Abstract
To confirm the positive results of a preliminary trial, 26 patients with mixed cryoglobulinaemia were enrolled in a controlled, randomised, crossover trial with interferon alfa-2b. A significant improvement was seen in the purpura score and alanine aminotransferase activities during six months' treatment, and was associated with a significant decrease in cryocrit and a returning to normal of the lymphocyte CD4/CD8 ratio (in eight of nine patients). No significant variations were seen during the six month period without interferon. Only six patients withdrew from treatment, three because of side effects and three because of poor compliance.
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Selected References
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- Casato M., Laganà B., Antonelli G., Dianzani F., Bonomo L. Long-term results of therapy with interferon-alpha for type II essential mixed cryoglobulinemia. Blood. 1991 Dec 15;78(12):3142–3147. [PubMed] [Google Scholar]
- Ferri C., Greco F., Longombardo G., Palla P., Moretti A., Marzo E., Fosella P. V., Pasero G., Bombardieri S. Antibodies against hepatitis C virus in mixed cryoglobulinemia patients. Infection. 1991 Nov-Dec;19(6):417–420. doi: 10.1007/BF01726453. [DOI] [PubMed] [Google Scholar]
- Ferri C., Greco F., Longombardo G., Palla P., Moretti A., Marzo E., Fosella P. V., Pasero G., Bombardieri S. Antibodies to hepatitis C virus in patients with mixed cryoglobulinemia. Arthritis Rheum. 1991 Dec;34(12):1606–1610. doi: 10.1002/art.1780341221. [DOI] [PubMed] [Google Scholar]
- Ferri C., Greco F., Longombardo G., Palla P., Moretti A., Marzo E., Mazzoni A., Pasero G., Bombardieri S., Highfield P. Association between hepatitis C virus and mixed cryoglobulinemia [see comment]. Clin Exp Rheumatol. 1991 Nov-Dec;9(6):621–624. [PubMed] [Google Scholar]
- Ferri C., Gremignai G., Bombardieri S., Moriconi L., Pontrandolfo A., Vitali C., Fosella P. V., Pasero G. Plasma-exchange in mixed cryoglobulinemia. Effects on renal, liver and neurologic involvement. Ric Clin Lab. 1986 Apr-Jun;16(2):403–411. doi: 10.1007/BF02909369. [DOI] [PubMed] [Google Scholar]
- Ferri C., Marzo E., Longombardo G., Lombardini F., Greco F., Bombardieri S. Alpha interferon in the treatment of mixed cryoglobulinaemia patients. Eur J Cancer. 1991;27 (Suppl 4):S81–S82. doi: 10.1016/0277-5379(91)90583-y. [DOI] [PubMed] [Google Scholar]
- Ferri C., Moriconi L., Gremignai G., Migliorini P., Paleologo G., Fosella P. V., Bombardieri S. Treatment of the renal involvement in mixed cryoglobulinemia with prolonged plasma exchange. Nephron. 1986;43(4):246–253. doi: 10.1159/000183849. [DOI] [PubMed] [Google Scholar]
- Ferri C., Pietrogrande M., Cecchetti R., Tavoni A., Cefalo A., Buzzetti G., Vitali C., Bombardieri S. Low-antigen-content diet in the treatment of patients with mixed cryoglobulinemia. Am J Med. 1989 Nov;87(5):519–524. doi: 10.1016/s0002-9343(89)80607-2. [DOI] [PubMed] [Google Scholar]