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Jack D. Safety by design. Drug Saf. 1990;5 (Suppl 1):4–23. doi: 10.2165/00002018-199000051-00004. [DOI] [PubMed] [Google Scholar]
  14. Johnson M. The pharmacology of salmeterol. Lung. 1990;168 (Suppl):115–119. doi: 10.1007/BF02718123. [DOI] [PubMed] [Google Scholar]
  15. Johnson S. M., Fleming W. W. Mechanisms of cellular adaptive sensitivity changes: applications to opioid tolerance and dependence. Pharmacol Rev. 1989 Dec;41(4):435–488. [PubMed] [Google Scholar]
  16. Kenakin T. P. Challenges for receptor theory as a tool for drug and drug receptor classification. Trends Pharmacol Sci. 1989 Jan;10(1):18–22. doi: 10.1016/0165-6147(89)90102-8. [DOI] [PubMed] [Google Scholar]
  17. Lands A. M., Arnold A., McAuliff J. P., Luduena F. P., Brown T. G., Jr Differentiation of receptor systems activated by sympathomimetic amines. Nature. 1967 May 6;214(5088):597–598. doi: 10.1038/214597a0. [DOI] [PubMed] [Google Scholar]
  18. Lands A. M., Luduena F. P., Buzzo H. J. Differentiation of receptors responsive to isoproterenol. Life Sci. 1967 Nov 1;6(21):2241–2249. doi: 10.1016/0024-3205(67)90031-8. [DOI] [PubMed] [Google Scholar]
  19. Minneman K. P., Hegstrand L. R., Molinoff P. B. The pharmacological specificity of beta-1 and beta-2 adrenergic receptors in rat heart and lung in vitro. Mol Pharmacol. 1979 Jul;16(1):21–33. [PubMed] [Google Scholar]
  20. Robison G. A., Butcher R. W., Sutherland E. W. Adenyl cyclase as an adrenergic receptor. Ann N Y Acad Sci. 1967 Feb 10;139(3):703–723. doi: 10.1111/j.1749-6632.1967.tb41239.x. [DOI] [PubMed] [Google Scholar]
  21. STEPHENSON R. P. A modification of receptor theory. Br J Pharmacol Chemother. 1956 Dec;11(4):379–393. doi: 10.1111/j.1476-5381.1956.tb00006.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Scriabine A., Moore P. F., Iorio L. C., Goldman I. M., McShane W. K., Booher K. D. Quinterenol, a new beta adrenergic stimulant. J Pharmacol Exp Ther. 1968 Jul;162(1):60–69. [PubMed] [Google Scholar]
  23. Sears M. R., Taylor D. R., Print C. G., Lake D. C., Li Q. Q., Flannery E. M., Yates D. M., Lucas M. K., Herbison G. P. Regular inhaled beta-agonist treatment in bronchial asthma. Lancet. 1990 Dec 8;336(8728):1391–1396. doi: 10.1016/0140-6736(90)93098-a. [DOI] [PubMed] [Google Scholar]
  24. Strader C. D., Sigal I. S., Dixon R. A. Genetic approaches to the determination of structure-function relationships of G protein-coupled receptors. Trends Pharmacol Sci. 1989 Dec;Suppl:26–30. [PubMed] [Google Scholar]
  25. Twentyman O. P., Finnerty J. P., Harris A., Palmer J., Holgate S. T. Protection against allergen-induced asthma by salmeterol. Lancet. 1990 Dec 1;336(8727):1338–1342. doi: 10.1016/0140-6736(90)92894-n. [DOI] [PubMed] [Google Scholar]
  26. Ullman A., Svedmyr N. Salmeterol, a new long acting inhaled beta 2 adrenoceptor agonist: comparison with salbutamol in adult asthmatic patients. Thorax. 1988 Sep;43(9):674–678. doi: 10.1136/thx.43.9.674. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES