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. 2000 Apr;6(4):485–498. doi: 10.1017/s1355838200000224

The scene of a frozen accident.

A D Ellington 1, M Khrapov 1, C A Shaw 1
PMCID: PMC1369930  PMID: 10786840

Abstract

It has been suggested that in vitro selection experiments can provide information not only on what might have occurred during the evolution of the RNA world, but can in fact yield insights into particular features of the RNA world. In particular, it has been suggested that the sequences of anti-amino acid aptamers can provide clues to the origin of the genetic code, and that there is a statistically significant association between motifs found in aptamers and codons. We argue that the suggested connections between modern motifs and ancient sequences are logically tenuous, and show that there is no statistically meaningful association between motifs found in aptamers and codons.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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