Skip to main content
NCBI home page
Gut logoLink to Gut
. 1994 Jun;35(6):769–770. doi: 10.1136/gut.35.6.769

Lewis phenotype, secretor status, and coeliac disease.

W Dickey 1, J D Wylie 1, J S Collins 1, K G Porter 1, R G Watson 1, J C McLoughlin 1
PMCID: PMC1374875  PMID: 8020802

Abstract

Patients who cannot secrete ABO and Lewis blood group antigens into body fluids, an ability controlled by a single gene on chromosome 19, are known to be at increased risk of certain autoimmune diseases associated with human leucocyte antigen (HLA) markers. This study investigated the possibility of an association with coeliac disease using red cell Lewis (Le) blood group phenotype to infer secretor status. Among 73 patients with coeliac disease who had Le a or b antigen, 48% were non-secretors (Le a + b-) compared with 27% of 137 blood donors (p = 0.004: odds ratio 2.49, 95% confidence intervals 1.37 to 4.51) and 26% of 62 medical and nursing staff controls (p = 0.014: odds ratio 2.65, 95% confidence intervals 1.27 to 5.50). Clinical characteristics did not differ between secretors and non-secretors with coeliac disease. Thus, the non-secretor state is significantly associated with coeliac disease, suggesting that genes on chromosome 19 may directly or indirectly participate in conferring susceptibility.

Full text

PDF
769

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arató A., Kósnai I., Szönyi L., Tóth M. Frequent past exposure to adenovirus 12 in coeliac disease. Acta Paediatr Scand. 1991 Nov;80(11):1101–1102. doi: 10.1111/j.1651-2227.1991.tb11792.x. [DOI] [PubMed] [Google Scholar]
  2. Blackwell C. C., James V. S., Weir D. M., Gemmill J. D., Patrick A. W., Collier A., Clarke B. F. Secretor state of patients with insulin dependent or non-insulin-dependent diabetes mellitus. Br Med J (Clin Res Ed) 1987 Oct 24;295(6605):1024–1025. doi: 10.1136/bmj.295.6605.1024. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Blackwell C. C., Jonsdottir K., Weir D. M., Hanson M. F., Cartwright K. A., Stewart J., Jones D., Mohammed I. Blood group, secretor status and susceptibility to bacterial meningitis. FEMS Microbiol Immunol. 1989 Jun;1(6-7):351–356. doi: 10.1111/j.1574-6968.1989.tb02420.x. [DOI] [PubMed] [Google Scholar]
  4. Blackwell C. C., Weir D. M., James V. S., Cartwright K. A., Stuart J. M., Jones D. M. The Stonehouse study: secretor status and carriage of Neisseria species. Epidemiol Infect. 1989 Feb;102(1):1–10. doi: 10.1017/s0950268800029629. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Collier A., Patrick A. W., Toft A. D., Blackwell C. C., James V., Weir D. M. Increased prevalence of non-secretors in patients with Graves' disease: evidence for an infective aetiology? Br Med J (Clin Res Ed) 1988 Apr 23;296(6630):1162–1162. doi: 10.1136/bmj.296.6630.1162. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dickey W., Collins J. S., Watson R. G., Sloan J. M., Porter K. G. Secretor status and Helicobacter pylori infection are independent risk factors for gastroduodenal disease. Gut. 1993 Mar;34(3):351–353. doi: 10.1136/gut.34.3.351. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hannigan M., Bourke M., Stevens F. M., McCarthy C. F. Gm typing of Irish coeliac patients and controls does not help locate the "second" coeliac gene. Ir J Med Sci. 1991 Feb;160(2):57–58. doi: 10.1007/BF02947649. [DOI] [PubMed] [Google Scholar]
  8. Kagnoff M. F., Weiss J. B., Brown R. J., Lee T., Schanfield M. S. Immunoglobulin allotype markers in gluten-sensitive enteropathy. Lancet. 1983 Apr 30;1(8331):952–953. doi: 10.1016/s0140-6736(83)92080-9. [DOI] [PubMed] [Google Scholar]
  9. Langman M. J., Banwell J. G., Stewart J. S., Robson E. B. ABO blood groups, secretor status, and intestinal alkaline phosphatase concentrations in patients with celiac disease. Gastroenterology. 1969 Jul;57(1):19–23. [PubMed] [Google Scholar]
  10. Mahon J., Blair G. E., Wood G. M., Scott B. B., Losowsky M. S., Howdle P. D. Is persistent adenovirus 12 infection involved in coeliac disease? A search for viral DNA using the polymerase chain reaction. Gut. 1991 Oct;32(10):1114–1116. doi: 10.1136/gut.32.10.1114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Raza M. W., Blackwell C. C., Molyneaux P., James V. S., Ogilvie M. M., Inglis J. M., Weir D. M. Association between secretor status and respiratory viral illness. BMJ. 1991 Oct 5;303(6806):815–818. doi: 10.1136/bmj.303.6806.815. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Shinebaum R., Blackwell C. C., Forster P. J., Hurst N. P., Weir D. M., Nuki G. Non-secretion of ABO blood group antigens as a host susceptibility factor in the spondyloarthropathies. Br Med J (Clin Res Ed) 1987 Jan 24;294(6566):208–210. doi: 10.1136/bmj.294.6566.208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Waissbluth J. G., Langman M. J. ABO blood groups, secretor status, salivary protein, and serum and salivary immunoglobulin concentrations. Gut. 1971 Aug;12(8):646–649. doi: 10.1136/gut.12.8.646. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES