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. 1991 Dec;32(6):751–754.

Excretion of indomethacin in breast milk.

T H Lebedevs 1, R E Wojnar-Horton 1, P Yapp 1, M J Roberts 1, L J Dusci 1, L P Hackett 1, K F Ilett 1
PMCID: PMC1368557  PMID: 1768569

Abstract

1. The excretion of indomethacin into breast milk and subsequent exposure of infants was studied in 16 women and seven of their infants. The median milk:plasma ratio in seven patients where there were measurable drug concentrations in both milk and plasma was 0.37. 2. Total infant dose, assuming a daily milk intake of 150 ml kg-1 and 100% absorption, ranged from 0.07% to 0.98% (median = 0.18%) of the weight adjusted maternal dose. 3. Plasma samples were obtained in seven infants. In six of these, indomethacin concentrations were below the sensitivity of the assay (less than 20 micrograms l-1), while one infant had a plasma indomethacin concentration of 47 micrograms l-1. 4. No adverse effects due to indomethacin were reported in the infants.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alván G., Orme M., Bertilsson L., Ekstrand R., Palmér L. Pharmacokinetics of indomethacin. Clin Pharmacol Ther. 1975 Sep;18(3):364–373. doi: 10.1002/cpt1975183364. [DOI] [PubMed] [Google Scholar]
  2. Eeg-Olofsson O., Malmros I., Elwin C. E., Steen B. Convulsions in a breast-fed infant after maternal indomethacin. Lancet. 1978 Jul 22;2(8082):215–215. doi: 10.1016/s0140-6736(78)91962-1. [DOI] [PubMed] [Google Scholar]
  3. Engel C., Lund B., Kristensen S. S., Axel C., Nielsen J. B. Indomethacin as an analgesic after hysterectomy. Acta Anaesthesiol Scand. 1989 Aug;33(6):498–501. doi: 10.1111/j.1399-6576.1989.tb02953.x. [DOI] [PubMed] [Google Scholar]
  4. Helleberg L. Clinical Pharmacokinetics of indomethacin. Clin Pharmacokinet. 1981 Jul-Aug;6(4):245–258. doi: 10.2165/00003088-198106040-00001. [DOI] [PubMed] [Google Scholar]
  5. Macheras P. E., Koupparis M. A., Antimisiaris S. G. Drug binding and solubility in milk. Pharm Res. 1990 May;7(5):537–541. doi: 10.1023/a:1015881103340. [DOI] [PubMed] [Google Scholar]
  6. Needs C. J., Brooks P. M. Antirheumatic medication during lactation. Br J Rheumatol. 1985 Aug;24(3):291–297. doi: 10.1093/rheumatology/24.3.291. [DOI] [PubMed] [Google Scholar]
  7. Olkkola K. T., Maunuksela E. L., Korpela R. Pharmacokinetics of postoperative intravenous indomethacin in children. Pharmacol Toxicol. 1989 Aug;65(2):157–160. doi: 10.1111/j.1600-0773.1989.tb01147.x. [DOI] [PubMed] [Google Scholar]
  8. Thind P., Sigsgaard T. The analgesic effect of indomethacin in the early post-operative period following abdominal surgery. A double-blind controlled study. Acta Chir Scand. 1988 Jan;154(1):9–12. [PubMed] [Google Scholar]
  9. Vert P., Bianchetti G., Marchal F., Monin P., Morselli P. L. Effectiveness and pharmacokinetics of indomethacin in premature newborns with patent ductus arteriosus. Eur J Clin Pharmacol. 1980 Jul;18(1):83–88. doi: 10.1007/BF00561483. [DOI] [PubMed] [Google Scholar]
  10. Walters M. Tolerance of intravenous indomethacin treatment for premature infants with patent ductus arteriosus. BMJ. 1988 Sep 24;297(6651):773–774. doi: 10.1136/bmj.297.6651.773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Wilson J. T., Brown R. D., Cherek D. R., Dailey J. W., Hilman B., Jobe P. C., Manno B. R., Manno J. E., Redetzki H. M., Stewart J. J. Drug excretion in human breast milk: principles, pharmacokinetics and projected consequences. Clin Pharmacokinet. 1980 Jan-Feb;5(1):1–66. doi: 10.2165/00003088-198005010-00001. [DOI] [PubMed] [Google Scholar]

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