Abstract
Background
Artificial intelligence (AI) is increasingly used in breast cancer screening, but its performance may be influenced by image quality, potentially leading to inappropriate recalls. Within a project funded by the Italian Ministry of Health, this study evaluated the association between AI-generated scores (Lunit INSIGHT MMG) and technical errors in screening mammography, and their impact on recall rates.
Methods
A retrospective observational study was conducted on 5,000 consecutive screening mammograms. Examinations were independently read by two radiologists, and women were recalled if at least one reader indicated further assessment. AI scores were extracted for recalled cases and stratified into three groups (1–30, 30–60, >60). Images were independently reviewed by two expert breast radiologists to identify technical errors using standardized criteria (inadequate positioning, incomplete visualization, insufficient compression, artifacts). Associations were assessed using chi-square test and logistic regression.
Results
The overall recall rate was 14.3% (714/5,000). Technical errors were identified in 150/714 exams (21.0%). Error frequency was significantly higher in the 1–30 score group (39.9%) compared with 30–60 (18.2%) and >60 (6.5%) (p < 0.001). The most frequent errors were inadequate positioning (44.7%) and incomplete visualization (30.0%), mainly associated with lower scores. Logistic regression showed a significant inverse association between AI score and technical error (OR 0.72 per 10-point increase; 95% CI 0.66–0.78). After repeat imaging without technical errors, AI flagging resolved in 97.3% of cases.
Conclusions
Image quality significantly influences AI output in mammography screening. Optimizing acquisition techniques can substantially reduce avoidable recalls and improve the efficiency of population-based screening programmes.
Key messages
• Improving image quality can significantly reduce unnecessary recalls in AI-supported screening programmes.
• Integrating AI with robust quality control can optimise resource use and screening efficiency.