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. 1994 Sep;35(9):1267–1270. doi: 10.1136/gut.35.9.1267

Comparison of gastrointestinal symptoms in colorectal carcinoma patients and community controls with respect to age.

R Curless 1, J French 1, G V Williams 1, O F James 1
PMCID: PMC1375705  PMID: 7959235

Abstract

Early diagnosis of colorectal cancer may be delayed by the wide prevalence of gastrointestinal symptoms in the general population. This study assessed, with respect to age, the frequency of gastro-intestinal symptoms in patients with colorectal carcinoma in comparison with community controls and also compared the frequency of such symptoms between 'young' (under 70 years) and 'old' (70 year or over) subjects. Two hundred and seventy three consecutive unselected colorectal cancer patients and 273 age and sex matched community controls were interviewed in a structured manner. Among controls, the 'old' group compared with the 'young' reported abdominal pain (p < 0.05), mucous discharge (p < 0.01), faecal incontinence (p < 0.05), change in flatus production (p < 0.05) significantly more often. There were no significant differences in regularity and frequency of bowel habit by age group. All the symptoms considered were significantly more common in colorectal cancer cases than controls (except abdominal bloating), but the association was less strong in the 'old' group. This study confirms that symptoms attributable to the lower gastrointestinal tract are reported by a clinically important number of community subjects and by a significantly higher proportion of elderly people.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barbara L., Camilleri M., Corinaldesi R., Crean G. P., Heading R. C., Johnson A. G., Malagelada J. R., Stanghellini V., Wienbeck M. Definition and investigation of dyspepsia. Consensus of an international ad hoc working party. Dig Dis Sci. 1989 Aug;34(8):1272–1276. doi: 10.1007/BF01537277. [DOI] [PubMed] [Google Scholar]
  2. Campbell A. J., Busby W. J., Horwath C. C. Factors associated with constipation in a community based sample of people aged 70 years and over. J Epidemiol Community Health. 1993 Feb;47(1):23–26. doi: 10.1136/jech.47.1.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Connell A. M., Hilton C., Irvine G., Lennard-Jones J. E., Misiewicz J. J. Variation of bowel habit in two population samples. Br Med J. 1965 Nov 6;2(5470):1095–1099. doi: 10.1136/bmj.2.5470.1095. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dixon A. R., Thornton-Holmes J., Cheetham N. M. General practitioners' awareness of colorectal cancer: a 10 year review. BMJ. 1990 Jul 21;301(6744):152–153. doi: 10.1136/bmj.301.6744.152. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Donald I. P., Smith R. G., Cruikshank J. G., Elton R. A., Stoddart M. E. A study of constipation in the elderly living at home. Gerontology. 1985;31(2):112–118. doi: 10.1159/000212689. [DOI] [PubMed] [Google Scholar]
  6. Edwards R. T., Bransom C. J., Crosby D. L., Pathy M. S. Colorectal carcinoma in the elderly: a geriatric and surgical practice compared. Age Ageing. 1983 Aug;12(3):256–262. doi: 10.1093/ageing/12.3.256. [DOI] [PubMed] [Google Scholar]
  7. Everhart J. E., Go V. L., Johannes R. S., Fitzsimmons S. C., Roth H. P., White L. R. A longitudinal survey of self-reported bowel habits in the United States. Dig Dis Sci. 1989 Aug;34(8):1153–1162. doi: 10.1007/BF01537261. [DOI] [PubMed] [Google Scholar]
  8. Hale W. E., Perkins L. L., May F. E., Marks R. G., Stewart R. B. Symptom prevalence in the elderly. An evaluation of age, sex, disease, and medication use. J Am Geriatr Soc. 1986 May;34(5):333–340. doi: 10.1111/j.1532-5415.1986.tb04315.x. [DOI] [PubMed] [Google Scholar]
  9. Heaton K. W., O'Donnell L. J., Braddon F. E., Mountford R. A., Hughes A. O., Cripps P. J. Symptoms of irritable bowel syndrome in a British urban community: consulters and nonconsulters. Gastroenterology. 1992 Jun;102(6):1962–1967. doi: 10.1016/0016-5085(92)90320-x. [DOI] [PubMed] [Google Scholar]
  10. Heaton K. W., Radvan J., Cripps H., Mountford R. A., Braddon F. E., Hughes A. O. Defecation frequency and timing, and stool form in the general population: a prospective study. Gut. 1992 Jun;33(6):818–824. doi: 10.1136/gut.33.6.818. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Holliday H. W., Hardcastle J. D. Delay in diagnosis and treatment of symptomatic colorectal cancer. Lancet. 1979 Feb 10;1(8111):309–311. doi: 10.1016/s0140-6736(79)90718-9. [DOI] [PubMed] [Google Scholar]
  12. Jones R., Lydeard S. Irritable bowel syndrome in the general population. BMJ. 1992 Jan 11;304(6819):87–90. doi: 10.1136/bmj.304.6819.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Jones R., Lydeard S. Prevalence of symptoms of dyspepsia in the community. BMJ. 1989 Jan 7;298(6665):30–32. doi: 10.1136/bmj.298.6665.30. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kay L., Jørgensen T., Schultz-Larsen K. Abdominal pain in a 70-year-old Danish population. An epidemiological study of the prevalence and importance of abdominal pain. J Clin Epidemiol. 1992 Dec;45(12):1377–1382. doi: 10.1016/0895-4356(92)90199-w. [DOI] [PubMed] [Google Scholar]
  15. Kemppainen M., Räihä I., Rajala T., Sourander L. Delay in diagnosis of colorectal cancer in elderly patients. Age Ageing. 1993 Jul;22(4):260–264. doi: 10.1093/ageing/22.4.260. [DOI] [PubMed] [Google Scholar]
  16. MacDonald L., Freeling P. Bowels: beliefs and behaviour. Fam Pract. 1986 Jun;3(2):80–84. doi: 10.1093/fampra/3.2.80. [DOI] [PubMed] [Google Scholar]
  17. Manning A. P., Thompson W. G., Heaton K. W., Morris A. F. Towards positive diagnosis of the irritable bowel. Br Med J. 1978 Sep 2;2(6138):653–654. doi: 10.1136/bmj.2.6138.653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Manning A. P., Wyman J. B., Heaton K. W. How trustworthy are bowel histories? Comparison of recalled and recorded information. Br Med J. 1976 Jul 24;2(6029):213–214. doi: 10.1136/bmj.2.6029.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Milne J. S., Williamson J. Bowel habit in older people. Gerontol Clin (Basel) 1972;14(1):56–60. doi: 10.1159/000245372. [DOI] [PubMed] [Google Scholar]
  20. Moore-Gillon V. Constipation: what does the patient mean? J R Soc Med. 1984 Feb;77(2):108–110. doi: 10.1177/014107688407700207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Robinson E., Mohilever J., Zidan J., Sapir D. Colorectal cancer: incidence, delay in diagnosis and stage of disease. Eur J Cancer Clin Oncol. 1986 Feb;22(2):157–161. doi: 10.1016/0277-5379(86)90025-8. [DOI] [PubMed] [Google Scholar]
  22. Sandercock P. The odds ratio: a useful tool in neurosciences. J Neurol Neurosurg Psychiatry. 1989 Jul;52(7):817–820. doi: 10.1136/jnnp.52.7.817. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Sandler R. S., Jordan M. C., Shelton B. J. Demographic and dietary determinants of constipation in the US population. Am J Public Health. 1990 Feb;80(2):185–189. doi: 10.2105/ajph.80.2.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Sonnenberg A., Koch T. R. Epidemiology of constipation in the United States. Dis Colon Rectum. 1989 Jan;32(1):1–8. doi: 10.1007/BF02554713. [DOI] [PubMed] [Google Scholar]
  25. Stower M. J., Hardcastle J. D. The results of 1115 patients with colorectal cancer treated over an 8-year period in a single hospital. Eur J Surg Oncol. 1985 Jun;11(2):119–123. [PubMed] [Google Scholar]
  26. Talley N. J., McNeil D., Piper D. W. Discriminant value of dyspeptic symptoms: a study of the clinical presentation of 221 patients with dyspepsia of unknown cause, peptic ulceration, and cholelithiasis. Gut. 1987 Jan;28(1):40–46. doi: 10.1136/gut.28.1.40. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Talley N. J., Phillips S. F., Melton L. J., Mulvihill C., Wiltgen C., Zinsmeister A. R. Diagnostic value of the Manning criteria in irritable bowel syndrome. Gut. 1990 Jan;31(1):77–81. doi: 10.1136/gut.31.1.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Waldron R. P., Donovan I. A., Drumm J., Mottram S. N., Tedman S. Emergency presentation and mortality from colorectal cancer in the elderly. Br J Surg. 1986 Mar;73(3):214–216. doi: 10.1002/bjs.1800730320. [DOI] [PubMed] [Google Scholar]
  29. Whitehead W. E., Drinkwater D., Cheskin L. J., Heller B. R., Schuster M. M. Constipation in the elderly living at home. Definition, prevalence, and relationship to lifestyle and health status. J Am Geriatr Soc. 1989 May;37(5):423–429. doi: 10.1111/j.1532-5415.1989.tb02638.x. [DOI] [PubMed] [Google Scholar]

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