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Drug Design, Development and Therapy logoLink to Drug Design, Development and Therapy
. 2026 Oct 21;20:663559. doi: 10.2147/DDDT.S663559

PACE4 Regulates Apoptosis in Human Prostate Cancer Cells via Endoplasmic Reticulum Stress and Mitochondrial Signaling Pathways [Retraction]

PMCID: PMC13696159  PMID: 42935703

Yao Z, Sun B, Hong Q, et al. Drug Des Devel Ther. 2015;9:5911—5923. https://doi.org/10.2147/DDDT.S86881

We, the Editors and Publisher of the journal Drug Design, Development and Therapy, have retracted the published article.

After publication, concerns have been raised by a third party in 2025 about the integrity of the data in Figure 3 of the article.

Further investigation conducted by the Journal and Publisher confirmed the following:

  • Unusual similarities present in the image panels representative of different samples and conditions in Figure 3.

  • Unexpected overlaps between Western blots in Figure 7 with Western blots in the following article:

    Zhao X, Hua Y, Chen H, Yang H, Zhang T, Huang G, Zhou Y. Aldehyde dehydrogenase-2 protects against myocardial infarction-related cardiac fibrosis through modulation of the Wnt/β-catenin signaling pathway. Therapeutics and Clinical Risk Management. 2015;11:1371–1381. https://doi.org/10.2147/TCRM.S88297

When approached for an explanation, the authors did not respond to the queries raised by the Journal and Publisher.

As verifying the validity of published work is core to the integrity of the scholarly record, we are therefore retracting the article. The corresponding author listed in this publication has been informed.

We have been informed in our decision-making by our editorial policies and the COPE guidelines.

The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’.


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