Abstract
alpha 1-acid glycoprotein (AAG) concentration and the binding of both lignocaine and warfarin were compared in 15 healthy Chinese and age and sex matched Irish (Caucasian) subjects. Both the extent of lignocaine binding and AAG concentrations were significantly (P less than 0.05) lower in Chinese subjects. No difference was shown in warfarin binding. These results suggest that the binding of basic drugs may be significantly less in Chinese than Caucasians, and lower concentrations of the binding protein AAG are a major determinant of this difference.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brørs O., Jacobsen S. pH lability in serum during equilibrium dialysis. Br J Clin Pharmacol. 1985 Jul;20(1):85–88. doi: 10.1111/j.1365-2125.1985.tb02803.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clark D. W. Genetically determined variability in acetylation and oxidation. Therapeutic implications. Drugs. 1985 Apr;29(4):342–375. doi: 10.2165/00003495-198529040-00003. [DOI] [PubMed] [Google Scholar]
- Ghoneim M. M., Korttila K., Chiang C. K., Jacobs L., Schoenwald R. D., Mewaldt S. P., Kayaba K. O. Diazepam effects and kinetics in Caucasians and Orientals. Clin Pharmacol Ther. 1981 Jun;29(6):749–756. doi: 10.1038/clpt.1981.106. [DOI] [PubMed] [Google Scholar]
- Routledge P. A. The plasma protein binding of basic drugs. Br J Clin Pharmacol. 1986 Nov;22(5):499–506. doi: 10.1111/j.1365-2125.1986.tb02927.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Spector R., Choudhury A. K., Chiang C. K., Goldberg M. J., Ghoneim M. M. Diphenhydramine in Orientals and Caucasians. Clin Pharmacol Ther. 1980 Aug;28(2):229–234. doi: 10.1038/clpt.1980.155. [DOI] [PubMed] [Google Scholar]
- Wolff P. H. Ethnic differences in alcohol sensitivity. Science. 1972 Jan 28;175(4020):449–450. doi: 10.1126/science.175.4020.449. [DOI] [PubMed] [Google Scholar]
- Zhou H. H., Adedoyin A., Wilkinson G. R. Differences in plasma binding of drugs between Caucasians and Chinese subjects. Clin Pharmacol Ther. 1990 Jul;48(1):10–17. doi: 10.1038/clpt.1990.111. [DOI] [PubMed] [Google Scholar]
- Zhou H. H., Koshakji R. P., Silberstein D. J., Wilkinson G. R., Wood A. J. Altered sensitivity to and clearance of propranolol in men of Chinese descent as compared with American whites. N Engl J Med. 1989 Mar 2;320(9):565–570. doi: 10.1056/NEJM198903023200905. [DOI] [PubMed] [Google Scholar]