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. 1990 Mar;40(332):114–116.

A review of the factors associated with patient compliance and the taking of prescribed medicines.

S Griffith 1
PMCID: PMC1371078  PMID: 2112014

Abstract

Patient non-compliance is an ever present and complex issue, the importance of which is likely to increase in successive years as the population ages. Non-compliant behaviour is not only costly in terms of time, money and resources, but can also be detrimental to the doctor-patient relationship. Assessment of the prevalence and nature of non-compliance is difficult, but several determinant factors have been found to be associated with it. The aim of this review is to consider these factors and so increase the doctor's awareness of this problem.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baekeland F., Lundwall L. Dropping out of treatment: a critical review. Psychol Bull. 1975 Sep;82(5):738–783. doi: 10.1037/h0077132. [DOI] [PubMed] [Google Scholar]
  2. Becker M. H., Maiman L. A. Sociobehavioral determinants of compliance with health and medical care recommendations. Med Care. 1975 Jan;13(1):10–24. doi: 10.1097/00005650-197501000-00002. [DOI] [PubMed] [Google Scholar]
  3. Blackwell B. Drug therapy: patient compliance. N Engl J Med. 1973 Aug 2;289(5):249–252. doi: 10.1056/NEJM197308022890506. [DOI] [PubMed] [Google Scholar]
  4. Carey R. M., Reid R. A., Ayers C. R., Lynch S. S., McLain W. L., 3rd, Vaughan E. D., Jr The Charlottesville Blood-Pressure Survey. Value of repeated blood-pressure measurements. JAMA. 1976 Aug 16;236(7):847–851. [PubMed] [Google Scholar]
  5. Chapman S. F. Psychotropic drug use in the elderly. Public ignorance or indifference? Med J Aust. 1976 Jul 10;2(2):62–64. [PubMed] [Google Scholar]
  6. Charney E., Bynum R., Eldredge D., Frank D., MacWhinney J. B., McNabb N., Scheiner A., Sumpter E. A., Iker H. How well do patients take oral penicillin? A collaborative study in private practice. Pediatrics. 1967 Aug;40(2):188–195. [PubMed] [Google Scholar]
  7. DAVIS M. S., EICHHORN R. L. COMPLIANCE WITH MEDICAL REGIMENS: A PANEL STUDY. J Health Hum Behav. 1963;4(4):240–249. [PubMed] [Google Scholar]
  8. Davis M. S. Variations in patients' compliance with doctors' advice: an empirical analysis of patterns o communication. Am J Public Health Nations Health. 1968 Feb;58(2):274–288. doi: 10.2105/ajph.58.2.274. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Evans L., Spelman M. The problem of non-compliance with drug therapy. Drugs. 1983 Jan;25(1):63–76. doi: 10.2165/00003495-198325010-00004. [DOI] [PubMed] [Google Scholar]
  10. Finnerty F. A., Jr, Shaw L. W., Himmelsbach C. K. Hypertension in the inner city. II. Detection and follow-up. Circulation. 1973 Jan;47(1):76–78. doi: 10.1161/01.cir.47.1.76. [DOI] [PubMed] [Google Scholar]
  11. Francis V., Korsch B. M., Morris M. J. Gaps in doctor-patient communication. Patients' response to medical advice. N Engl J Med. 1969 Mar 6;280(10):535–540. doi: 10.1056/NEJM196903062801004. [DOI] [PubMed] [Google Scholar]
  12. Geyskes G. G., Misage J. R., Bron K., Haas J. E., Berg G., Shapiro A. P. Malignant hypertension following renal artery branch obstruction. JAMA. 1972 Oct;222(4):457–459. [PubMed] [Google Scholar]
  13. Gilbert J. R., Evans C. E., Haynes R. B., Tugwell P. Predicting compliance with a regimen of digoxin therapy in family practice. Can Med Assoc J. 1980 Jul 19;123(2):119–122. [PMC free article] [PubMed] [Google Scholar]
  14. Gryfe C. I., Gryfe B. M. Drug therapy of the aged: the problem of compliance and the roles of physicians and pharmacists. J Am Geriatr Soc. 1984 Apr;32(4):301–307. doi: 10.1111/j.1532-5415.1984.tb02026.x. [DOI] [PubMed] [Google Scholar]
  15. Hare E. H., Willcox D. R. Do psychiatric in-patients take their pills? Br J Psychiatry. 1967 Dec;113(505):1435–1439. doi: 10.1192/bjp.113.505.1435. [DOI] [PubMed] [Google Scholar]
  16. Hulka B. S., Kupper L. L., Cassel J. C., Efird R. L. Medication use and misuse: physician-patient discrepancies. J Chronic Dis. 1975 Jan;28(1):7–21. doi: 10.1016/0021-9681(75)90045-4. [DOI] [PubMed] [Google Scholar]
  17. Jackson H., Cooper J., Mellinger W. J., Olsen A. R. Streptococcal pharyngitis in rural practice. Rational medical management. JAMA. 1966 Aug 8;197(6):385–388. [PubMed] [Google Scholar]
  18. LUNTZ G. R., AUSTIN R. New stick test for P.A.S. in urine. Report on use of "phenistix" and problems of long-term chemotherapy for tuberculosis. Br Med J. 1960 Jun 4;1(5187):1679–1684. doi: 10.1136/bmj.1.5187.1679. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Ley P. Memory for medical information. Br J Soc Clin Psychol. 1979 Jun;18(2):245–255. doi: 10.1111/j.2044-8260.1979.tb00333.x. [DOI] [PubMed] [Google Scholar]
  20. MOHLER D. N., WALLIN D. G., DREYFUS E. G. Studies in the home treatment of streptococcal disease. I. Failure of patients to take penicillin by mouth as prescribed. N Engl J Med. 1955 Jun 30;252(26):1116–1118. doi: 10.1056/NEJM195506302522604. [DOI] [PubMed] [Google Scholar]
  21. Malahy B. The effect of instruction and labeling on the number of medication errors made by patients at home. Am J Hosp Pharm. 1966 Jun;23(6):283–292. [PubMed] [Google Scholar]
  22. Meyers A., Dolan T. F., Jr, Mueller D. Compliance and self-medication in cystic fibrosis. Am J Dis Child. 1975 Sep;129(9):1011–1013. doi: 10.1001/archpedi.1975.02120460005002. [DOI] [PubMed] [Google Scholar]
  23. Mushlin A. I., Appel F. A. Diagnosing potential noncompliance. Physicians' ability in a behavioral dimension of medical care. Arch Intern Med. 1977 Mar;137(3):318–321. doi: 10.1001/archinte.137.3.318. [DOI] [PubMed] [Google Scholar]
  24. Norell S. E. Accuracy of patient interviews and estimates by clinical staff in determining medication compliance. Soc Sci Med E. 1981 Feb;15(1):57–61. doi: 10.1016/0271-5384(81)90063-6. [DOI] [PubMed] [Google Scholar]
  25. Porter A. M. Drug defaulting in a general practice. Br Med J. 1969 Jan 25;1(5638):218–222. doi: 10.1136/bmj.1.5638.218. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Rickels K., Briscoe E. Assessment of dosage deviation in outpatient drug research. J Clin Pharmacol J New Drugs. 1970 May-Jun;10(3):153–160. [PubMed] [Google Scholar]
  27. Robbins J. A. Patient compliance. Prim Care. 1980 Dec;7(4):703–711. [PubMed] [Google Scholar]
  28. Rosenberg C. M. Drug maintenance in the outpatient treatment of chronic alcoholism. Arch Gen Psychiatry. 1974 Mar;30(3):373–377. doi: 10.1001/archpsyc.1974.01760090079013. [DOI] [PubMed] [Google Scholar]
  29. Rosenstock I. M. Enhancing patient compliance with health recommendations. J Pediatr Health Care. 1988 Mar-Apr;2(2):67–72. doi: 10.1016/0891-5245(88)90169-1. [DOI] [PubMed] [Google Scholar]
  30. Ross D. J., Guggenheim F. G. Compliance and the health belief model: a challenge for the liaison psychiatrist. Gen Hosp Psychiatry. 1983 Apr;5(1):31–35. doi: 10.1016/0163-8343(83)90041-5. [DOI] [PubMed] [Google Scholar]
  31. Roth H. P., Caron H. S. Accuracy of doctors' estimates and patients' statements on adherence to a drug regimen. Clin Pharmacol Ther. 1978 Mar;23(3):361–370. doi: 10.1002/cpt1978233361. [DOI] [PubMed] [Google Scholar]
  32. Roth H. P., Caron H. S., Hsi B. P. Measuring intake of a prescribed medication. A bottle count and a tracer technique compared. Clin Pharmacol Ther. 1970 Mar-Apr;11(2):228–237. doi: 10.1002/cpt1970112228. [DOI] [PubMed] [Google Scholar]
  33. Stimson G. V. Obeying doctor's orders: a view from the other side. Soc Sci Med. 1974 Feb;8(2):97–104. doi: 10.1016/0037-7856(74)90039-0. [DOI] [PubMed] [Google Scholar]
  34. Zola I. K. Thoughts on improving compliance in elderly arthritics. Geriatrics. 1986 Aug;41(8):81-2, 85. [PubMed] [Google Scholar]

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