Abstract
Background
Despite the scientific advances in omics technologies, the translation of precision approaches into population-level prevention strategies remains limited. The EU-funded project “A PeRsOnalised Prevention roadmap for the future HEalThcare in Europe” (PROPHET) promotes a comprehensive vision of personalised prevention (PP) that integrates biomedical, behavioural and social determinants of health.
Methods
Based on literature mapping, consortium input and large stakeholder engagement, the SRIA identified key challenges for the implementation of PP, while the accompanying Roadmap translated these challenges into concrete actions by outlining goals, priority actions, timelines, expected outcomes and output indicators, responsible entities, funding sources, and synergies with other EU initiatives.
Results
Ten challenges for implementing PP have been identified: Scope of health promotion and prevention; Continuous evidence synthesis for PP; Implementation of the PROPHET framework; Data collection, integration and infrastructure; Community engagement and trust; Involvement of health professionals and policy makers; Regulatory frameworks and collaboration with the private sector; Access, equity and coverage; Ethical, legal and social issues (ELSI); Behaviour change. Across the ten challenges, the roadmap identifies a comprehensive set of 56 goals and 66 actions aimed at strengthening evidence generation, interoperability, real-world implementation and capacity building. The anticipated implementation timeline spans the next five years, with the aim of generating long-term impact on European health systems. For most of the actions, the principal entities responsible for supporting implementation include the European Commission (DG SANTE, DG RTD), National Ministries of Health and related agencies, and the research community.
Conclusions
The SRIA and Roadmap highlight both the opportunities and the potential barriers that may emerge during PP implementation.
Key messages
• The SRIA outlines the key areas that must be addressed in order to fully realise the potential of PP within European health systems.
• Implementation of PP requires coordinated investment and collaboration among European institutions, national authorities and the research community.