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. 1993 Apr;34(4):517–524. doi: 10.1136/gut.34.4.517

Familial empirical risks for inflammatory bowel disease: differences between Jews and non-Jews.

H Yang 1, C McElree 1, M P Roth 1, F Shanahan 1, S R Targan 1, J I Rotter 1
PMCID: PMC1374314  PMID: 8491401

Abstract

The Jewish population has an increased frequency of inflammatory bowel disease compared with their non-Jewish neighbours. Genetic factors have been implicated in the aetiology of this disorder and may contribute to ethnic differences. This study determined the familial empirical risks for inflammatory bowel disease in the first degree relatives of inflammatory bowel disease probands (for both Jews and non-Jews) for the purpose of accurate genetic counselling and genetic analysis. A total of 527 inflammatory bowel disease patients from Southern California (291 Jews and 236 non-Jews) were questioned about inflammatory bowel disease in their first degree relatives (a total of 2493 individuals). Since inflammatory bowel disease has a variable and late age of onset, age specific incidence data were used to estimate the life time risks and to make valid comparisons between the different groups. In the first degree relatives of non-Jewish probands, the life time risks for inflammatory bowel disease were 5.2% and 1.6% when probands had Crohn's disease and ulcerative colitis respectively. These values were consistently lower than the corresponding risks for relatives of Jewish patients -7.8% and 4.5% for Crohn's disease and ulcerative colitis probands respectively (p value for comparison between Jews and non-Jews: 0.028; between ulcerative colitis and Crohn's disease: 0.005). These data provide the requisite basis for genetic counselling for these disorders in the white American population. In addition, these different empirical risks for relatives of Jewish and non-Jewish probands allow rejection of single Mendelian gene models for inflammatory bowel disease, but are consistent with several alternative genetic models.

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Selected References

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  1. Brahme F., Lindström C., Wenckert A. Crohn's disease in a defined population. An epidemiological study of incidence, prevalence, mortality, and secular trends in the city of Malmö, Sweden. Gastroenterology. 1975 Aug;69(2):342–351. [PubMed] [Google Scholar]
  2. Calkins B. M., Lilienfeld A. M., Garland C. F., Mendeloff A. I. Trends in incidence rates of ulcerative colitis and Crohn's disease. Dig Dis Sci. 1984 Oct;29(10):913–920. doi: 10.1007/BF01312480. [DOI] [PubMed] [Google Scholar]
  3. Farmer R. G., Michener W. M., Mortimer E. A. Studies of family history among patients with inflammatory bowel disease. Clin Gastroenterol. 1980 May;9(2):271–277. [PubMed] [Google Scholar]
  4. Gilat T., Ribak J., Benaroya Y., Zemishlany Z., Weissman I. Ulcerative colitis in the Jewish population of Tel-Aviv Jafo. I. Epidemiology. Gastroenterology. 1974 Mar;66(3):335–342. [PubMed] [Google Scholar]
  5. Gollop J. H., Phillips S. F., Melton L. J., 3rd, Zinsmeister A. R. Epidemiologic aspects of Crohn's disease: a population based study in Olmsted County, Minnesota, 1943-1982. Gut. 1988 Jan;29(1):49–56. doi: 10.1136/gut.29.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hellers G. Crohn's disease in Stockholm county 1955-1974. A study of epidemiology, results of surgical treatment and long-term prognosis. Acta Chir Scand Suppl. 1979;490:1–84. [PubMed] [Google Scholar]
  7. KIRSNER J. B., SPENCER J. A. FAMILY OCCURRENCES OF ULCERATIVE COLITIS, REGIONAL ENTERITIS, AND ILEOCOLITIS. Ann Intern Med. 1963 Aug;59:133–144. doi: 10.7326/0003-4819-59-2-133. [DOI] [PubMed] [Google Scholar]
  8. Krawiec J., Odes H. S., Lasry Y., Krugliak P., Weitzman S. Aspects of the epidemiology of Crohn's disease in the Jewish population in Beer Sheva, Israel. Isr J Med Sci. 1984 Jan;20(1):16–21. [PubMed] [Google Scholar]
  9. Köbberling J. Untersuchungen zur Genetik des Diabetes mellitus. Eine geeignete Methode zur Durchführung von Alterskorrekturen. Diabetologia. 1969 Dec;5(6):392–396. doi: 10.1007/BF00427977. [DOI] [PubMed] [Google Scholar]
  10. Küster W., Pascoe L., Purrmann J., Funk S., Majewski F. The genetics of Crohn disease: complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives. Am J Med Genet. 1989 Jan;32(1):105–108. doi: 10.1002/ajmg.1320320122. [DOI] [PubMed] [Google Scholar]
  11. Lashner B. A., Evans A. A., Kirsner J. B., Hanauer S. B. Prevalence and incidence of inflammatory bowel disease in family members. Gastroenterology. 1986 Dec;91(6):1396–1400. doi: 10.1016/0016-5085(86)90193-9. [DOI] [PubMed] [Google Scholar]
  12. Monsén U., Broström O., Nordenvall B., Sörstad J., Hellers G. Prevalence of inflammatory bowel disease among relatives of patients with ulcerative colitis. Scand J Gastroenterol. 1987 Mar;22(2):214–218. doi: 10.3109/00365528708991882. [DOI] [PubMed] [Google Scholar]
  13. Monsén U., Iselius L., Johansson C., Hellers G. Evidence for a major additive gene in ulcerative colitis. Clin Genet. 1989 Dec;36(6):411–414. [PubMed] [Google Scholar]
  14. Novis B. H., Marks I. N., Bank S., Louw J. H. Incidence of Crohn's disease at Groote Schuur Hospital during 1970-1974. S Afr Med J. 1975 Apr 19;49(17):693–697. [PubMed] [Google Scholar]
  15. Odes H. S., Fraser D., Krawiec J. Incidence of idiopathic ulcerative colitis in Jewish population subgroups in the Beer Sheva region of Israel. Am J Gastroenterol. 1987 Sep;82(9):854–858. [PubMed] [Google Scholar]
  16. Odes H. S., Fraser D., Krawiec J. Ulcerative colitis in the Jewish population of southern Israel 1961-1985: epidemiological and clinical study. Gut. 1987 Dec;28(12):1630–1636. doi: 10.1136/gut.28.12.1630. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Odes H. S., Fraser D., Krugliak P., Fenyves D., Fraser G. M., Sperber A. D. Inflammatory bowel disease in the Bedouin Arabs of southern Israel: rarity of diagnosis and clinical features. Gut. 1991 Sep;32(9):1024–1026. doi: 10.1136/gut.32.9.1024. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Orholm M., Munkholm P., Langholz E., Nielsen O. H., Sørensen T. I., Binder V. Familial occurrence of inflammatory bowel disease. N Engl J Med. 1991 Jan 10;324(2):84–88. doi: 10.1056/NEJM199101103240203. [DOI] [PubMed] [Google Scholar]
  19. Roth M. P., Petersen G. M., McElree C., Feldman E., Rotter J. I. Geographic origins of Jewish patients with inflammatory bowel disease. Gastroenterology. 1989 Oct;97(4):900–904. doi: 10.1016/0016-5085(89)91495-9. [DOI] [PubMed] [Google Scholar]
  20. Roth M. P., Petersen G. M., McElree C., Vadheim C. M., Panish J. F., Rotter J. I. Familial empiric risk estimates of inflammatory bowel disease in Ashkenazi Jews. Gastroenterology. 1989 Apr;96(4):1016–1020. doi: 10.1016/0016-5085(89)91618-1. [DOI] [PubMed] [Google Scholar]
  21. Rozen P., Zonis J., Yekutiel P., Gilat T. Crohn's disease in the Jewish population of Tel-Aviv-Yafo. Epidemiologic and clinical aspects. Gastroenterology. 1979 Jan;76(1):25–30. [PubMed] [Google Scholar]
  22. Sadovnick A. D., Baird P. A. The familial nature of multiple sclerosis: age-corrected empiric recurrence risks for children and siblings of patients. Neurology. 1988 Jun;38(6):990–991. doi: 10.1212/wnl.38.6.990. [DOI] [PubMed] [Google Scholar]
  23. Sadovnick A. D., Irwin M. E., Baird P. A., Beattie B. L. Genetic studies on an Alzheimer clinic population. Genet Epidemiol. 1989;6(5):633–643. doi: 10.1002/gepi.1370060508. [DOI] [PubMed] [Google Scholar]
  24. Shanahan F., Duerr R. H., Rotter J. I., Yang H., Sutherland L. R., McElree C., Landers C. J., Targan S. R. Neutrophil autoantibodies in ulcerative colitis: familial aggregation and genetic heterogeneity. Gastroenterology. 1992 Aug;103(2):456–461. doi: 10.1016/0016-5085(92)90834-l. [DOI] [PubMed] [Google Scholar]
  25. Stonnington C. M., Phillips S. F., Melton L. J., 3rd, Zinsmeister A. R. Chronic ulcerative colitis: incidence and prevalence in a community. Gut. 1987 Apr;28(4):402–409. doi: 10.1136/gut.28.4.402. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Tillil H., Köbberling J. Age-corrected empirical genetic risk estimates for first-degree relatives of IDDM patients. Diabetes. 1987 Jan;36(1):93–99. doi: 10.2337/diab.36.1.93. [DOI] [PubMed] [Google Scholar]
  27. Tysk C., Lindberg E., Järnerot G., Flodérus-Myrhed B. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut. 1988 Jul;29(7):990–996. doi: 10.1136/gut.29.7.990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Weterman I. T., Peña A. S. Familial incidence of Crohn's disease in The Netherlands and a review of the literature. Gastroenterology. 1984 Mar;86(3):449–452. [PubMed] [Google Scholar]
  29. Zlotogora J., Zimmerman J., Rachmilewitz D. Crohn's disease in Ashkenazi Jews. Gastroenterology. 1990 Jul;99(1):286–287. doi: 10.1016/0016-5085(90)91273-9. [DOI] [PubMed] [Google Scholar]

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