Skip to main content
NCBI home page
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1998 Jun;62(6):1269–1273. doi: 10.1086/301891

Cytosine methylation and the unequal developmental potentials of the oocyte and sperm genomes.

T H Bestor 1
PMCID: PMC1377170  PMID: 9585619

Full Text

The Full Text of this article is available as a PDF (173.1 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barlow D. P. Methylation and imprinting: from host defense to gene regulation? Science. 1993 Apr 16;260(5106):309–310. doi: 10.1126/science.8469984. [DOI] [PubMed] [Google Scholar]
  2. Bestor T. H. DNA methylation: evolution of a bacterial immune function into a regulator of gene expression and genome structure in higher eukaryotes. Philos Trans R Soc Lond B Biol Sci. 1990 Jan 30;326(1235):179–187. doi: 10.1098/rstb.1990.0002. [DOI] [PubMed] [Google Scholar]
  3. Bestor T. H., Tycko B. Creation of genomic methylation patterns. Nat Genet. 1996 Apr;12(4):363–367. doi: 10.1038/ng0496-363. [DOI] [PubMed] [Google Scholar]
  4. Carlson L. L., Page A. W., Bestor T. H. Properties and localization of DNA methyltransferase in preimplantation mouse embryos: implications for genomic imprinting. Genes Dev. 1992 Dec;6(12B):2536–2541. doi: 10.1101/gad.6.12b.2536. [DOI] [PubMed] [Google Scholar]
  5. Driscoll D. J., Migeon B. R. Sex difference in methylation of single-copy genes in human meiotic germ cells: implications for X chromosome inactivation, parental imprinting, and origin of CpG mutations. Somat Cell Mol Genet. 1990 May;16(3):267–282. doi: 10.1007/BF01233363. [DOI] [PubMed] [Google Scholar]
  6. Efstratiadis A. Parental imprinting of autosomal mammalian genes. Curr Opin Genet Dev. 1994 Apr;4(2):265–280. doi: 10.1016/s0959-437x(05)80054-1. [DOI] [PubMed] [Google Scholar]
  7. Hatada I., Nabetani A., Arai Y., Ohishi S., Suzuki M., Miyabara S., Nishimune Y., Mukai T. Aberrant methylation of an imprinted gene U2af1-rs1(SP2) caused by its own transgene. J Biol Chem. 1997 Apr 4;272(14):9120–9122. doi: 10.1074/jbc.272.14.9120. [DOI] [PubMed] [Google Scholar]
  8. Hurst L. D., McVean G., Moore T. Imprinted genes have few and small introns. Nat Genet. 1996 Mar;12(3):234–237. doi: 10.1038/ng0396-234. [DOI] [PubMed] [Google Scholar]
  9. Issa J. P., Vertino P. M., Boehm C. D., Newsham I. F., Baylin S. B. Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11757–11762. doi: 10.1073/pnas.93.21.11757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jost J. P., Frémont M., Siegmann M., Hofsteenge J. The RNA moiety of chick embryo 5-methylcytosine- DNA glycosylase targets DNA demethylation. Nucleic Acids Res. 1997 Nov 15;25(22):4545–4550. doi: 10.1093/nar/25.22.4545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jue K., Bestor T. H., Trasler J. M. Regulated synthesis and localization of DNA methyltransferase during spermatogenesis. Biol Reprod. 1995 Sep;53(3):561–569. doi: 10.1095/biolreprod53.3.561. [DOI] [PubMed] [Google Scholar]
  12. Kass S. U., Landsberger N., Wolffe A. P. DNA methylation directs a time-dependent repression of transcription initiation. Curr Biol. 1997 Mar 1;7(3):157–165. doi: 10.1016/s0960-9822(97)70086-1. [DOI] [PubMed] [Google Scholar]
  13. Kono T., Obata Y., Yoshimzu T., Nakahara T., Carroll J. Epigenetic modifications during oocyte growth correlates with extended parthenogenetic development in the mouse. Nat Genet. 1996 May;13(1):91–94. doi: 10.1038/ng0596-91. [DOI] [PubMed] [Google Scholar]
  14. LaSalle J. M., Lalande M. Homologous association of oppositely imprinted chromosomal domains. Science. 1996 May 3;272(5262):725–728. doi: 10.1126/science.272.5262.725. [DOI] [PubMed] [Google Scholar]
  15. Lei H., Oh S. P., Okano M., Jüttermann R., Goss K. A., Jaenisch R., Li E. De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development. 1996 Oct;122(10):3195–3205. doi: 10.1242/dev.122.10.3195. [DOI] [PubMed] [Google Scholar]
  16. Leonhardt H., Page A. W., Weier H. U., Bestor T. H. A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell. 1992 Nov 27;71(5):865–873. doi: 10.1016/0092-8674(92)90561-p. [DOI] [PubMed] [Google Scholar]
  17. Li E., Beard C., Forster A. C., Bestor T. H., Jaenisch R. DNA methylation, genomic imprinting, and mammalian development. Cold Spring Harb Symp Quant Biol. 1993;58:297–305. doi: 10.1101/sqb.1993.058.01.035. [DOI] [PubMed] [Google Scholar]
  18. Matsuo K., Silke J., Georgiev O., Marti P., Giovannini N., Rungger D. An embryonic demethylation mechanism involving binding of transcription factors to replicating DNA. EMBO J. 1998 Mar 2;17(5):1446–1453. doi: 10.1093/emboj/17.5.1446. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. McGrath J., Solter D. Completion of mouse embryogenesis requires both the maternal and paternal genomes. Cell. 1984 May;37(1):179–183. doi: 10.1016/0092-8674(84)90313-1. [DOI] [PubMed] [Google Scholar]
  20. Mertineit C., Yoder J. A., Taketo T., Laird D. W., Trasler J. M., Bestor T. H. Sex-specific exons control DNA methyltransferase in mammalian germ cells. Development. 1998 Mar;125(5):889–897. doi: 10.1242/dev.125.5.889. [DOI] [PubMed] [Google Scholar]
  21. Monk M., Boubelik M., Lehnert S. Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development. 1987 Mar;99(3):371–382. doi: 10.1242/dev.99.3.371. [DOI] [PubMed] [Google Scholar]
  22. Mutter G. L. Role of imprinting in abnormal human development. Mutat Res. 1997 Dec 12;396(1-2):141–147. doi: 10.1016/s0027-5107(97)00180-2. [DOI] [PubMed] [Google Scholar]
  23. Nabetani A., Hatada I., Morisaki H., Oshimura M., Mukai T. Mouse U2af1-rs1 is a neomorphic imprinted gene. Mol Cell Biol. 1997 Feb;17(2):789–798. doi: 10.1128/mcb.17.2.789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Ono T., Uehara Y., Kurishita A., Tawa R., Sakurai H. Biological significance of DNA methylation in the ageing process. Age Ageing. 1993 Jan;22(1):S34–S43. doi: 10.1093/ageing/22.suppl_1.s34. [DOI] [PubMed] [Google Scholar]
  25. Sgaramella V., Zinder N. D. Dolly confirmation. Science. 1998 Jan 30;279(5351):635, 637-8. doi: 10.1126/science.279.5351.635c. [DOI] [PubMed] [Google Scholar]
  26. Solter D. Differential imprinting and expression of maternal and paternal genomes. Annu Rev Genet. 1988;22:127–146. doi: 10.1146/annurev.ge.22.120188.001015. [DOI] [PubMed] [Google Scholar]
  27. Sun F. L., Dean W. L., Kelsey G., Allen N. D., Reik W. Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome. Nature. 1997 Oct 23;389(6653):809–815. doi: 10.1038/39797. [DOI] [PubMed] [Google Scholar]
  28. Surani M. A., Barton S. C., Norris M. L. Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis. Nature. 1984 Apr 5;308(5959):548–550. doi: 10.1038/308548a0. [DOI] [PubMed] [Google Scholar]
  29. Tada M., Tada T., Lefebvre L., Barton S. C., Surani M. A. Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells. EMBO J. 1997 Nov 3;16(21):6510–6520. doi: 10.1093/emboj/16.21.6510. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Tate P. H., Bird A. P. Effects of DNA methylation on DNA-binding proteins and gene expression. Curr Opin Genet Dev. 1993 Apr;3(2):226–231. doi: 10.1016/0959-437x(93)90027-m. [DOI] [PubMed] [Google Scholar]
  31. Trasler J. M., Hake L. E., Johnson P. A., Alcivar A. A., Millette C. F., Hecht N. B. DNA methylation and demethylation events during meiotic prophase in the mouse testis. Mol Cell Biol. 1990 Apr;10(4):1828–1834. doi: 10.1128/mcb.10.4.1828. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Tycko B. DNA methylation in genomic imprinting. Mutat Res. 1997 Apr;386(2):131–140. doi: 10.1016/s1383-5742(96)00049-x. [DOI] [PubMed] [Google Scholar]
  33. Weiss A., Keshet I., Razin A., Cedar H. DNA demethylation in vitro: involvement of RNA. Cell. 1996 Sep 6;86(5):709–718. doi: 10.1016/s0092-8674(00)80146-4. [DOI] [PubMed] [Google Scholar]
  34. Wilmut I., Schnieke A. E., McWhir J., Kind A. J., Campbell K. H. Viable offspring derived from fetal and adult mammalian cells. Nature. 1997 Feb 27;385(6619):810–813. doi: 10.1038/385810a0. [DOI] [PubMed] [Google Scholar]
  35. Yoder J. A., Soman N. S., Verdine G. L., Bestor T. H. DNA (cytosine-5)-methyltransferases in mouse cells and tissues. Studies with a mechanism-based probe. J Mol Biol. 1997 Jul 18;270(3):385–395. doi: 10.1006/jmbi.1997.1125. [DOI] [PubMed] [Google Scholar]
  36. Yoder J. A., Walsh C. P., Bestor T. H. Cytosine methylation and the ecology of intragenomic parasites. Trends Genet. 1997 Aug;13(8):335–340. doi: 10.1016/s0168-9525(97)01181-5. [DOI] [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES