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. 1994 Nov;35(11):1509–1516. doi: 10.1136/gut.35.11.1509

Cell biology of liver endothelial and Kupffer cells.

B Smedsrød 1, P J De Bleser 1, F Braet 1, P Lovisetti 1, K Vanderkerken 1, E Wisse 1, A Geerts 1
PMCID: PMC1375602  PMID: 7828963

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Selected References

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  1. Albelda S. M. Role of integrins and other cell adhesion molecules in tumor progression and metastasis. Lab Invest. 1993 Jan;68(1):4–17. [PubMed] [Google Scholar]
  2. Andus T., Geiger T., Hirano T., Kishimoto T., Tran-Thi T. A., Decker K., Heinrich P. C. Regulation of synthesis and secretion of major rat acute-phase proteins by recombinant human interleukin-6 (BSF-2/IL-6) in hepatocyte primary cultures. Eur J Biochem. 1988 Apr 15;173(2):287–293. doi: 10.1111/j.1432-1033.1988.tb13997.x. [DOI] [PubMed] [Google Scholar]
  3. Auerbach R., Lu W. C., Pardon E., Gumkowski F., Kaminska G., Kaminski M. Specificity of adhesion between murine tumor cells and capillary endothelium: an in vitro correlate of preferential metastasis in vivo. Cancer Res. 1987 Mar 15;47(6):1492–1496. [PubMed] [Google Scholar]
  4. Barbera-Guillem E., Weiss L. Cancer-cell traffic in the liver. III Lethal deformation of B16 melanoma cells in liver sinusoids. Int J Cancer. 1993 Jul 9;54(5):880–884. doi: 10.1002/ijc.2910540526. [DOI] [PubMed] [Google Scholar]
  5. Bauer J., Birmelin M., Northoff G. H., Northemann W., Tran-Thi T. A., Ueberberg H., Decker K., Heinrich P. C. Induction of rat alpha 2-macroglobulin in vivo and in hepatocyte primary cultures: synergistic action of glucocorticoids and a Kupffer cell-derived factor. FEBS Lett. 1984 Nov 5;177(1):89–94. doi: 10.1016/0014-5793(84)80987-4. [DOI] [PubMed] [Google Scholar]
  6. Beutler B., Cerami A. The biology of cachectin/TNF--a primary mediator of the host response. Annu Rev Immunol. 1989;7:625–655. doi: 10.1146/annurev.iy.07.040189.003205. [DOI] [PubMed] [Google Scholar]
  7. Bevilacqua M. P., Stengelin S., Gimbrone M. A., Jr, Seed B. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science. 1989 Mar 3;243(4895):1160–1165. doi: 10.1126/science.2466335. [DOI] [PubMed] [Google Scholar]
  8. Billiar T. R., Curran R. D., Stuehr D. J., West M. A., Bentz B. G., Simmons R. L. An L-arginine-dependent mechanism mediates Kupffer cell inhibition of hepatocyte protein synthesis in vitro. J Exp Med. 1989 Apr 1;169(4):1467–1472. doi: 10.1084/jem.169.4.1467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Blomhoff R., Drevon C. A., Eskild W., Helgerud P., Norum K. R., Berg T. Clearance of acetyl low density lipoprotein by rat liver endothelial cells. Implications for hepatic cholesterol metabolism. J Biol Chem. 1984 Jul 25;259(14):8898–8903. [PubMed] [Google Scholar]
  10. Bouwens L., Baekeland M., De Zanger R., Wisse E. Quantitation, tissue distribution and proliferation kinetics of Kupffer cells in normal rat liver. Hepatology. 1986 Jul-Aug;6(4):718–722. doi: 10.1002/hep.1840060430. [DOI] [PubMed] [Google Scholar]
  11. Bouwens L., Baekeland M., Wisse E. Importance of local proliferation in the expanding Kupffer cell population of rat liver after zymosan stimulation and partial hepatectomy. Hepatology. 1984 Mar-Apr;4(2):213–219. doi: 10.1002/hep.1840040208. [DOI] [PubMed] [Google Scholar]
  12. Bouwens L., Geerts A., Van Bossuyt H., Wisse E. Recent insights into the function of hepatic sinusoidal cells. Neth J Med. 1987 Oct;31(3-4):129–148. [PubMed] [Google Scholar]
  13. Bouwens L., Knook D. L., Wisse E. Local proliferation and extrahepatic recruitment of liver macrophages (Kupffer cells) in partial-body irradiated rats. J Leukoc Biol. 1986 Jun;39(6):687–697. doi: 10.1002/jlb.39.6.687. [DOI] [PubMed] [Google Scholar]
  14. Bouwens L., Wisse E. Proliferation, kinetics, and fate of monocytes in rat liver during a zymosan-induced inflammation. J Leukoc Biol. 1985 May;37(5):531–543. doi: 10.1002/jlb.37.5.531. [DOI] [PubMed] [Google Scholar]
  15. Braet F., De Zanger R., Sasaoki T., Baekeland M., Janssens P., Smedsrød B., Wisse E. Assessment of a method of isolation, purification, and cultivation of rat liver sinusoidal endothelial cells. Lab Invest. 1994 Jun;70(6):944–952. [PubMed] [Google Scholar]
  16. Bresalier R. S., Hujanen E. S., Raper S. E., Roll F. J., Itzkowitz S. H., Martin G. R., Kim Y. S. An animal model for colon cancer metastasis: establishment and characterization of murine cell lines with enhanced liver-metastasizing ability. Cancer Res. 1987 Mar 1;47(5):1398–1406. [PubMed] [Google Scholar]
  17. Brown M. S., Goldstein J. L. Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu Rev Biochem. 1983;52:223–261. doi: 10.1146/annurev.bi.52.070183.001255. [DOI] [PubMed] [Google Scholar]
  18. Busam K. J., Bauer T. M., Bauer J., Gerok W., Decker K. Interleukin-6 release by rat liver macrophages. J Hepatol. 1990 Nov;11(3):367–373. doi: 10.1016/0168-8278(90)90223-e. [DOI] [PubMed] [Google Scholar]
  19. Butcher E. C. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell. 1991 Dec 20;67(6):1033–1036. doi: 10.1016/0092-8674(91)90279-8. [DOI] [PubMed] [Google Scholar]
  20. Carlos T. M., Harlan J. M. Membrane proteins involved in phagocyte adherence to endothelium. Immunol Rev. 1990 Apr;114:5–28. doi: 10.1111/j.1600-065x.1990.tb00559.x. [DOI] [PubMed] [Google Scholar]
  21. Clark S. A., Angus H. B., Cook H. B., George P. M., Oxner R. B., Fraser R. Defenestration of hepatic sinusoids as a cause of hyperlipoproteinaemia in alcoholics. Lancet. 1988 Nov 26;2(8622):1225–1227. doi: 10.1016/s0140-6736(88)90813-6. [DOI] [PubMed] [Google Scholar]
  22. Clement B., Grimaud J. A., Campion J. P., Deugnier Y., Guillouzo A. Cell types involved in collagen and fibronectin production in normal and fibrotic human liver. Hepatology. 1986 Mar-Apr;6(2):225–234. doi: 10.1002/hep.1840060212. [DOI] [PubMed] [Google Scholar]
  23. Clément B., Emonard H., Rissel M., Druguet M., Grimaud J. A., Herbage D., Bourel M., Guillouzo A. Cellular origin of collagen and fibronectin in the liver. Cell Mol Biol. 1984;30(5):489–496. [PubMed] [Google Scholar]
  24. Cohen S. A., Salazar D., von Muenchhausen W., Werner-Wasik M., Nolan J. P. Natural antitumor defense system of the murine liver. J Leukoc Biol. 1985 May;37(5):559–569. doi: 10.1002/jlb.37.5.559. [DOI] [PubMed] [Google Scholar]
  25. Czaja M. J., Weiner F. R., Flanders K. C., Giambrone M. A., Wind R., Biempica L., Zern M. A. In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis. J Cell Biol. 1989 Jun;108(6):2477–2482. doi: 10.1083/jcb.108.6.2477. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Daemen T., Veninga A., Roerdink F. H., Scherphof G. L. In vitro activation of rat liver macrophages to tumoricidal activity by free or liposome-encapsulated muramyl dipeptide. Cancer Res. 1986 Sep;46(9):4330–4335. [PubMed] [Google Scholar]
  27. David H., Kässner G., Krause W., Behrisch D., Wenzel K. W. Ultrastructure and quantitative composition of isolated endothelial cells of rat liver. Exp Pathol. 1990;39(2):95–101. doi: 10.1016/s0232-1513(11)80166-0. [DOI] [PubMed] [Google Scholar]
  28. Davis B. H. Transforming growth factor beta responsiveness is modulated by the extracellular collagen matrix during hepatic ito cell culture. J Cell Physiol. 1988 Sep;136(3):547–553. doi: 10.1002/jcp.1041360323. [DOI] [PubMed] [Google Scholar]
  29. Decker K. Biologically active products of stimulated liver macrophages (Kupffer cells). Eur J Biochem. 1990 Sep 11;192(2):245–261. doi: 10.1111/j.1432-1033.1990.tb19222.x. [DOI] [PubMed] [Google Scholar]
  30. Decker T., Kiderlen A. F., Lohmann-Matthes M. L. Liver macrophages (Kupffer cells) as cytotoxic effector cells in extracellular and intracellular cytotoxicity. Infect Immun. 1985 Nov;50(2):358–364. doi: 10.1128/iai.50.2.358-364.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Dieter P., Schulze-Specking A., Decker K. Ca2+ requirement of prostanoid but not of superoxide production by rat Kupffer cells. Eur J Biochem. 1988 Oct 15;177(1):61–67. doi: 10.1111/j.1432-1033.1988.tb14345.x. [DOI] [PubMed] [Google Scholar]
  32. Dieter P., Schulze-Specking A., Decker K. Differential inhibition of prostaglandin and superoxide production by dexamethasone in primary cultures of rat Kupffer cells. Eur J Biochem. 1986 Sep 15;159(3):451–457. doi: 10.1111/j.1432-1033.1986.tb09907.x. [DOI] [PubMed] [Google Scholar]
  33. Dieter P., Schulze-Specking A., Karck U., Decker K. Prostaglandin release but not superoxide production by rat Kupffer cells stimulated in vitro depends on Na+/H+ exchange. Eur J Biochem. 1987 Dec 30;170(1-2):201–206. doi: 10.1111/j.1432-1033.1987.tb13687.x. [DOI] [PubMed] [Google Scholar]
  34. Dransfield I., Buckle A. M., Hogg N. Early events of the immune response mediated by leukocyte integrins. Immunol Rev. 1990 Apr;114:29–44. doi: 10.1111/j.1600-065x.1990.tb00560.x. [DOI] [PubMed] [Google Scholar]
  35. Eyhorn S., Schlayer H. J., Henninger H. P., Dieter P., Hermann R., Woort-Menker M., Becker H., Schaefer H. E., Decker K. Rat hepatic sinusoidal endothelial cells in monolayer culture. Biochemical and ultrastructural characteristics. J Hepatol. 1988 Feb;6(1):23–35. doi: 10.1016/s0168-8278(88)80459-8. [DOI] [PubMed] [Google Scholar]
  36. Fidler I. J., Schroit A. J. Recognition and destruction of neoplastic cells by activated macrophages: discrimination of altered self. Biochim Biophys Acta. 1988 Nov 15;948(2):151–173. doi: 10.1016/0304-419x(88)90009-1. [DOI] [PubMed] [Google Scholar]
  37. Fraser R., Bosanquet A. G., Day W. A. Filtration of chylomicrons by the liver may influence cholesterol metabolism and atherosclerosis. Atherosclerosis. 1978 Feb;29(2):113–123. doi: 10.1016/0021-9150(78)90001-1. [DOI] [PubMed] [Google Scholar]
  38. Fraser R., Clark S. A., Day W. A., Murray F. E. Nicotine decreases the porosity of the rat liver sieve: a possible mechanism for hypercholesterolaemia. Br J Exp Pathol. 1988 Jun;69(3):345–350. [PMC free article] [PubMed] [Google Scholar]
  39. Fraser R., Heslop V. R., Murray F. E., Day W. A. Ultrastructural studies of the portal transport of fat in chickens. Br J Exp Pathol. 1986 Dec;67(6):783–791. [PMC free article] [PubMed] [Google Scholar]
  40. Freudenberg M. A., Galanos C. Bacterial lipopolysaccharides: structure, metabolism and mechanisms of action. Int Rev Immunol. 1990;6(4):207–221. doi: 10.3109/08830189009056632. [DOI] [PubMed] [Google Scholar]
  41. Funck-Brentano C., Tinel M., Degott C., Letteron P., Babany G., Pessayre D. Protective effect of 16,16-dimethyl prostaglandin E2 on the hepatotoxicity of bromobenzene in mice. Biochem Pharmacol. 1984 Jan 1;33(1):89–96. doi: 10.1016/0006-2952(84)90374-5. [DOI] [PubMed] [Google Scholar]
  42. Geerts A., Greenwel P., Cunningham M., De Bleser P., Rogiers V., Wisse E., Rojkind M. Identification of connective tissue gene transcripts in freshly isolated parenchymal, endothelial, Kupffer and fat-storing cells by northern hybridization analysis. J Hepatol. 1993 Aug;19(1):148–158. doi: 10.1016/s0168-8278(05)80188-6. [DOI] [PubMed] [Google Scholar]
  43. Harrison R. L., Boudreau R. Human hepatic sinusoidal endothelial cells in culture produce von Willebrand factor and contain Weibel-Palade bodies. Liver. 1989 Aug;9(4):242–249. doi: 10.1111/j.1600-0676.1989.tb00406.x. [DOI] [PubMed] [Google Scholar]
  44. Hart I. R., Fidler I. J. Role of organ selectivity in the determination of metastatic patterns of B16 melanoma. Cancer Res. 1980 Jul;40(7):2281–2287. [PubMed] [Google Scholar]
  45. Hellman L., Smedsröd B., Sandberg H., Pettersson U. Secretion of coagulant factor VIII activity and antigen by in vitro cultivated rat liver sinusoidal endothelial cells. Br J Haematol. 1989 Nov;73(3):348–355. doi: 10.1111/j.1365-2141.1989.tb07751.x. [DOI] [PubMed] [Google Scholar]
  46. Horn T., Christoffersen P., Henriksen J. H. Alcoholic liver injury: defenestration in noncirrhotic livers--a scanning electron microscopic study. Hepatology. 1987 Jan-Feb;7(1):77–82. doi: 10.1002/hep.1840070117. [DOI] [PubMed] [Google Scholar]
  47. Horn T., Junge J., Christoffersen P. Early alcoholic liver injury: changes of the Disse space in acinar zone 3. Liver. 1985 Dec;5(6):301–310. doi: 10.1111/j.1600-0676.1985.tb00253.x. [DOI] [PubMed] [Google Scholar]
  48. Irving M. G., Roll F. J., Huang S., Bissell D. M. Characterization and culture of sinusoidal endothelium from normal rat liver: lipoprotein uptake and collagen phenotype. Gastroenterology. 1984 Dec;87(6):1233–1247. [PubMed] [Google Scholar]
  49. Jacob A. I., Goldberg P. K., Bloom N., Degenshein G. A., Kozinn P. J. Endotoxin and bacteria in portal blood. Gastroenterology. 1977 Jun;72(6):1268–1270. [PubMed] [Google Scholar]
  50. Jaffe E. A., Nachman R. L., Becker C. G., Minick C. R. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest. 1973 Nov;52(11):2745–2756. doi: 10.1172/JCI107470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Karck U., Peters T., Decker K. The release of tumor necrosis factor from endotoxin-stimulated rat Kupffer cells is regulated by prostaglandin E2 and dexamethasone. J Hepatol. 1988 Dec;7(3):352–361. doi: 10.1016/s0168-8278(88)80008-4. [DOI] [PubMed] [Google Scholar]
  52. Kelly D. A., Summerfield J. A., Tuddenham E. G. Localization of factor VIIIC: antigen in guinea-pig tissues and isolated liver cell fractions. Br J Haematol. 1984 Apr;56(4):535–543. doi: 10.1111/j.1365-2141.1984.tb02178.x. [DOI] [PubMed] [Google Scholar]
  53. Keppler D., Huber M., Baumert T. Leukotrienes as mediators in diseases of the liver. Semin Liver Dis. 1988 Nov;8(4):357–366. doi: 10.1055/s-2008-1040557. [DOI] [PubMed] [Google Scholar]
  54. Kindberg G. M., Magnusson S., Berg T., Smedsrød B. Receptor-mediated endocytosis of ovalbumin by two carbohydrate-specific receptors in rat liver cells. The intracellular transport of ovalbumin to lysosomes is faster in liver endothelial cells than in parenchymal cells. Biochem J. 1990 Aug 15;270(1):197–203. doi: 10.1042/bj2700197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Kindberg G. M., Stang E., Andersen K. J., Roos N., Berg T. Intracellular transport of endocytosed proteins in rat liver endothelial cells. Biochem J. 1990 Aug 15;270(1):205–211. doi: 10.1042/bj2700205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Knook D. L., Sleyster E. C. Separation of Kupffer and endothelial cells of the rat liver by centrifugal elutriation. Exp Cell Res. 1976 May;99(2):444–449. doi: 10.1016/0014-4827(76)90605-4. [DOI] [PubMed] [Google Scholar]
  57. Krause H., Dieter P., Schulze-Specking A., Ballhorn A., Ferber E., Decker K. Synergistic effect of magnesium and calcium ions in the activation of phospholipase A2 of liver macrophages. Biochem Biophys Res Commun. 1991 Mar 15;175(2):532–536. doi: 10.1016/0006-291x(91)91597-6. [DOI] [PubMed] [Google Scholar]
  58. Kunkel S. L., Chensue S. W., Phan S. H. Prostaglandins as endogenous mediators of interleukin 1 production. J Immunol. 1986 Jan;136(1):186–192. [PubMed] [Google Scholar]
  59. Lapis K., Jeney A., Divald A., Vajta G., Zalatnai A., Schaff Z. Experimental studies on the effect of hepatoprotective compounds. Tokai J Exp Clin Med. 1986;11 (Suppl):135–145. [PubMed] [Google Scholar]
  60. Larson R. S., Springer T. A. Structure and function of leukocyte integrins. Immunol Rev. 1990 Apr;114:181–217. doi: 10.1111/j.1600-065x.1990.tb00565.x. [DOI] [PubMed] [Google Scholar]
  61. Libby P., Warner S. J., Friedman G. B. Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids. J Clin Invest. 1988 Feb;81(2):487–498. doi: 10.1172/JCI113346. [DOI] [PMC free article] [PubMed] [Google Scholar]
  62. Litwin J. A. Peroxidase-positive endothelial cells in rat liver. Cell Tissue Res. 1984;238(3):635–642. doi: 10.1007/BF00219882. [DOI] [PubMed] [Google Scholar]
  63. Magnusson S., Berg T. Extremely rapid endocytosis mediated by the mannose receptor of sinusoidal endothelial rat liver cells. Biochem J. 1989 Feb 1;257(3):651–656. doi: 10.1042/bj2570651. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Maher J. J., McGuire R. F. Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo. J Clin Invest. 1990 Nov;86(5):1641–1648. doi: 10.1172/JCI114886. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Malter M., Friedrich E., Süss R. Liver as a tumor cell killing organ: Kupffer cells and natural killers. Cancer Res. 1986 Jun;46(6):3055–3060. [PubMed] [Google Scholar]
  66. Mantovani A., Dejana E. Cytokines as communication signals between leukocytes and endothelial cells. Immunol Today. 1989 Nov;10(11):370–375. doi: 10.1016/0167-5699(89)90270-3. [DOI] [PubMed] [Google Scholar]
  67. Marlin S. D., Springer T. A. Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell. 1987 Dec 4;51(5):813–819. doi: 10.1016/0092-8674(87)90104-8. [DOI] [PubMed] [Google Scholar]
  68. Massagué J. The transforming growth factor-beta family. Annu Rev Cell Biol. 1990;6:597–641. doi: 10.1146/annurev.cb.06.110190.003121. [DOI] [PubMed] [Google Scholar]
  69. Matsuoka M., Pham N. T., Tsukamoto H. Differential effects of interleukin-1 alpha, tumor necrosis factor alpha, and transforming growth factor beta 1 on cell proliferation and collagen formation by cultured fat-storing cells. Liver. 1989 Apr;9(2):71–78. doi: 10.1111/j.1600-0676.1989.tb00382.x. [DOI] [PubMed] [Google Scholar]
  70. Matsuoka M., Tsukamoto H. Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor beta: implication for a pathogenetic role in alcoholic liver fibrogenesis. Hepatology. 1990 Apr;11(4):599–605. doi: 10.1002/hep.1840110412. [DOI] [PubMed] [Google Scholar]
  71. McGuire R. F., Bissell D. M., Boyles J., Roll F. J. Role of extracellular matrix in regulating fenestrations of sinusoidal endothelial cells isolated from normal rat liver. Hepatology. 1992 Jun;15(6):989–997. doi: 10.1002/hep.1840150603. [DOI] [PubMed] [Google Scholar]
  72. Melkko J., Hellevik T., Risteli L., Risteli J., Smedsrød B. Clearance of NH2-terminal propeptides of types I and III procollagen is a physiological function of the scavenger receptor in liver endothelial cells. J Exp Med. 1994 Feb 1;179(2):405–412. doi: 10.1084/jem.179.2.405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  73. Misquith S., Wattiaux-De Coninck S., Wattiaux R. Uptake and intracellular transport in rat liver of formaldehyde-treated bovine serum albumin labelled with 125I-tyramine-cellobiose. Eur J Biochem. 1988 Jul 1;174(4):691–697. doi: 10.1111/j.1432-1033.1988.tb14153.x. [DOI] [PubMed] [Google Scholar]
  74. Moncada S., Higgs E. A., Vane J. R. Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation. Lancet. 1977 Jan 1;1(8001):18–20. doi: 10.1016/s0140-6736(77)91655-5. [DOI] [PubMed] [Google Scholar]
  75. Mori T., Okanoue T., Sawa Y., Hori N., Ohta M., Kagawa K. Defenestration of the sinusoidal endothelial cell in a rat model of cirrhosis. Hepatology. 1993 May;17(5):891–897. [PubMed] [Google Scholar]
  76. Murphy G. P. Management of metastatic prostatic cancer. Prog Clin Biol Res. 1988;277:127–134. [PubMed] [Google Scholar]
  77. Männel D. N., Meltzer M. S., Mergenhagen S. E. Generation and characterization of a lipopolysaccharide-induced and serum-derived cytotoxic factor for tumor cells. Infect Immun. 1980 Apr;28(1):204–211. doi: 10.1128/iai.28.1.204-211.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  78. Nagelkerke J. F., Barto K. P., van Berkel T. J. In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells. J Biol Chem. 1983 Oct 25;258(20):12221–12227. [PubMed] [Google Scholar]
  79. Naito M., Wisse E. Filtration effect of endothelial fenestrations on chylomicron transport in neonatal rat liver sinusoids. Cell Tissue Res. 1978 Jul 10;190(3):371–382. doi: 10.1007/BF00219553. [DOI] [PubMed] [Google Scholar]
  80. Naito S., von Eschenbach A. C., Fidler I. J. Different growth pattern and biologic behavior of human renal cell carcinoma implanted into different organs of nude mice. J Natl Cancer Inst. 1987 Feb;78(2):377–385. [PubMed] [Google Scholar]
  81. Nicolson G. L. Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites. Cancer Metastasis Rev. 1988 Jun;7(2):143–188. doi: 10.1007/BF00046483. [DOI] [PubMed] [Google Scholar]
  82. Nicolson G. L., Poste G. Tumor cell diversity and host responses in cancer metastasis--part I--properties of metastatic cells. Curr Probl Cancer. 1982 Dec;7(6):1–83. doi: 10.1016/s0147-0272(82)80017-2. [DOI] [PubMed] [Google Scholar]
  83. Onda M., Toba M., Andoh T., Shirota A. Ultrastructural studies of experimental endotoxin shock in the liver and spleen: therapeutic effects of low-dose heparin on reticuloendothelial disturbances. Circ Shock. 1986;18(1):11–19. [PubMed] [Google Scholar]
  84. Osborn L., Hession C., Tizard R., Vassallo C., Luhowskyj S., Chi-Rosso G., Lobb R. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell. 1989 Dec 22;59(6):1203–1211. doi: 10.1016/0092-8674(89)90775-7. [DOI] [PubMed] [Google Scholar]
  85. Petrovic L. M., Burroughs A., Scheuer P. J. Hepatic sinusoidal endothelium: Ulex lectin binding. Histopathology. 1989 Mar;14(3):233–243. doi: 10.1111/j.1365-2559.1989.tb02142.x. [DOI] [PubMed] [Google Scholar]
  86. Phillips N. C. Kupffer cells and liver metastasis. Optimization and limitation of activation of tumoricidal activity. Cancer Metastasis Rev. 1989 Dec;8(3):231–252. doi: 10.1007/BF00047339. [DOI] [PubMed] [Google Scholar]
  87. Pitas R. E., Boyles J., Mahley R. W., Bissell D. M. Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells. J Cell Biol. 1985 Jan;100(1):103–117. doi: 10.1083/jcb.100.1.103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  88. Prytz H., Holst-Christensen J., Korner B., Liehr H. Portal venous and systemic endotoxaemia in patients without liver disease and systemic endotoxaemia in patients with cirrhosis. Scand J Gastroenterol. 1976;11(8):857–863. [PubMed] [Google Scholar]
  89. Rice G. E., Bevilacqua M. P. An inducible endothelial cell surface glycoprotein mediates melanoma adhesion. Science. 1989 Dec 8;246(4935):1303–1306. doi: 10.1126/science.2588007. [DOI] [PubMed] [Google Scholar]
  90. Rieder H., Ramadori G., Allmann K. H., Meyer zum Büschenfelde K. H. Prostanoid release of cultured liver sinusoidal endothelial cells in response to endotoxin and tumor necrosis factor. Comparison with umbilical vein endothelial cells. J Hepatol. 1990 Nov;11(3):359–366. doi: 10.1016/0168-8278(90)90222-d. [DOI] [PubMed] [Google Scholar]
  91. Rieder H., Ramadori G., Dienes H. P., Meyer zum Büschenfelde K. H. Sinusoidal endothelial cells from guinea pig liver synthesize and secrete cellular fibronectin in vitro. Hepatology. 1987 Sep-Oct;7(5):856–864. doi: 10.1002/hep.1840070511. [DOI] [PubMed] [Google Scholar]
  92. Rogers G. W., Dobbs B. R., Fraser R. Decreased hepatic uptake of cholesterol and retinol in the dimethylnitrosamine rat model of cirrhosis. Liver. 1992 Oct;12(5):326–329. doi: 10.1111/j.1600-0676.1992.tb00581.x. [DOI] [PubMed] [Google Scholar]
  93. Roh M. S., Wang L., Oyedeji C., LeRoux M. E., Curley S. A., Pollock R. E., Klostergaard J. Human Kupffer cells are cytotoxic against human colon adenocarcinoma. Surgery. 1990 Aug;108(2):400–405. doi: 10.1002/bjs.1800770937. [DOI] [PubMed] [Google Scholar]
  94. Roos E., Middelkoop O. P., Van de Pavert I. V. Adhesion of tumor cells to hepatocytes: different mechanisms for mammary carcinoma compared with lymphosarcoma cells. J Natl Cancer Inst. 1984 Oct;73(4):963–969. [PubMed] [Google Scholar]
  95. Rush B. D., Wilkinson K. F., Nichols N. M., Ochoa R., Brunden M. N., Ruwart M. J. Hepatic protection by 16, 16-dimethyl prostaglandin E2 (DMPG) against acute aflatoxin B1-induced injury in the rat. Prostaglandins. 1989 Jun;37(6):683–693. doi: 10.1016/0090-6980(89)90105-6. [DOI] [PubMed] [Google Scholar]
  96. Schirrmacher V. Cancer metastasis: experimental approaches, theoretical concepts, and impacts for treatment strategies. Adv Cancer Res. 1985;43:1–73. doi: 10.1016/s0065-230x(08)60942-2. [DOI] [PubMed] [Google Scholar]
  97. Schlayer H. J., Karck U., Ganter U., Hermann R., Decker K. Enhancement of neutrophil adherence to isolated rat liver sinusoidal endothelial cells by supernatants of lipopolysaccharide-activated monocytes. Role of tumor necrosis factor. J Hepatol. 1987 Dec;5(3):311–321. doi: 10.1016/s0168-8278(87)80037-5. [DOI] [PubMed] [Google Scholar]
  98. Schlayer H. J., Laaff H., Peters T., Woort-Menker M., Estler H. C., Karck U., Schaefer H. E., Decker K. Involvement of tumor necrosis factor in endotoxin-triggered neutrophil adherence to sinusoidal endothelial cells of mouse liver and its modulation in acute phase. J Hepatol. 1988 Oct;7(2):239–249. doi: 10.1016/s0168-8278(88)80488-4. [DOI] [PubMed] [Google Scholar]
  99. Shaw R. G., Johnson A. R., Schulz W. W., Zahlten R. N., Combes B. Sinusoidal endothelial cells from normal guinea pig liver: isolation, culture and characterization. Hepatology. 1984 Jul-Aug;4(4):591–602. doi: 10.1002/hep.1840040403. [DOI] [PubMed] [Google Scholar]
  100. Sikujara O., Monden M., Toyoshima K., Okamura J., Kosaki G. Cytoprotective effect of prostaglandin I2 on ischemia-induced hepatic cell injury. Transplantation. 1983 Sep;36(3):238–243. doi: 10.1097/00007890-198309000-00002. [DOI] [PubMed] [Google Scholar]
  101. Sinclair S. B., Greig P. D., Blendis L. M., Abecassis M., Roberts E. A., Phillips M. J., Cameron R., Levy G. A. Biochemical and clinical response of fulminant viral hepatitis to administration of prostaglandin E. A preliminary report. J Clin Invest. 1989 Oct;84(4):1063–1069. doi: 10.1172/JCI114268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  102. Smedsrød B., Johansson S., Pertoft H. Studies in vivo and in vitro on the uptake and degradation of soluble collagen alpha 1(I) chains in rat liver endothelial and Kupffer cells. Biochem J. 1985 Jun 1;228(2):415–424. doi: 10.1042/bj2280415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  103. Smedsrød B., Kjellén L., Pertoft H. Endocytosis and degradation of chondroitin sulphate by liver endothelial cells. Biochem J. 1985 Jul 1;229(1):63–71. doi: 10.1042/bj2290063. [DOI] [PMC free article] [PubMed] [Google Scholar]
  104. Smedsrød B., Malmgren M., Ericsson J., Laurent T. C. Morphological studies on endocytosis of chondroitin sulphate proteoglycan by rat liver endothelial cells. Cell Tissue Res. 1988 Jul;253(1):39–45. doi: 10.1007/BF00221737. [DOI] [PubMed] [Google Scholar]
  105. Smedsrød B., Melkko J., Risteli L., Risteli J. Circulating C-terminal propeptide of type I procollagen is cleared mainly via the mannose receptor in liver endothelial cells. Biochem J. 1990 Oct 15;271(2):345–350. doi: 10.1042/bj2710345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  106. Smedsrød B., Paulsson M., Johansson S. Uptake and degradation in vivo and in vitro of laminin and nidogen by rat liver cells. Biochem J. 1989 Jul 1;261(1):37–42. doi: 10.1042/bj2610037. [DOI] [PMC free article] [PubMed] [Google Scholar]
  107. Smedsrød B., Pertoft H., Gustafson S., Laurent T. C. Scavenger functions of the liver endothelial cell. Biochem J. 1990 Mar 1;266(2):313–327. doi: 10.1042/bj2660313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  108. Smedsrød B., Pertoft H. Preparation of pure hepatocytes and reticuloendothelial cells in high yield from a single rat liver by means of Percoll centrifugation and selective adherence. J Leukoc Biol. 1985 Aug;38(2):213–230. doi: 10.1002/jlb.38.2.213. [DOI] [PubMed] [Google Scholar]
  109. Sporn M. B., Roberts A. B., Wakefield L. M., de Crombrugghe B. Some recent advances in the chemistry and biology of transforming growth factor-beta. J Cell Biol. 1987 Sep;105(3):1039–1045. doi: 10.1083/jcb.105.3.1039. [DOI] [PMC free article] [PubMed] [Google Scholar]
  110. Stang E., Kindberg G. M., Berg T., Roos N. Endocytosis mediated by the mannose receptor in liver endothelial cells. An immunocytochemical study. Eur J Cell Biol. 1990 Jun;52(1):67–76. [PubMed] [Google Scholar]
  111. Staunton D. E., Dustin M. L., Springer T. A. Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1. Nature. 1989 May 4;339(6219):61–64. doi: 10.1038/339061a0. [DOI] [PubMed] [Google Scholar]
  112. Steffan A. M., Gendrault J. L., Kirn A. Increase in the number of fenestrae in mouse endothelial liver cells by altering the cytoskeleton with cytochalasin B. Hepatology. 1987 Nov-Dec;7(6):1230–1238. doi: 10.1002/hep.1840070610. [DOI] [PubMed] [Google Scholar]
  113. Stein O., Stein Y. Bovine aortic endothelial cells display macrophage-like properties towards acetylated 125I-labelled low density lipoprotein. Biochim Biophys Acta. 1980 Dec 5;620(3):631–635. doi: 10.1016/0005-2760(80)90155-1. [DOI] [PubMed] [Google Scholar]
  114. Stel H. V., van der Kwast T. H., Veerman E. C. Detection of factor VIII/coagulant antigen in human liver tissue. Nature. 1983 Jun 9;303(5917):530–532. doi: 10.1038/303530a0. [DOI] [PubMed] [Google Scholar]
  115. Stoolman L. M., Kaldjian E. Adhesion molecules involved in the trafficking of normal and malignant leukocytes. Invasion Metastasis. 1992;12(2):101–111. [PubMed] [Google Scholar]
  116. Stöhr G., Deimann W., Fahimi H. D. Peroxidase-positive endothelial cells in sinusoids of the mouse liver. J Histochem Cytochem. 1978 May;26(5):409–411. doi: 10.1177/26.5.659841. [DOI] [PubMed] [Google Scholar]
  117. Tate G. A., Mandell B. F., Schumacher H. R., Jr, Zurier R. B. Suppression of acute inflammation by 15 methyl prostaglandin E1. Lab Invest. 1988 Aug;59(2):192–199. [PubMed] [Google Scholar]
  118. Terada T., Nakanuma Y. Expression of ABH blood group antigens, Ulex europaeus agglutinin I, and type IV collagen in the sinusoids of hepatocellular carcinoma. Arch Pathol Lab Med. 1991 Jan;115(1):50–55. [PubMed] [Google Scholar]
  119. Tressler R. J., Belloni P. N., Nicolson G. L. Correlation of inhibition of adhesion of large cell lymphoma and hepatic sinusoidal endothelial cells by RGD-containing peptide polymers with metastatic potential: role of integrin-dependent and -independent adhesion mechanisms. Cancer Commun. 1989;1(1):55–63. doi: 10.3727/095535489820875417. [DOI] [PubMed] [Google Scholar]
  120. Tsutsumi Y., Kakumu S., Yoshioka K., Arao M., Inoue M., Wakita T. Effects of various cytokines on collagen synthesis by normal rat hepatocytes in primary cultures and fibroblasts. Digestion. 1989;44(4):191–199. doi: 10.1159/000199911. [DOI] [PubMed] [Google Scholar]
  121. Van Berkel T. J., De Rijke Y. B., Kruijt J. K. Different fate in vivo of oxidatively modified low density lipoprotein and acetylated low density lipoprotein in rats. Recognition by various scavenger receptors on Kupffer and endothelial liver cells. J Biol Chem. 1991 Feb 5;266(4):2282–2289. [PubMed] [Google Scholar]
  122. Wake K., Decker K., Kirn A., Knook D. L., McCuskey R. S., Bouwens L., Wisse E. Cell biology and kinetics of Kupffer cells in the liver. Int Rev Cytol. 1989;118:173–229. doi: 10.1016/s0074-7696(08)60875-x. [DOI] [PubMed] [Google Scholar]
  123. Wakefield L. M., Smith D. M., Masui T., Harris C. C., Sporn M. B. Distribution and modulation of the cellular receptor for transforming growth factor-beta. J Cell Biol. 1987 Aug;105(2):965–975. doi: 10.1083/jcb.105.2.965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  124. Weiner F. R., Shah A., Biempica L., Zern M. A., Czaja M. J. The effects of hepatic fibrosis on Ito cell gene expression. Matrix. 1992 Feb;12(1):36–43. doi: 10.1016/s0934-8832(11)80102-2. [DOI] [PubMed] [Google Scholar]
  125. Weiss L. Random and nonrandom processes in metastasis, and metastatic inefficiency. Invasion Metastasis. 1983;3(4):193–207. [PubMed] [Google Scholar]
  126. Wisse E. An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoids. J Ultrastruct Res. 1970 Apr;31(1):125–150. doi: 10.1016/s0022-5320(70)90150-4. [DOI] [PubMed] [Google Scholar]
  127. Wisse E. An ultrastructural characterization of the endothelial cell in the rat liver sinusoid under normal and various experimental conditions, as a contribution to the distinction between endothelial and Kupffer cells. J Ultrastruct Res. 1972 Mar;38(5):528–562. doi: 10.1016/0022-5320(72)90089-5. [DOI] [PubMed] [Google Scholar]
  128. Wisse E., De Zanger R. B., Charels K., Van Der Smissen P., McCuskey R. S. The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse. Hepatology. 1985 Jul-Aug;5(4):683–692. doi: 10.1002/hep.1840050427. [DOI] [PubMed] [Google Scholar]
  129. Wisse E. Kupffer cell reactions in rat liver under various conditions as observed in the electron microscope. J Ultrastruct Res. 1974 Mar;46(3):499–520. doi: 10.1016/s0022-5320(74)90070-7. [DOI] [PubMed] [Google Scholar]
  130. Wisse E. Observations on the fine structure and peroxidase cytochemistry of normal rat liver Kupffer cells. J Ultrastruct Res. 1974 Mar;46(3):393–426. doi: 10.1016/s0022-5320(74)90064-1. [DOI] [PubMed] [Google Scholar]
  131. Wright P. L., Smith K. F., Day W. A., Fraser R. Small liver fenestrae may explain the susceptibility of rabbits to atherosclerosis. Arteriosclerosis. 1983 Jul-Aug;3(4):344–348. doi: 10.1161/01.atv.3.4.344. [DOI] [PubMed] [Google Scholar]
  132. Zelechowska M. G., van Mourik J. A., Brodniewicz-Proba T. Ultrastructural localization of factor VIII procoagulant antigen in human liver hepatocytes. Nature. 1985 Oct 24;317(6039):729–730. doi: 10.1038/317729a0. [DOI] [PubMed] [Google Scholar]

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