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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1998 May;62(5):1008–1014. doi: 10.1086/301849

Causes, effects, and constraints in the genetics of human longevity.

F Schächter 1
PMCID: PMC1377106  PMID: 9545419

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Selected References

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  1. Abbott M. H., Murphy E. A., Bolling D. R., Abbey H. The familial component in longevity. A study of offspring of nonagenarians. II. Preliminary analysis of the completed study. Johns Hopkins Med J. 1974 Jan;134(1):1–16. [PubMed] [Google Scholar]
  2. Bucher K., Ionasescu V., Hanson J. Frequency of new mutants among boys with Duchenne muscular dystrophy. Am J Med Genet. 1980;7(1):27–34. doi: 10.1002/ajmg.1320070107. [DOI] [PubMed] [Google Scholar]
  3. Cutler R. G. Evolution of human longevity and the genetic complexity governing aging rate. Proc Natl Acad Sci U S A. 1975 Nov;72(11):4664–4668. doi: 10.1073/pnas.72.11.4664. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Finch C. E., Goodman M. F. Relevance of 'adaptive' mutations arising in non-dividing cells of microorganisms to age-related changes in mutant phenotypes of neurons. Trends Neurosci. 1997 Nov;20(11):501–507. doi: 10.1016/s0166-2236(97)01143-0. [DOI] [PubMed] [Google Scholar]
  5. Finch C. E., Rose M. R. Hormones and the physiological architecture of life history evolution. Q Rev Biol. 1995 Mar;70(1):1–52. doi: 10.1086/418864. [DOI] [PubMed] [Google Scholar]
  6. Finch C. E., Tanzi R. E. Genetics of aging. Science. 1997 Oct 17;278(5337):407–411. doi: 10.1126/science.278.5337.407. [DOI] [PubMed] [Google Scholar]
  7. Gavrilov L. A., Gavrilova N. S., Kroutko V. N., Evdokushkina G. N., Semyonova V. G., Gavrilova A. L., Lapshin E. V., Evdokushkina N. N., Kushnareva Y. E. Mutation load and human longevity. Mutat Res. 1997 Jun 9;377(1):61–62. doi: 10.1016/s0027-5107(97)00058-4. [DOI] [PubMed] [Google Scholar]
  8. Ivanova R., Hénon N., Lepage V., Charron D., Vicaut E., Schächter F. HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity. Hum Mol Genet. 1998 Feb;7(2):187–194. doi: 10.1093/hmg/7.2.187. [DOI] [PubMed] [Google Scholar]
  9. Kirkwood T. B., Rose M. R. Evolution of senescence: late survival sacrificed for reproduction. Philos Trans R Soc Lond B Biol Sci. 1991 Apr 29;332(1262):15–24. doi: 10.1098/rstb.1991.0028. [DOI] [PubMed] [Google Scholar]
  10. Lipsitz L. A., Goldberger A. L. Loss of 'complexity' and aging. Potential applications of fractals and chaos theory to senescence. JAMA. 1992 Apr 1;267(13):1806–1809. [PubMed] [Google Scholar]
  11. Macieira-Coelho A. The last mitoses of the human fibroblast proliferative life span, physiopathologic implications. Mech Ageing Dev. 1995 Aug 8;82(2-3):91–104. doi: 10.1016/0047-6374(95)01610-c. [DOI] [PubMed] [Google Scholar]
  12. Mannucci P. M., Mari D., Merati G., Peyvandi F., Tagliabue L., Sacchi E., Taioli E., Sansoni P., Bertolini S., Franceschi C. Gene polymorphisms predicting high plasma levels of coagulation and fibrinolysis proteins. A study in centenarians. Arterioscler Thromb Vasc Biol. 1997 Apr;17(4):755–759. doi: 10.1161/01.atv.17.4.755. [DOI] [PubMed] [Google Scholar]
  13. Mari D., Mannucci P. M., Coppola R., Bottasso B., Bauer K. A., Rosenberg R. D. Hypercoagulability in centenarians: the paradox of successful aging. Blood. 1995 Jun 1;85(11):3144–3149. [PubMed] [Google Scholar]
  14. Martin G. M., Austad S. N., Johnson T. E. Genetic analysis of ageing: role of oxidative damage and environmental stresses. Nat Genet. 1996 May;13(1):25–34. doi: 10.1038/ng0596-25. [DOI] [PubMed] [Google Scholar]
  15. McVean G. T., Hurst L. D. Evidence for a selectively favourable reduction in the mutation rate of the X chromosome. Nature. 1997 Mar 27;386(6623):388–392. doi: 10.1038/386388a0. [DOI] [PubMed] [Google Scholar]
  16. Meltzer P. S., Guan X. Y., Trent J. M. Telomere capture stabilizes chromosome breakage. Nat Genet. 1993 Jul;4(3):252–255. doi: 10.1038/ng0793-252. [DOI] [PubMed] [Google Scholar]
  17. Nuzhdin S. V., Pasyukova E. G., Dilda C. L., Zeng Z. B., Mackay T. F. Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9734–9739. doi: 10.1073/pnas.94.18.9734. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Ono S. Ancient linkage groups and frozen accidents. Nature. 1973 Aug 3;244(5414):259–262. doi: 10.1038/244259a0. [DOI] [PubMed] [Google Scholar]
  19. Paz M. A., Torrelio M., Gallop P. M. X-linked processes in serially passaged "aging" human diploid cells. J Gerontol. 1981 Mar;36(2):142–151. doi: 10.1093/geronj/36.2.142. [DOI] [PubMed] [Google Scholar]
  20. Pincus S. M., Gladstone I. M., Ehrenkranz R. A. A regularity statistic for medical data analysis. J Clin Monit. 1991 Oct;7(4):335–345. doi: 10.1007/BF01619355. [DOI] [PubMed] [Google Scholar]
  21. Qian F., Germino G. G. "Mistakes happen": somatic mutation and disease. Am J Hum Genet. 1997 Nov;61(5):1000–1005. doi: 10.1086/301618. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Radman M., Matic I., Halliday J. A., Taddei F. Editing DNA replication and recombination by mismatch repair: from bacterial genetics to mechanisms of predisposition to cancer in humans. Philos Trans R Soc Lond B Biol Sci. 1995 Jan 30;347(1319):97–103. doi: 10.1098/rstb.1995.0015. [DOI] [PubMed] [Google Scholar]
  23. Reiter R. J. The pineal gland and melatonin in relation to aging: a summary of the theories and of the data. Exp Gerontol. 1995 May-Aug;30(3-4):199–212. doi: 10.1016/0531-5565(94)00045-5. [DOI] [PubMed] [Google Scholar]
  24. Robine J. M., Allard M. The oldest human. Science. 1998 Mar 20;279(5358):1834–1835. doi: 10.1126/science.279.5358.1831h. [DOI] [PubMed] [Google Scholar]
  25. Robinson W. P. The extent, mechanism, and consequences of genetic variation, for recombination rate. Am J Hum Genet. 1996 Dec;59(6):1175–1183. [PMC free article] [PubMed] [Google Scholar]
  26. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993 Apr 29;362(6423):801–809. doi: 10.1038/362801a0. [DOI] [PubMed] [Google Scholar]
  27. Schunkert H., Hense H. W., Holmer S. R., Stender M., Perz S., Keil U., Lorell B. H., Riegger G. A. Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. N Engl J Med. 1994 Jun 9;330(23):1634–1638. doi: 10.1056/NEJM199406093302302. [DOI] [PubMed] [Google Scholar]
  28. Schächter F., Faure-Delanef L., Guénot F., Rouger H., Froguel P., Lesueur-Ginot L., Cohen D. Genetic associations with human longevity at the APOE and ACE loci. Nat Genet. 1994 Jan;6(1):29–32. doi: 10.1038/ng0194-29. [DOI] [PubMed] [Google Scholar]
  29. Sohal R. S., Weindruch R. Oxidative stress, caloric restriction, and aging. Science. 1996 Jul 5;273(5271):59–63. doi: 10.1126/science.273.5271.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Taddei F., Hayakawa H., Bouton M., Cirinesi A., Matic I., Sekiguchi M., Radman M. Counteraction by MutT protein of transcriptional errors caused by oxidative damage. Science. 1997 Oct 3;278(5335):128–130. doi: 10.1126/science.278.5335.128. [DOI] [PubMed] [Google Scholar]
  31. Tischfield J. A. Loss of heterozygosity or: how I learned to stop worrying and love mitotic recombination. Am J Hum Genet. 1997 Nov;61(5):995–999. doi: 10.1086/301617. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Wei J. Y. Age and the cardiovascular system. N Engl J Med. 1992 Dec 10;327(24):1735–1739. doi: 10.1056/NEJM199212103272408. [DOI] [PubMed] [Google Scholar]
  33. Weverling-Rijnsburger A. W., Blauw G. J., Lagaay A. M., Knook D. L., Meinders A. E., Westendorp R. G. Total cholesterol and risk of mortality in the oldest old. Lancet. 1997 Oct 18;350(9085):1119–1123. doi: 10.1016/s0140-6736(97)04430-9. [DOI] [PubMed] [Google Scholar]

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