Abstract
The penetration of minocycline into different lung tissues and bronchial mucus was studied in 17 patients undergoing pulmonary surgery for cancer. The patients received oral minocycline 100 mg at night for 3 days preceding surgery. Minocycline concentrations were measured in plasma samples collected before the operation and in tissues and mucus taken from in and around the part of the lung that was surgically removed. Mean tissue or mucus concentration to plasma concentration ratios were 3.78 +/- 1.10 for lung parenchyma, 4.04 +/- 1.31 for bronchial walls, 3.37 +/- 1.00 for pulmonary arterial walls, 1.99 +/- 1.80 for intraluminal mucus collected from bronchi located in healthy tissue proximal to the tumour, 5.16 +/- 3.26 for intraluminal mucus collected in a bronchus distal to the tumour, and 3.06 +/- 1.99 for catheter-collected mucus from the trachea and principal bronchi. These results indicate that minocycline is found in high concentration in all types of lung tissue and mucus in man.
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Selected References
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- Brogan T. D., Neale L., Ryley H. C., Davies B. H., Charles J. The secretion of minocycline in sputum during therapy of bronchopulmonary infection in chronic chest diseases. J Antimicrob Chemother. 1977 May;3(3):247–251. doi: 10.1093/jac/3.3.247. [DOI] [PubMed] [Google Scholar]
- Clauzel A. M., Bonnet D., Allegrini J., Simeon de Buochberg M. Concentrations de minocycline dans les sécrétions bronchiques. Nouv Presse Med. 1978 Dec 23;7(46):4236–4236. [PubMed] [Google Scholar]
- Lambert H. P. Clinical significance of tissue penetration of antibiotics in the respiratory tract. Scand J Infect Dis Suppl. 1978;(14):262–266. [PubMed] [Google Scholar]
- Macdonald H., Kelly R. G., Allen E. S., Noble J. F., Kanegis L. A. Pharmacokinetic studies on minocycline in man. Clin Pharmacol Ther. 1973 Sep-Oct;14(5):852–861. doi: 10.1002/cpt1973145852. [DOI] [PubMed] [Google Scholar]
- Maesen F. P., Davies B. I., van den Bergh J. J. Doxycycline and minocycline in the treatment of respiratory infections: a double-blind comparative clinical, microbiological and pharmacokinetic study. J Antimicrob Chemother. 1989 Jan;23(1):123–129. doi: 10.1093/jac/23.1.123. [DOI] [PubMed] [Google Scholar]
- Naline E., Roudière J. P., Cordonnier P., Varoquaux O., Brion N., Toty L., Bakdach H., Pays M., Advenier C. Diffusion de la minocycline dans le tissu pulmonaire. Therapie. 1991 Jan-Feb;46(1):9–12. [PubMed] [Google Scholar]
- Saivin S., Houin G. Clinical pharmacokinetics of doxycycline and minocycline. Clin Pharmacokinet. 1988 Dec;15(6):355–366. doi: 10.2165/00003088-198815060-00001. [DOI] [PubMed] [Google Scholar]