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. 1991 Dec;32(6):751–754.

Excretion of indomethacin in breast milk.

T H Lebedevs 1, R E Wojnar-Horton 1, P Yapp 1, M J Roberts 1, L J Dusci 1, L P Hackett 1, K F Ilett 1
PMCID: PMC1368557  PMID: 1768569

Abstract

1. The excretion of indomethacin into breast milk and subsequent exposure of infants was studied in 16 women and seven of their infants. The median milk:plasma ratio in seven patients where there were measurable drug concentrations in both milk and plasma was 0.37. 2. Total infant dose, assuming a daily milk intake of 150 ml kg-1 and 100% absorption, ranged from 0.07% to 0.98% (median = 0.18%) of the weight adjusted maternal dose. 3. Plasma samples were obtained in seven infants. In six of these, indomethacin concentrations were below the sensitivity of the assay (less than 20 micrograms l-1), while one infant had a plasma indomethacin concentration of 47 micrograms l-1. 4. No adverse effects due to indomethacin were reported in the infants.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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