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. 1998 Jul;63(1):17–19. doi: 10.1086/301940

X-chromosome inactivation spreads itself: effects in autosomes.

M F Lyon
PMCID: PMC1377259  PMID: 9634536

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boyle A. L., Ballard S. G., Ward D. C. Differential distribution of long and short interspersed element sequences in the mouse genome: chromosome karyotyping by fluorescence in situ hybridization. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7757–7761. doi: 10.1073/pnas.87.19.7757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brown C. J., Willard H. F. The human X-inactivation centre is not required for maintenance of X-chromosome inactivation. Nature. 1994 Mar 10;368(6467):154–156. doi: 10.1038/368154a0. [DOI] [PubMed] [Google Scholar]
  3. Cattanach B. M. Position effect variegation in the mouse. Genet Res. 1974 Jun;23(3):291–306. doi: 10.1017/s0016672300014932. [DOI] [PubMed] [Google Scholar]
  4. Clemson C. M., McNeil J. A., Willard H. F., Lawrence J. B. XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure. J Cell Biol. 1996 Feb;132(3):259–275. doi: 10.1083/jcb.132.3.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Disteche C. M. Escape from X inactivation in human and mouse. Trends Genet. 1995 Jan;11(1):17–22. doi: 10.1016/s0168-9525(00)88981-7. [DOI] [PubMed] [Google Scholar]
  6. Gartler S. M., Dyer K. A., Goldman M. A. Mammalian X chromosome inactivation. Mol Genet Med. 1992;2:121–160. doi: 10.1016/b978-0-12-462002-5.50010-8. [DOI] [PubMed] [Google Scholar]
  7. Gartler S. M., Riggs A. D. Mammalian X-chromosome inactivation. Annu Rev Genet. 1983;17:155–190. doi: 10.1146/annurev.ge.17.120183.001103. [DOI] [PubMed] [Google Scholar]
  8. Herzing L. B., Romer J. T., Horn J. M., Ashworth A. Xist has properties of the X-chromosome inactivation centre. Nature. 1997 Mar 20;386(6622):272–275. doi: 10.1038/386272a0. [DOI] [PubMed] [Google Scholar]
  9. Korenberg J. R., Rykowski M. C. Human genome organization: Alu, lines, and the molecular structure of metaphase chromosome bands. Cell. 1988 May 6;53(3):391–400. doi: 10.1016/0092-8674(88)90159-6. [DOI] [PubMed] [Google Scholar]
  10. Lee J. T., Jaenisch R. Long-range cis effects of ectopic X-inactivation centres on a mouse autosome. Nature. 1997 Mar 20;386(6622):275–279. doi: 10.1038/386275a0. [DOI] [PubMed] [Google Scholar]
  11. Lee J. T., Strauss W. M., Dausman J. A., Jaenisch R. A 450 kb transgene displays properties of the mammalian X-inactivation center. Cell. 1996 Jul 12;86(1):83–94. doi: 10.1016/s0092-8674(00)80079-3. [DOI] [PubMed] [Google Scholar]
  12. Marahrens Y., Panning B., Dausman J., Strauss W., Jaenisch R. Xist-deficient mice are defective in dosage compensation but not spermatogenesis. Genes Dev. 1997 Jan 15;11(2):156–166. doi: 10.1101/gad.11.2.156. [DOI] [PubMed] [Google Scholar]
  13. Panning B., Jaenisch R. DNA hypomethylation can activate Xist expression and silence X-linked genes. Genes Dev. 1996 Aug 15;10(16):1991–2002. doi: 10.1101/gad.10.16.1991. [DOI] [PubMed] [Google Scholar]
  14. Penny G. D., Kay G. F., Sheardown S. A., Rastan S., Brockdorff N. Requirement for Xist in X chromosome inactivation. Nature. 1996 Jan 11;379(6561):131–137. doi: 10.1038/379131a0. [DOI] [PubMed] [Google Scholar]
  15. RUSSELL L. B. Mammalian X-chromosome action: inactivation limited in spread and region of origin. Science. 1963 May 31;140(3570):976–978. doi: 10.1126/science.140.3570.976. [DOI] [PubMed] [Google Scholar]
  16. Rack K. A., Chelly J., Gibbons R. J., Rider S., Benjamin D., Lafreniére R. G., Oscier D., Hendriks R. W., Craig I. W., Willard H. F. Absence of the XIST gene from late-replicating isodicentric X chromosomes in leukaemia. Hum Mol Genet. 1994 Jul;3(7):1053–1059. doi: 10.1093/hmg/3.7.1053. [DOI] [PubMed] [Google Scholar]
  17. Rastan S. Non-random X-chromosome inactivation in mouse X-autosome translocation embryos--location of the inactivation centre. J Embryol Exp Morphol. 1983 Dec;78:1–22. [PubMed] [Google Scholar]
  18. Russell L. B., Montgomery C. S. Comparative studies on X-autosome translocations in the mouse. II. Inactivation of autosomal loci, segregation, and mapping of autosomal breakpoints in five T (X;1) S. Genetics. 1970 Feb;64(2):281–312. doi: 10.1093/genetics/64.2.281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Wareham K. A., Lyon M. F., Glenister P. H., Williams E. D. Age related reactivation of an X-linked gene. 1987 Jun 25-Jul 1Nature. 327(6124):725–727. doi: 10.1038/327725a0. [DOI] [PubMed] [Google Scholar]
  20. White W. M., Willard H. F., Van Dyke D. L., Wolff D. J. The spreading of X inactivation into autosomal material of an x;autosome translocation: evidence for a difference between autosomal and X-chromosomal DNA. Am J Hum Genet. 1998 Jul;63(1):20–28. doi: 10.1086/301922. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Wolffe A. P. Transcription control: repressed repeats express themselves. Curr Biol. 1997 Dec 1;7(12):R796–R798. doi: 10.1016/s0960-9822(06)00408-8. [DOI] [PubMed] [Google Scholar]

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