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. 1999 Dec;5(12):1597–1604. doi: 10.1017/s1355838299991288

Human Nop5/Nop58 is a component common to the box C/D small nucleolar ribonucleoproteins.

S K Lyman 1, L Gerace 1, S J Baserga 1
PMCID: PMC1369881  PMID: 10606270

Abstract

We have identified an apparent human homolog of the yeast Nop5/Nop58 protein. hNop5/Nop58 codes for a protein of predicted molecular weight 59.6 kDa and is 46.8% identical to Saccharomyces cerevisiae Nop5/Nop58. Immunofluorescent staining with antibodies against hNop5/Nop58 indicate that it is localized primarily to the nucleolus, and coimmunoprecipitation from nuclear extracts demonstrates that hNop5/Nop58 interacts with the box C/D family of snoRNAs. Thus, hNop5/Nop58 is a common component of the box C/D snoRNPs, and joins fibrillarin as the second such component identified and characterized in metazoans.

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Selected References

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