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. 1994 Oct;35(10):1379–1384. doi: 10.1136/gut.35.10.1379

Gastric T lymphocyte responses to Helicobacter pylori in patients with H pylori colonisation.

X J Fan 1, A Chua 1, C N Shahi 1, J McDevitt 1, P W Keeling 1, D Kelleher 1
PMCID: PMC1375009  PMID: 7959191

Abstract

Helicobacter pylori has been identified as a dominant factor in the pathogenesis of duodenal ulcer. The aim of this study was to examine peripheral blood and gastric lymphocyte proliferation and cytokine production in patients with H pylori colonisation. Sixty five dyspeptic patients attending for endoscopy were studied; 35 of these were H pylori positive and 30 H pylori negative as assessed by culture, histology, and rapid urease test. H pylori antigen was capable of stimulating peripheral blood lymphocyte proliferative responses even in H pylori negative patients. Peripheral blood lymphocyte proliferative responses to H pylori (but not to purified protein derivative or phythaemagglutinin) were significantly lower in H pylori positive than H pylori negative patients. Similarly, antigen specific proliferative responses and interferon gamma production by gastric lamina propria lymphocytes were also depressed in H pylori positive patients compared with H pylori negative patients. CD8 and CD22 positive lamina propria lymphocytes were increased in H pylori positive patients. These data show that antigen specific responses to H pylori are significantly lower in H pylori positive patients and could indicate activation of antigen specific suppression.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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