Skip to main content
NCBI home page
Gut logoLink to Gut
. 1993 Nov;34(11):1636–1638. doi: 10.1136/gut.34.11.1636

Crohn's disease with pulmonary involvement in a 3 year old boy.

C J Calder 1, D Lacy 1, F Raafat 1, P H Weller 1, I W Booth 1
PMCID: PMC1374439  PMID: 8244155

Abstract

Extra-intestinal or metastatic Crohn's disease is being recognised increasingly, most commonly in the skin and genitourinary system. Only very rarely has it been reported in the lung. A 3 year old boy who presented with swollen gums and a persistent abnormality on his chest x ray is reported. Lung biopsy specimens showed multiple non-caseating epithelioid granulomas. Subsequent investigation showed the presence of intestinal Crohn's disease. The evidence for abnormal lung function in Crohn's disease and the possible pathogenesis of metastatic pulmonary Crohn's disease are discussed.

Full text

PDF
1636

Images in this article

1636Figure 1
on p.1636
1637Figure 2
on p.1637

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bambery P., Kaur U., Bhusnurmath S. R., Dilawari J. B. Familial idiopathic granulomatosis: sarcoidosis and Crohn's disease in two Indian families. Thorax. 1991 Dec;46(12):919–921. doi: 10.1136/thx.46.12.919. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bonniere P., Wallaert B., Cortot A., Marchandise X., Riou Y., Tonnel A. B., Colombel J. F., Voisin C., Paris J. C. Latent pulmonary involvement in Crohn's disease: biological, functional, bronchoalveolar lavage and scintigraphic studies. Gut. 1986 Aug;27(8):919–925. doi: 10.1136/gut.27.8.919. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bookman A. A., Gould M. I., Barrowman J. A., Chittal S. M. Periosteal new bone formation and disseminated granulomatosis in a patient with Crohn's disease. Am J Med. 1988 Feb;84(2):330–333. doi: 10.1016/0002-9343(88)90435-4. [DOI] [PubMed] [Google Scholar]
  4. Eade O. E., Smith C. L., Alexander J. R., Whorwell P. J. Pulmonary function in patients with inflammatory bowel disease. Am J Gastroenterol. 1980 Feb;73(2):154–156. [PubMed] [Google Scholar]
  5. Gould S. R., Handley A. J., Barnardo D. E. Rectal and gastric involvement in a case of sarcoidosis. Gut. 1973 Dec;14(12):971–973. doi: 10.1136/gut.14.12.971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Heatley R. V., Thomas P., Prokipchuk E. J., Gauldie J., Sieniewicz D. J., Bienenstock J. Pulmonary function abnormalities in patients with inflammatory bowel disease. Q J Med. 1982 Summer;51(203):241–250. [PubMed] [Google Scholar]
  7. Henrion F., Bretagne M. C., Neimann L., Flechon P. E., Canton P., Hoeffel J. C. Association exceptionnelle de lésions pulmonaires, cutanées et d'une iléite terminale chez un enfant de 11 ans. J Radiol. 1982 Feb;63(2):123–126. [PubMed] [Google Scholar]
  8. Kayser K., Probst F., Gabius H. J., Müller K. M. Are there characteristic alterations in lung tissue associated with Crohn's disease? Pathol Res Pract. 1990 Aug;186(4):485–490. doi: 10.1016/s0344-0338(11)80468-1. [DOI] [PubMed] [Google Scholar]
  9. Konda J., Ruth M., Sassaris M., Hunter F. M. Sarcoidosis of the stomach and rectum. Am J Gastroenterol. 1980 Jun;73(6):516–518. [PubMed] [Google Scholar]
  10. Lally M. R., Orenstein S. R., Cohen B. A. Crohn's disease of the vulva in an 8-year-old girl. Pediatr Dermatol. 1988 May;5(2):103–106. doi: 10.1111/j.1525-1470.1988.tb01148.x. [DOI] [PubMed] [Google Scholar]
  11. Lavery H. A., Pinkerton J. H., Sloan J. Crohn's disease of the vulva--two further cases. Br J Dermatol. 1985 Sep;113(3):359–363. doi: 10.1111/j.1365-2133.1985.tb02091.x. [DOI] [PubMed] [Google Scholar]
  12. Lemann M., Messing B., D'Agay F., Modigliani R. Crohn's disease with respiratory tract involvement. Gut. 1987 Dec;28(12):1669–1672. doi: 10.1136/gut.28.12.1669. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Nunez-Gornes J. F., Tewksbury D. A. Serum angiotensin-converting-enzyme in Crohn's disease. Am J Gastroenterol. 1981 May;75(5):384–385. [PubMed] [Google Scholar]
  14. Puntis J. W., Candy D. C., Alexander-Williams J., Kelsey A. Widespread cutaneous Crohn's disease presenting in childhood. J Pediatr Gastroenterol Nutr. 1985 Oct;4(5):826–828. doi: 10.1097/00005176-198510000-00025. [DOI] [PubMed] [Google Scholar]
  15. Puntis J. W., Tarlow M. J., Raafat F., Booth I. W. Crohn's disease of the lung. Arch Dis Child. 1990 Nov;65(11):1270–1271. doi: 10.1136/adc.65.11.1270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Schulman D., Beck L. S., Roberts I. M., Schwartz A. M. Crohn's disease of the vulva. Am J Gastroenterol. 1987 Dec;82(12):1328–1330. [PubMed] [Google Scholar]
  17. Shah S. M., Texter E. C., Jr, White H. J. Inflammatory bowel disease associated with granulomatous lung disease: report of a case with endoscopic findings. Gastrointest Endosc. 1976 Nov;23(2):98–99. doi: 10.1016/s0016-5107(76)73607-1. [DOI] [PubMed] [Google Scholar]
  18. Sprague R., Harper P., McClain S., Trainer T., Beeken W. Disseminated gastrointestinal sarcoidosis. Case report and review of the literature. Gastroenterology. 1984 Aug;87(2):421–425. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES