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. 2002 Jul;8(7):873–877. doi: 10.1017/s135583820202602x

GU receptors of double helices mediate tRNA movement in the ribosome.

Matthieu G Gagnon 1, Sergey V Steinberg 1
PMCID: PMC1370304  PMID: 12166642

Abstract

A new RNA structural motif consisting of two double helices closely packed via minor grooves is found in many places in the ribosome structure. The packing requires that a GU base pair in one helix be packed against a Watson-Crick pair in the other helix. Two such motifs mediate the interaction of the P- and E-tRNA with the large ribosomal subunit. Analysis of the particular positions of these two motifs in view of the available data on occupancy of tRNA-binding sites and structural changes in the ribosome during the elongation cycle suggests a distinct role for each motif in tRNA translocation.

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Selected References

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