Skip to main content
PMC home page
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1998 Jan;62(1):10–14. doi: 10.1086/301694

Drosophila immune responses as models for human immunity.

M S Dushay 1, E D Eldon 1
PMCID: PMC1376818  PMID: 9443887

Full Text

The Full Text of this article is available as a PDF (236.4 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asling B., Dushay M. S., Hultmark D. Identification of early genes in the Drosophila immune response by PCR-based differential display: the Attacin A gene and the evolution of attacin-like proteins. Insect Biochem Mol Biol. 1995 Apr;25(4):511–518. doi: 10.1016/0965-1748(94)00091-c. [DOI] [PubMed] [Google Scholar]
  2. Baeuerle P. A., Baltimore D. NF-kappa B: ten years after. Cell. 1996 Oct 4;87(1):13–20. doi: 10.1016/s0092-8674(00)81318-5. [DOI] [PubMed] [Google Scholar]
  3. Belvin M. P., Anderson K. V. A conserved signaling pathway: the Drosophila toll-dorsal pathway. Annu Rev Cell Dev Biol. 1996;12:393–416. doi: 10.1146/annurev.cellbio.12.1.393. [DOI] [PubMed] [Google Scholar]
  4. Braun A., Lemaitre B., Lanot R., Zachary D., Meister M. Drosophila immunity: analysis of larval hemocytes by P-element-mediated enhancer trap. Genetics. 1997 Oct;147(2):623–634. doi: 10.1093/genetics/147.2.623. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cociancich S., Bulet P., Hetru C., Hoffmann J. A. The inducible antibacterial peptides of insects. Parasitol Today. 1994 Apr;10(4):132–139. doi: 10.1016/0169-4758(94)90260-7. [DOI] [PubMed] [Google Scholar]
  6. Dushay M. S., Asling B., Hultmark D. Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10343–10347. doi: 10.1073/pnas.93.19.10343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Engström Y., Kadalayil L., Sun S. C., Samakovlis C., Hultmark D., Faye I. kappa B-like motifs regulate the induction of immune genes in Drosophila. J Mol Biol. 1993 Jul 20;232(2):327–333. doi: 10.1006/jmbi.1993.1392. [DOI] [PubMed] [Google Scholar]
  8. Fearon D. T., Locksley R. M. The instructive role of innate immunity in the acquired immune response. Science. 1996 Apr 5;272(5258):50–53. doi: 10.1126/science.272.5258.50. [DOI] [PubMed] [Google Scholar]
  9. Hergannan J. A., Rechhart J. V. Drosophila immunity. Trends Cell Biol. 1997 Aug;7(8):309–316. doi: 10.1016/S0962-8924(97)01087-8. [DOI] [PubMed] [Google Scholar]
  10. Ip Y. T., Reach M., Engstrom Y., Kadalayil L., Cai H., González-Crespo S., Tatei K., Levine M. Dif, a dorsal-related gene that mediates an immune response in Drosophila. Cell. 1993 Nov 19;75(4):753–763. doi: 10.1016/0092-8674(93)90495-c. [DOI] [PubMed] [Google Scholar]
  11. Janeway C. A., Jr The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol Today. 1992 Jan;13(1):11–16. doi: 10.1016/0167-5699(92)90198-G. [DOI] [PubMed] [Google Scholar]
  12. Lemaitre B., Nicolas E., Michaut L., Reichhart J. M., Hoffmann J. A. The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 1996 Sep 20;86(6):973–983. doi: 10.1016/s0092-8674(00)80172-5. [DOI] [PubMed] [Google Scholar]
  13. Liang P., Pardee A. B. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science. 1992 Aug 14;257(5072):967–971. doi: 10.1126/science.1354393. [DOI] [PubMed] [Google Scholar]
  14. Medzhitov R., Preston-Hurlburt P., Janeway C. A., Jr A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 1997 Jul 24;388(6640):394–397. doi: 10.1038/41131. [DOI] [PubMed] [Google Scholar]
  15. Rodriguez A., Zhou Z., Tang M. L., Meller S., Chen J., Bellen H., Kimbrell D. A. Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster. Genetics. 1996 Jun;143(2):929–940. doi: 10.1093/genetics/143.2.929. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Schneider D. S., Hudson K. L., Lin T. Y., Anderson K. V. Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo. Genes Dev. 1991 May;5(5):797–807. doi: 10.1101/gad.5.5.797. [DOI] [PubMed] [Google Scholar]
  17. Sun S. C., Faye I. Cecropia immunoresponsive factor, an insect immunoresponsive factor with DNA-binding properties similar to nuclear-factor kappa B. Eur J Biochem. 1992 Mar 1;204(2):885–892. doi: 10.1111/j.1432-1033.1992.tb16708.x. [DOI] [PubMed] [Google Scholar]
  18. Swingler S., Morris A., Easton A. Tumour necrosis factor alpha and interleukin-1 beta induce specific subunits of NFKB to bind the HIV-1 enhancer: characterisation of transcription factors controlling human immunodeficiency virus type 1 gene expression in neural cells. Biochem Biophys Res Commun. 1994 Aug 30;203(1):623–630. doi: 10.1006/bbrc.1994.2228. [DOI] [PubMed] [Google Scholar]
  19. Williams M. J., Rodriguez A., Kimbrell D. A., Eldon E. D. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. EMBO J. 1997 Oct 15;16(20):6120–6130. doi: 10.1093/emboj/16.20.6120. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Yang Y., Shah J., Klessig D. F. Signal perception and transduction in plant defense responses. Genes Dev. 1997 Jul 1;11(13):1621–1639. doi: 10.1101/gad.11.13.1621. [DOI] [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES