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. 1993;34(2 Suppl):S142–S143. doi: 10.1136/gut.34.2_suppl.s142

Alpha interferon treatment of chronic hepatitis C in beta-thalassaemia.

V Di Marco 1, O Lo Iacono 1, M Capra 1, S Grutta 1, C Ciaccio 1, C Gerardi 1, A Maggio 1, D Renda 1, P Almasio 1, R Pisa 1, et al.
PMCID: PMC1374044  PMID: 8314484

Abstract

In this open, pilot study, interferon (IFN) alpha-2b seemed effective in the treatment of hepatitis C virus (HCV) infection in patients with beta-thalassaemia. In seven of nine patients who completed the study alanine aminotransferase activities returned to normal, and a completely stable response 24 months after treatment was seen in five. Liver biopsy specimen showed a clear reduction in portal, periportal, and lobular necroinflammation in all five cases. Three patients stopped treatment early because of side effects.

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