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. 1991 Jun;17(2):70–76. doi: 10.1136/jme.17.2.70

Fetal tissue transplantation: can it be morally insulated from abortion?

C Strong 1
PMCID: PMC1376000  PMID: 1870085

Abstract

Ethical controversy over transplantation of human fetal tissue has arisen because the source of tissue is induced abortions. Opposition to such transplants has been based on various arguments, including the following: rightful informed consent cannot be obtained for use of fetal tissue from induced abortions, and fetal tissue transplantation might result in an increase in the number of abortions. These arguments were not accepted by the National Institutes of Health (NIH) Human Fetal Tissue Transplantation Research Panel. The majority opinion of the panel stated that abortion and fetal tissue use are entirely separate issues, and that tissue use is ethically acceptable because it can be morally insulated from the issue of abortion. In support of this view, panel members and others have replied to the arguments put forward by opponents of fetal tissue use. However, replies to the two arguments mentioned above have been unsatisfactory, and the shortcomings of those replies are identified herein. Examination of the arguments pro and con suggests that fetal tissue use cannot be completely insulated from the issue of abortion. Thus, in seeking an ethical justification for fetal tissue transplantation we must consider reasons other than those put forward by the NIH panel. In this paper it is argued that whatever wrong is involved in using fetal tissue from induced abortions must be balanced against the benefits for patients, and it is on this basis that fetal tissue transplantation can be ethically justified.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen G. S., Burns R. S., Tulipan N. B., Parker R. A. Adrenal medullary transplantation to the caudate nucleus in Parkinson's disease. Initial clinical results in 18 patients. Arch Neurol. 1989 May;46(5):487–491. doi: 10.1001/archneur.1989.00520410021016. [DOI] [PubMed] [Google Scholar]
  2. Anand K. J., Hickey P. R. Pain and its effects in the human neonate and fetus. N Engl J Med. 1987 Nov 19;317(21):1321–1329. doi: 10.1056/NEJM198711193172105. [DOI] [PubMed] [Google Scholar]
  3. Annas G. J., Elias S. The politics of transplantation of human fetal tissue. N Engl J Med. 1989 Apr 20;320(16):1079–1082. doi: 10.1056/NEJM198904203201610. [DOI] [PubMed] [Google Scholar]
  4. Björklund A., Dunnett S. B., Stenevi U., Lewis M. E., Iversen S. D. Reinnervation of the denervated striatum by substantia nigra transplants: functional consequences as revealed by pharmacological and sensorimotor testing. Brain Res. 1980 Oct 20;199(2):307–333. doi: 10.1016/0006-8993(80)90692-7. [DOI] [PubMed] [Google Scholar]
  5. Björklund A., Stenevi U. Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res. 1979 Nov 30;177(3):555–560. doi: 10.1016/0006-8993(79)90472-4. [DOI] [PubMed] [Google Scholar]
  6. Burtchaell James Tunstead. University policy on experimental use of aborted fetal tissue: case study. IRB. 1988 Jul-Aug;10(4):7–11. [PubMed] [Google Scholar]
  7. Ceroni M., Minoli L., Di Perri G., Senaldi G., Marone P., Achilli G., Mondelli M., Camana C. Detection of HTLV-III-specific IgG bands in the CSF from a patient with AIDS and encephalitis. Neurology. 1988 Jan;38(1):143–144. doi: 10.1212/wnl.38.1.143. [DOI] [PubMed] [Google Scholar]
  8. Freed W. J., Perlow M. J., Karoum F., Seiger A., Olson L., Hoffer B. J., Wyatt R. J. Restoration of dopaminergic function by grafting of fetal rat substantia nigra to the caudate nucleus: long-term behavioral, biochemical, and histochemical studies. Ann Neurol. 1980 Nov;8(5):510–519. doi: 10.1002/ana.410080508. [DOI] [PubMed] [Google Scholar]
  9. Gillon R. Ethics of fetal brain cell transplants. Br Med J (Clin Res Ed) 1988 Apr 30;296(6631):1212–1213. doi: 10.1136/bmj.296.6631.1212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Greely H. T., Hamm T., Johnson R., Price C. R., Weingarten R., Raffin T. The ethical use of human fetal tissue in medicine. Stanford University Medical Center Committee on Ethics. N Engl J Med. 1989 Apr 20;320(16):1093–1096. doi: 10.1056/NEJM198904203201624. [DOI] [PubMed] [Google Scholar]
  11. Hitchcock E. R., Clough C., Hughes R., Kenny B. Embryos and Parkinson's disease. Lancet. 1988 Jun 4;1(8597):1274–1274. doi: 10.1016/s0140-6736(88)92088-0. [DOI] [PubMed] [Google Scholar]
  12. Hoffer B. J., Granholm A. C., Stevens J. O., Olson L. Catecholamine-containing grafts in parkinsonism: past and present. Clin Res. 1988 Apr;36(3):189–195. [PubMed] [Google Scholar]
  13. Joynt R. J., Gash D. M. Neural transplants: are we ready? Ann Neurol. 1987 Oct;22(4):455–456. doi: 10.1002/ana.410220402. [DOI] [PubMed] [Google Scholar]
  14. Lewin R. Caution continues over transplants. Science. 1988 Dec 9;242(4884):1379–1379. doi: 10.1126/science.3207454. [DOI] [PubMed] [Google Scholar]
  15. Lindvall O., Brundin P., Widner H., Rehncrona S., Gustavii B., Frackowiak R., Leenders K. L., Sawle G., Rothwell J. C., Marsden C. D. Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. Science. 1990 Feb 2;247(4942):574–577. doi: 10.1126/science.2105529. [DOI] [PubMed] [Google Scholar]
  16. Lindvall O., Rehncrona S., Brundin P., Gustavii B., Astedt B., Widner H., Lindholm T., Björklund A., Leenders K. L., Rothwell J. C. Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease. A detailed account of methodology and a 6-month follow-up. Arch Neurol. 1989 Jun;46(6):615–631. doi: 10.1001/archneur.1989.00520420033021. [DOI] [PubMed] [Google Scholar]
  17. Lindvall O., Rehncrona S., Gustavii B., Brundin P., Astedt B., Widner H., Lindholm T., Björklund A., Leenders K. L., Rothwell J. C. Fetal dopamine-rich mesencephalic grafts in Parkinson's disease. Lancet. 1988 Dec 24;2(8626-8627):1483–1484. doi: 10.1016/s0140-6736(88)90950-6. [DOI] [PubMed] [Google Scholar]
  18. Mahowald M. B., Areen J., Hoffer B. J., Jonsen A. R., King P., Silver J., Sladek J. R., Jr, Walters L. Transplantation of neural tissue from fetuses. Science. 1987 Mar 13;235(4794):1307–1308. [PubMed] [Google Scholar]
  19. Marwick C. Fetal tissue study panel nears conclusion. JAMA. 1988 Dec 2;260(21):3108–3109. doi: 10.1001/jama.1988.03410210018007. [DOI] [PubMed] [Google Scholar]
  20. Merz B. Neurologists join neurosurgeons in urging restraint in Parkinson's surgery. JAMA. 1989 May 26;261(20):2929–2929. [PubMed] [Google Scholar]
  21. Perlow M. J., Freed W. J., Hoffer B. J., Seiger A., Olson L., Wyatt R. J. Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science. 1979 May 11;204(4393):643–647. doi: 10.1126/science.571147. [DOI] [PubMed] [Google Scholar]
  22. Quay P. M. Utilizing the bodies of the dead. St Louis Univ Law J. 1984 Aug;28(4):889–927. [PubMed] [Google Scholar]
  23. Redmond D. E., Sladek J. R., Jr, Roth R. H., Collier T. J., Elsworth J. D., Deutch A. Y., Haber S. Fetal neuronal grafts in monkeys given methylphenyltetrahydropyridine. Lancet. 1986 May 17;1(8490):1125–1127. doi: 10.1016/s0140-6736(86)91839-8. [DOI] [PubMed] [Google Scholar]
  24. Robertson J. A. Rights, symbolism, and public policy in fetal tissue transplants. Hastings Cent Rep. 1988 Dec;18(6):5–12. [PubMed] [Google Scholar]
  25. Sladek J. R., Jr, Redmond D. E., Jr, Roth R. H. Transplantation of fetal neurons in primates. Clin Res. 1988 Apr;36(3):200–204. [PubMed] [Google Scholar]
  26. Sladek J. R., Jr, Shoulson I. Neural transplantation: a call for patience rather than patients. Science. 1988 Jun 10;240(4858):1386–1388. doi: 10.1126/science.3375820. [DOI] [PubMed] [Google Scholar]

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