Skip to main content
NCBI home page
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1998 Jul;63(1):6–10. doi: 10.1086/301942

Nm23-H1: genetic alterations and expression patterns in tumor metastasis.

M T Hartsough 1, P S Steeg 1
PMCID: PMC1377261  PMID: 9634538

Full Text

The Full Text of this article is available as a PDF (179.4 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Appleby J. L., Parkinson J. S., Bourret R. B. Signal transduction via the multi-step phosphorelay: not necessarily a road less traveled. Cell. 1996 Sep 20;86(6):845–848. doi: 10.1016/s0092-8674(00)80158-0. [DOI] [PubMed] [Google Scholar]
  2. Biggs J., Hersperger E., Steeg P. S., Liotta L. A., Shearn A. A Drosophila gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase. Cell. 1990 Nov 30;63(5):933–940. doi: 10.1016/0092-8674(90)90496-2. [DOI] [PubMed] [Google Scholar]
  3. Chang C. L., Strahler J. R., Thoraval D. H., Qian M. G., Hinderer R., Hanash S. M. A nucleoside diphosphate kinase A (nm23-H1) serine 120-->glycine substitution in advanced stage neuroblastoma affects enzyme stability and alters protein-protein interaction. Oncogene. 1996 Feb 1;12(3):659–667. [PubMed] [Google Scholar]
  4. Chang C. L., Zhu X. X., Thoraval D. H., Ungar D., Rawwas J., Hora N., Strahler J. R., Hanash S. M., Radany E. Nm23-H1 mutation in neuroblastoma. Nature. 1994 Aug 4;370(6488):335–336. doi: 10.1038/370335a0. [DOI] [PubMed] [Google Scholar]
  5. Cropp C. S., Lidereau R., Leone A., Liscia D., Cappa A. P., Campbell G., Barker E., Le Doussal V., Steeg P. S., Callahan R. NME1 protein expression and loss of heterozygosity mutations in primary human breast tumors. J Natl Cancer Inst. 1994 Aug 3;86(15):1167–1169. doi: 10.1093/jnci/86.15.1167. [DOI] [PubMed] [Google Scholar]
  6. Freije J. M., Blay P., MacDonald N. J., Manrow R. E., Steeg P. S. Site-directed mutation of Nm23-H1. Mutations lacking motility suppressive capacity upon transfection are deficient in histidine-dependent protein phosphotransferase pathways in vitro. J Biol Chem. 1997 Feb 28;272(9):5525–5532. doi: 10.1074/jbc.272.9.5525. [DOI] [PubMed] [Google Scholar]
  7. Futreal P. A., Söderkvist P., Marks J. R., Iglehart J. D., Cochran C., Barrett J. C., Wiseman R. W. Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms. Cancer Res. 1992 May 1;52(9):2624–2627. [PubMed] [Google Scholar]
  8. Gervasi F., D'Agnano I., Vossio S., Zupi G., Sacchi A., Lombardi D. nm23 influences proliferation and differentiation of PC12 cells in response to nerve growth factor. Cell Growth Differ. 1996 Dec;7(12):1689–1695. [PubMed] [Google Scholar]
  9. Howlett A. R., Petersen O. W., Steeg P. S., Bissell M. J. A novel function for the nm23-H1 gene: overexpression in human breast carcinoma cells leads to the formation of basement membrane and growth arrest. J Natl Cancer Inst. 1994 Dec 21;86(24):1838–1844. doi: 10.1093/jnci/86.24.1838. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lascu I., Chaffotte A., Limbourg-Bouchon B., Véron M. A Pro/Ser substitution in nucleoside diphosphate kinase of Drosophila melanogaster (mutation killer of prune) affects stability but not catalytic efficiency of the enzyme. J Biol Chem. 1992 Jun 25;267(18):12775–12781. [PubMed] [Google Scholar]
  11. Lascu I., Schaertl S., Wang C., Sarger C., Giartosio A., Briand G., Lacombe M. L., Konrad M. A point mutation of human nucleoside diphosphate kinase A found in aggressive neuroblastoma affects protein folding. J Biol Chem. 1997 Jun 20;272(25):15599–15602. doi: 10.1074/jbc.272.25.15599. [DOI] [PubMed] [Google Scholar]
  12. Leone A., Flatow U., King C. R., Sandeen M. A., Margulies I. M., Liotta L. A., Steeg P. S. Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Cell. 1991 Apr 5;65(1):25–35. doi: 10.1016/0092-8674(91)90404-m. [DOI] [PubMed] [Google Scholar]
  13. Leone A., Flatow U., VanHoutte K., Steeg P. S. Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: effects on tumor metastatic potential, colonization and enzymatic activity. Oncogene. 1993 Sep;8(9):2325–2333. [PubMed] [Google Scholar]
  14. Leone A., McBride O. W., Weston A., Wang M. G., Anglard P., Cropp C. S., Goepel J. R., Lidereau R., Callahan R., Linehan W. M. Somatic allelic deletion of nm23 in human cancer. Cancer Res. 1991 May 1;51(9):2490–2493. [PubMed] [Google Scholar]
  15. Leone A., Seeger R. C., Hong C. M., Hu Y. Y., Arboleda M. J., Brodeur G. M., Stram D., Slamon D. J., Steeg P. S. Evidence for nm23 RNA overexpression, DNA amplification and mutation in aggressive childhood neuroblastomas. Oncogene. 1993 Apr;8(4):855–865. [PubMed] [Google Scholar]
  16. Liotta L. A., Steeg P. S., Stetler-Stevenson W. G. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell. 1991 Jan 25;64(2):327–336. doi: 10.1016/0092-8674(91)90642-c. [DOI] [PubMed] [Google Scholar]
  17. Lu Q., Park H., Egger L. A., Inouye M. Nucleoside-diphosphate kinase-mediated signal transduction via histidyl-aspartyl phosphorelay systems in Escherichia coli. J Biol Chem. 1996 Dec 20;271(51):32886–32893. doi: 10.1074/jbc.271.51.32886. [DOI] [PubMed] [Google Scholar]
  18. MacDonald N. J., De la Rosa A., Benedict M. A., Freije J. M., Krutsch H., Steeg P. S. A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential. J Biol Chem. 1993 Dec 5;268(34):25780–25789. [PubMed] [Google Scholar]
  19. MacDonald N. J., Freije J. M., Stracke M. L., Manrow R. E., Steeg P. S. Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells. J Biol Chem. 1996 Oct 11;271(41):25107–25116. doi: 10.1074/jbc.271.41.25107. [DOI] [PubMed] [Google Scholar]
  20. Maeda T., Wurgler-Murphy S. M., Saito H. A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature. 1994 May 19;369(6477):242–245. doi: 10.1038/369242a0. [DOI] [PubMed] [Google Scholar]
  21. Posas F., Wurgler-Murphy S. M., Maeda T., Witten E. A., Thai T. C., Saito H. Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor. Cell. 1996 Sep 20;86(6):865–875. doi: 10.1016/s0092-8674(00)80162-2. [DOI] [PubMed] [Google Scholar]
  22. Spurr N. K., Kelsell D. P., Black D. M., Murday V. A., Turner G., Crockford G. P., Solomon E., Cartwright R. A., Bishop D. T. Linkage analysis of early-onset breast and ovarian cancer families, with markers on the long arm of chromosome 17. Am J Hum Genet. 1993 Apr;52(4):777–785. [PMC free article] [PubMed] [Google Scholar]
  23. Steeg P. S., Bevilacqua G., Kopper L., Thorgeirsson U. P., Talmadge J. E., Liotta L. A., Sobel M. E. Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst. 1988 Apr 6;80(3):200–204. doi: 10.1093/jnci/80.3.200. [DOI] [PubMed] [Google Scholar]
  24. Steeg P. S. Genetic control of the metastatic phenotype. Semin Cancer Biol. 1991 Apr;2(2):105–110. [PubMed] [Google Scholar]
  25. Timmons L., Shearn A. prune/Killer of prune: a conditional dominant lethal interaction in Drosophila. Adv Genet. 1997;35:207–252. doi: 10.1016/s0065-2660(08)60451-4. [DOI] [PubMed] [Google Scholar]
  26. Wagner P. D., Steeg P. S., Vu N. D. Two-component kinase-like activity of nm23 correlates with its motility-suppressing activity. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9000–9005. doi: 10.1073/pnas.94.17.9000. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Watatani M., Nagayama K., Imanishi Y., Kurooka K., Wada T., Inui H., Hirai K., Ozaki M., Yasutomi M. Genetic alterations on chromosome 17 in human breast cancer: relationships to clinical features and DNA ploidy. Breast Cancer Res Treat. 1993 Dec;28(3):231–239. doi: 10.1007/BF00666584. [DOI] [PubMed] [Google Scholar]
  28. Welch D. R. Technical considerations for studying cancer metastasis in vivo. Clin Exp Metastasis. 1997 May;15(3):272–306. doi: 10.1023/a:1018477516367. [DOI] [PubMed] [Google Scholar]
  29. Yagüe J., Juan M., Leone A., Romero M., Cardesa A., Vives J., Steeg P. S., Campo E. BglII and EcoRI polymorphism of the human nm23-H1 gene (NME1). Nucleic Acids Res. 1991 Dec 11;19(23):6663–6663. doi: 10.1093/nar/19.23.6663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. de la Rosa A., Mikhak B., Steeg P. S. Identification and characterization of the promoter for the human metastasis suppressor gene nm23-H1. Arch Med Res. 1996 Autumn;27(3):395–401. [PubMed] [Google Scholar]
  31. de la Rosa A., Williams R. L., Steeg P. S. Nm23/nucleoside diphosphate kinase: toward a structural and biochemical understanding of its biological functions. Bioessays. 1995 Jan;17(1):53–62. doi: 10.1002/bies.950170111. [DOI] [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES