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. 1994 Mar;35(3):426–428. doi: 10.1136/gut.35.3.426

Drug induced lymphocytic colitis.

L Beaugerie 1, J Luboinski 1, N Brousse 1, J Cosnes 1, F P Chatelet 1, J P Gendre 1, Y Le Quintrec 1
PMCID: PMC1374604  PMID: 8150360

Abstract

Three cases are presented of lymphocytic colitis with chronic diarrhoea concurrent with longterm use of Cyclo 3 Fort, a phlebotonic drug used in France. The histological and immunopathological features of lymphocytic colitis are described. We show that lymphocytic colitis is drug induced, particularly in one patient where the immunopathological features of mucosal immune cell activation were induced by drug rechallenge. It is concluded that lymphocytic colitis may be drug induced, secondary to a chronic activation of the mucosal immune system by one or several components of the drug.

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Selected References

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  1. Cerf-Bensussan N., Quaroni A., Kurnick J. T., Bhan A. K. Intraepithelial lymphocytes modulate Ia expression by intestinal epithelial cells. J Immunol. 1984 May;132(5):2244–2252. [PubMed] [Google Scholar]
  2. Chagnon J. P., Cerf M. Simvastatin-induced protein-losing enteropathy. Am J Gastroenterol. 1992 Feb;87(2):257–257. [PubMed] [Google Scholar]
  3. Choy M. Y., Walker-Smith J. A., Williams C. B., MacDonald T. T. Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis. Gut. 1990 Dec;31(12):1365–1370. doi: 10.1136/gut.31.12.1365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Giardiello F. M., Hansen F. C., 3rd, Lazenby A. J., Hellman D. B., Milligan F. D., Bayless T. M., Yardley J. H. Collagenous colitis in setting of nonsteroidal antiinflammatory drugs and antibiotics. Dig Dis Sci. 1990 Feb;35(2):257–260. doi: 10.1007/BF01536772. [DOI] [PubMed] [Google Scholar]
  5. Kutlu T., Brousse N., Rambaud C., Le Deist F., Schmitz J., Cerf-Bensussan N. Numbers of T cell receptor (TCR) alpha beta+ but not of TcR gamma delta+ intraepithelial lymphocytes correlate with the grade of villous atrophy in coeliac patients on a long term normal diet. Gut. 1993 Feb;34(2):208–214. doi: 10.1136/gut.34.2.208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lazenby A. J., Yardley J. H., Giardiello F. M., Jessurun J., Bayless T. M. Lymphocytic ("microscopic") colitis: a comparative histopathologic study with particular reference to collagenous colitis. Hum Pathol. 1989 Jan;20(1):18–28. doi: 10.1016/0046-8177(89)90198-6. [DOI] [PubMed] [Google Scholar]
  7. MacDonald T. T., Weinel A., Spencer J. HLA-DR expression in human fetal intestinal epithelium. Gut. 1988 Oct;29(10):1342–1348. doi: 10.1136/gut.29.10.1342. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Ouyahya F., Codjovi P., Machet M. C., Oliver J. M., Dorval E. D., Metman E. H. Diarrhée au Cyclo 3 fort et colite lymphocytaire. Gastroenterol Clin Biol. 1993;17(1):65–66. [PubMed] [Google Scholar]
  9. Riddell R. H., Tanaka M., Mazzoleni G. Non-steroidal anti-inflammatory drugs as a possible cause of collagenous colitis: a case-control study. Gut. 1992 May;33(5):683–686. doi: 10.1136/gut.33.5.683. [DOI] [PMC free article] [PubMed] [Google Scholar]

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