Table 1. Genes associated with cofactor biosynthesis identified via KEGG enrichment analysis.
| Gene_ID | Gene | Annotation |
|
B. abortus A19 | ||
|
DR186_RS02480 |
fabG |
3-Oxoacyl-[acyl-carrier-protein] reductase |
|
DR186_RS02500 |
fabF |
Beta-ketoacyl-ACP synthase II |
|
DR186_RS03970 |
hemB |
Porphobilinogen synthase |
|
DR186_RS04855 |
- |
NAD kinase |
|
DR186_RS05220 |
- |
NAD+ synthase |
|
DR186_RS05310 |
folP |
Dihydropteroate synthase |
|
DR186_RS05315 |
folB |
Dihydroneopterin aldolase |
|
DR186_RS05320 |
folK |
2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase |
|
DR186_RS05560 |
folE |
GTP cyclohydrolase I FolE |
|
DR186_RS05845 |
lipA |
Lipoyl synthase |
|
DR186_RS05980 |
fabZ |
3-Hydroxyacyl-ACP dehydratase FabZ |
|
DR186_RS07155 |
- |
Dihydrofolate reductase |
|
DR186_RS07600 |
carA |
Glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit |
|
DR186_RS07620 |
carB |
Carbamoyl-phosphate synthase large subunit |
|
DR186_RS07930 |
hemF |
Oxygen-dependent coproporphyrinogen oxidase |
|
DR186_RS08585 |
- |
Adenylosuccinate synthase |
|
DR186_RS08925 |
- |
Thiamine diphosphokinase |
|
DR186_RS09320 |
- |
Nicotinate-nucleotide adenylyltransferase |
|
DR186_RS09495 |
ubiG |
Bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG |
|
DR186_RS09555 |
hemC |
Hydroxymethylbilane synthase |
|
DR186_RS10440 |
hemJ |
Protoporphyrinogen oxidase HemJ |
|
DR186_RS10445 |
hemE |
Uroporphyrinogen decarboxylase |
|
DR186_RS10470 |
coaE |
Dephospho-CoA kinase |
|
DR186_RS10555 |
coaA |
Type I pantothenate kinase |
|
DR186_RS10905 |
metK |
Methionine adenosyltransferase |
|
DR186_RS10965 |
fabB |
Beta-ketoacyl-ACP synthase I |
|
DR186_RS10650 |
- |
Folylpolyglutamate synthase/dihydrofolate synthase family protein |
|
DR186_RS01815 |
hemA |
5-Aminolevulinate synthase |
|
DR186_RS06015 |
pyrH |
UMP kinase |
|
DR186_RS09550 |
- |
Uroporphyrinogen-III synthase |
|
DR186_RS03995 |
glyA |
Serine hydroxymethyltransferase |
|
DR186_RS05705 |
coaD |
Pantetheine-phosphate adenylyltransferase |
|
DR186_RS02275 |
ubiA |
4-hydroxybenzoate octaprenyltransferase |
|
DR186_RS04010 |
- |
Riboflavin synthase |
|
DR186_RS09610 |
- |
Ubiquinone biosynthesis hydroxylase |
|
DR186_RS04815 |
- |
Cysteine desulfurase family protein |
|
DR186_RS00585 |
pncB |
Nicotinate phosphoribosyltransferase |
|
DR186_RS03635 |
ndk |
Nucleoside-diphosphate kinase |
|
DR186_RS05895 |
- |
CTP synthase |
|
DR186_RS12010 |
- |
Bifunctional riboflavin kinase/FAD synthetase |
|
DR186_RS13325 |
folD |
Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD |
|
DR186_RS14195 |
- |
Aspartate carbamoyltransferase catalytic subunit |
|
DR186_RS14245 |
lipB |
Lipoyl(octanoyl) transferase LipB |
|
DR186_RS16105 |
ubiE |
Bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1%2C4-benzoquinol methylase UbiE |
|
DR186_RS13420 |
- |
Glutamate--cysteine ligase |
|
DR186_RS11415 |
hemH |
Ferrochelatase |
|
DR186_RS16095 |
coaBC |
Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC |
|
B. abortus S2308 | ||
|
BAB_RS16450 |
pncB |
Nicotinate phosphoribosyltransferase |
|
BAB_RS17600 |
hemA |
5-Aminolevulinate synthase |
|
BAB_RS18030 |
ubiA |
4-Hydroxybenzoate octaprenyltransferase |
|
BAB_RS18225 |
fabG |
3-Oxoacyl-[acyl-carrier-protein] reductase |
|
BAB_RS18235 |
fabF |
Beta-ketoacyl-ACP synthase II |
|
BAB_RS19675 |
glyA |
Serine hydroxymethyltransferase |
|
BAB_RS19685 |
ribD |
Bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD |
|
BAB_RS19690 |
- |
Riboflavin synthase |
|
BAB_RS20070 |
purB |
Adenylosuccinate lyase |
|
BAB_RS20505 |
- |
NAD kinase |
|
BAB_RS20875 |
- |
NAD+ synthase |
|
BAB_RS20880 |
gltX |
Glutamate--tRNA ligase |
|
BAB_RS20950 |
folP |
Dihydropteroate synthase |
|
BAB_RS20955 |
folB |
Dihydroneopterin aldolase |
|
BAB_RS20960 |
folK |
2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase |
|
BAB_RS21170 |
folE |
GTP cyclohydrolase I FolE |
|
BAB_RS21285 |
coaD |
Pantetheine-phosphate adenylyltransferase |
|
BAB_RS21415 |
lipA |
Lipoyl synthase |
|
BAB_RS21545 |
fabZ |
3-Hydroxyacyl-ACP dehydratase FabZ |
|
BAB_RS21580 |
pyrH |
UMP kinase |
|
BAB_RS22685 |
- |
Dihydrofolate reductase |
|
BAB_RS23085 |
carA |
Glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit |
|
BAB_RS23105 |
carB |
Carbamoyl-phosphate synthase large subunit |
|
BAB_RS23385 |
hemF |
Oxygen-dependent coproporphyrinogen oxidase |
|
BAB_RS24715 |
- |
Nicotinate-nucleotide adenylyltransferase |
|
BAB_RS24870 |
ubiG |
Bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG |
|
BAB_RS24930 |
- |
Uroporphyrinogen-III synthase |
|
BAB_RS24935 |
hemC |
Hydroxymethylbilane synthase |
|
BAB_RS24990 |
- |
Ubiquinone biosynthesis hydroxylase |
|
BAB_RS25770 |
hemJ |
Protoporphyrinogen oxidase HemJ |
|
BAB_RS25775 |
hemE |
Uroporphyrinogen decarboxylase |
|
BAB_RS25880 |
coaA |
Type I pantothenate kinase |
|
BAB_RS25960 |
- |
Bifunctional folylpolyglutamate synthase/dihydrofolate synthase |
|
BAB_RS26220 |
metK |
Methionine adenosyltransferase |
|
BAB_RS26285 |
fabB |
Beta-ketoacyl-ACP synthase I |
|
BAB_RS27285 |
- |
Bifunctional riboflavin kinase/FAD synthetase |
|
BAB_RS28550 |
folD |
Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD |
|
BAB_RS29425 |
lipB |
Lipoyl(octanoyl) transferase LipB |
|
BAB_RS31170 |
coaBC |
Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC |
|
BAB_RS31180 |
ubiE |
Bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1%2C4-benzoquinol methylase UbiE |