Abstract
Previous studies have provided conflicting results on the presence of hepatitis C virus-RNA in saliva. In this study, 23 (62%) of 37 patients tested positive for hepatitis C virus-RNA in saliva, using polymerase chain reaction analysis. A slightly greater proportion had a sporadic rather than a parenteral origin of chronic hepatitis C. These results provide a biological basis for saliva as a possible source of hepatitis C virus (HCV) infection, but do not necessarily imply transmission by this route.
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Selected References
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- Fried M. W., Shindo M., Fong T. L., Fox P. C., Hoofnagle J. H., Di Bisceglie A. M. Absence of hepatitis C viral RNA from saliva and semen of patients with chronic hepatitis C. Gastroenterology. 1992 Apr;102(4 Pt 1):1306–1308. [PubMed] [Google Scholar]
- Hsu H. H., Wright T. L., Luba D., Martin M., Feinstone S. M., Garcia G., Greenberg H. B. Failure to detect hepatitis C virus genome in human secretions with the polymerase chain reaction. Hepatology. 1991 Nov;14(5):763–767. doi: 10.1002/hep.1840140504. [DOI] [PubMed] [Google Scholar]
- Komiyama K., Moro I., Mastuda Y., Morshed S. A., Nishioka M., Hayashi N., Shikata T. HCV in saliva of chronic hepatitis patients having dental treatment. Lancet. 1991 Aug 31;338(8766):572–573. doi: 10.1016/0140-6736(91)91137-j. [DOI] [PubMed] [Google Scholar]
- Takamatsu K., Koyanagi Y., Okita K., Yamamoto N. Hepatitis C virus RNA in saliva. Lancet. 1990 Dec 15;336(8729):1515–1515. doi: 10.1016/0140-6736(90)93229-i. [DOI] [PubMed] [Google Scholar]
- Wang J. T., Wang T. H., Lin J. T., Sheu J. C., Lin S. M., Chen D. S. Hepatitis C virus RNA in saliva of patients with post-transfusion hepatitis C infection. Lancet. 1991 Jan 5;337(8732):48–48. doi: 10.1016/0140-6736(91)93365-g. [DOI] [PubMed] [Google Scholar]
