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- Ashley-Koch A. E., Robinson H., Glicksman A. E., Nolin S. L., Schwartz C. E., Brown W. T., Turner G., Sherman S. L. Examination of factors associated with instability of the FMR1 CGG repeat. Am J Hum Genet. 1998 Sep;63(3):776–785. doi: 10.1086/302018. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carapeti M., Aguiar R. C., Sill H., Goldman J. M., Cross N. C. Aberrant transcripts of the FHIT gene are expressed in normal and leukaemic haemopoietic cells. Br J Cancer. 1998 Sep;78(5):601–605. doi: 10.1038/bjc.1998.547. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Coquelle A., Toledo F., Stern S., Bieth A., Debatisse M. A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs. Mol Cell. 1998 Aug;2(2):259–265. doi: 10.1016/s1097-2765(00)80137-9. [DOI] [PubMed] [Google Scholar]
- Engelman J. A., Zhang X. L., Lisanti M. P. Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers. FEBS Lett. 1998 Oct 9;436(3):403–410. doi: 10.1016/s0014-5793(98)01134-x. [DOI] [PubMed] [Google Scholar]
- Engelman J. A., Zhang X., Galbiati F., Volonte D., Sotgia F., Pestell R. G., Minetti C., Scherer P. E., Okamoto T., Lisanti M. P. Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy. Am J Hum Genet. 1998 Dec;63(6):1578–1587. doi: 10.1086/302172. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Falik-Zaccai T. C., Shachak E., Yalon M., Lis Z., Borochowitz Z., Macpherson J. N., Nelson D. L., Eichler E. E. Predisposition to the fragile X syndrome in Jews of Tunisian descent is due to the absence of AGG interruptions on a rare Mediterranean haplotype. Am J Hum Genet. 1997 Jan;60(1):103–112. [PMC free article] [PubMed] [Google Scholar]
- Freudenreich C. H., Kantrow S. M., Zakian V. A. Expansion and length-dependent fragility of CTG repeats in yeast. Science. 1998 Feb 6;279(5352):853–856. doi: 10.1126/science.279.5352.853. [DOI] [PubMed] [Google Scholar]
- Galbiati F., Volonte D., Engelman J. A., Watanabe G., Burk R., Pestell R. G., Lisanti M. P. Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. EMBO J. 1998 Nov 16;17(22):6633–6648. doi: 10.1093/emboj/17.22.6633. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gunter C., Paradee W., Crawford D. C., Meadows K. A., Newman J., Kunst C. B., Nelson D. L., Schwartz C., Murray A., Macpherson J. N. Re-examination of factors associated with expansion of CGG repeats using a single nucleotide polymorphism in FMR1. Hum Mol Genet. 1998 Nov;7(12):1935–1946. doi: 10.1093/hmg/7.12.1935. [DOI] [PubMed] [Google Scholar]
- Hansen R. S., Canfield T. K., Fjeld A. D., Mumm S., Laird C. D., Gartler S. M. A variable domain of delayed replication in FRAXA fragile X chromosomes: X inactivation-like spread of late replication. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4587–4592. doi: 10.1073/pnas.94.9.4587. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hewett D. R., Handt O., Hobson L., Mangelsdorf M., Eyre H. J., Baker E., Sutherland G. R., Schuffenhauer S., Mao J. I., Richards R. I. FRA10B structure reveals common elements in repeat expansion and chromosomal fragile site genesis. Mol Cell. 1998 May;1(6):773–781. doi: 10.1016/s1097-2765(00)80077-5. [DOI] [PubMed] [Google Scholar]
- Hirst M. C., Grewal P. K., Davies K. E. Precursor arrays for triplet repeat expansion at the fragile X locus. Hum Mol Genet. 1994 Sep;3(9):1553–1560. doi: 10.1093/hmg/3.9.1553. [DOI] [PubMed] [Google Scholar]
- Huang H., Qian C., Jenkins R. B., Smith D. I. Fish mapping of YAC clones at human chromosomal band 7q31.2: identification of YACS spanning FRA7G within the common region of LOH in breast and prostate cancer. Genes Chromosomes Cancer. 1998 Feb;21(2):152–159. doi: 10.1002/(sici)1098-2264(199802)21:2<152::aid-gcc11>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
- Inoue H., Ishii H., Alder H., Snyder E., Druck T., Huebner K., Croce C. M. Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14584–14589. doi: 10.1073/pnas.94.26.14584. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jeffreys A. J., Tamaki K., MacLeod A., Monckton D. G., Neil D. L., Armour J. A. Complex gene conversion events in germline mutation at human minisatellites. Nat Genet. 1994 Feb;6(2):136–145. doi: 10.1038/ng0294-136. [DOI] [PubMed] [Google Scholar]
- Jones C., Penny L., Mattina T., Yu S., Baker E., Voullaire L., Langdon W. Y., Sutherland G. R., Richards R. I., Tunnacliffe A. Association of a chromosome deletion syndrome with a fragile site within the proto-oncogene CBL2. Nature. 1995 Jul 13;376(6536):145–149. doi: 10.1038/376145a0. [DOI] [PubMed] [Google Scholar]
- Le Beau M. M., Rassool F. V., Neilly M. E., Espinosa R., 3rd, Glover T. W., Smith D. I., McKeithan T. W. Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction. Hum Mol Genet. 1998 Apr;7(4):755–761. doi: 10.1093/hmg/7.4.755. [DOI] [PubMed] [Google Scholar]
- Li Z., Bailey A. D., Buchowski J., Weiner A. M. A tandem array of minimal U1 small nuclear RNA genes is sufficient to generate a new adenovirus type 12-inducible chromosome fragile site. J Virol. 1998 May;72(5):4205–4211. doi: 10.1128/jvi.72.5.4205-4211.1998. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Malter H. E., Iber J. C., Willemsen R., de Graaff E., Tarleton J. C., Leisti J., Warren S. T., Oostra B. A. Characterization of the full fragile X syndrome mutation in fetal gametes. Nat Genet. 1997 Feb;15(2):165–169. doi: 10.1038/ng0297-165. [DOI] [PubMed] [Google Scholar]
- Mishmar D., Rahat A., Scherer S. W., Nyakatura G., Hinzmann B., Kohwi Y., Mandel-Gutfroind Y., Lee J. R., Drescher B., Sas D. E. Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8141–8146. doi: 10.1073/pnas.95.14.8141. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nancarrow J. K., Holman K., Mangelsdorf M., Hori T., Denton M., Sutherland G. R., Richards R. I. Molecular basis of p(CCG)n repeat instability at the FRA16A fragile site locus. Hum Mol Genet. 1995 Mar;4(3):367–372. doi: 10.1093/hmg/4.3.367. [DOI] [PubMed] [Google Scholar]
- Nancarrow J. K., Kremer E., Holman K., Eyre H., Doggett N. A., Le Paslier D., Callen D. F., Sutherland G. R., Richards R. I. Implications of FRA16A structure for the mechanism of chromosomal fragile site genesis. Science. 1994 Jun 24;264(5167):1938–1941. doi: 10.1126/science.8009225. [DOI] [PubMed] [Google Scholar]
- Otterson G. A., Xiao G. H., Geradts J., Jin F., Chen W. D., Niklinska W., Kaye F. J., Yeung R. S. Protein expression and functional analysis of the FHIT gene in human tumor cells. J Natl Cancer Inst. 1998 Mar 18;90(6):426–432. doi: 10.1093/jnci/90.6.426. [DOI] [PubMed] [Google Scholar]
- Palin A. H., Critcher R., Fitzgerald D. J., Anderson J. N., Farr C. J. Direct cloning and analysis of DNA sequences from a region of the Chinese hamster genome associated with aphidicolin-sensitive fragility. J Cell Sci. 1998 Jun;111(Pt 12):1623–1634. doi: 10.1242/jcs.111.12.1623. [DOI] [PubMed] [Google Scholar]
- Richards R. I., Holman K., Friend K., Kremer E., Hillen D., Staples A., Brown W. T., Goonewardena P., Tarleton J., Schwartz C. Evidence of founder chromosomes in fragile X syndrome. Nat Genet. 1992 Jul;1(4):257–260. doi: 10.1038/ng0792-257. [DOI] [PubMed] [Google Scholar]
- Richards R. I., Sutherland G. R. Simple repeat DNA is not replicated simply. Nat Genet. 1994 Feb;6(2):114–116. doi: 10.1038/ng0294-114. [DOI] [PubMed] [Google Scholar]
- Rousseau F., Heitz D., Oberlé I., Mandel J. L. Selection in blood cells from female carriers of the fragile X syndrome: inverse correlation between age and proportion of active X chromosomes carrying the full mutation. J Med Genet. 1991 Dec;28(12):830–836. doi: 10.1136/jmg.28.12.830. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sarkar P. S., Chang H. C., Boudi F. B., Reddy S. CTG repeats show bimodal amplification in E. coli. Cell. 1998 Nov 13;95(4):531–540. doi: 10.1016/s0092-8674(00)81620-7. [DOI] [PubMed] [Google Scholar]
- Schmid M., Feichtinger W., Jessberger A., Köhler J., Lange R. The fragile site (16) (q22). I. Induction by AT-specific DNA-ligands and population frequency. Hum Genet. 1986 Sep;74(1):67–73. doi: 10.1007/BF00278788. [DOI] [PubMed] [Google Scholar]
- Sinden R. R. Biological implications of the DNA structures associated with disease-causing triplet repeats. Am J Hum Genet. 1999 Feb;64(2):346–353. doi: 10.1086/302271. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Siprashvili Z., Sozzi G., Barnes L. D., McCue P., Robinson A. K., Eryomin V., Sard L., Tagliabue E., Greco A., Fusetti L. Replacement of Fhit in cancer cells suppresses tumorigenicity. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13771–13776. doi: 10.1073/pnas.94.25.13771. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smeets D. F., Scheres J. M., Hustinx T. W. The most common fragile site in man is 3p14. Hum Genet. 1986 Mar;72(3):215–220. doi: 10.1007/BF00291880. [DOI] [PubMed] [Google Scholar]
- Yu S., Mangelsdorf M., Hewett D., Hobson L., Baker E., Eyre H. J., Lapsys N., Le Paslier D., Doggett N. A., Sutherland G. R. Human chromosomal fragile site FRA16B is an amplified AT-rich minisatellite repeat. Cell. 1997 Feb 7;88(3):367–374. doi: 10.1016/s0092-8674(00)81875-9. [DOI] [PubMed] [Google Scholar]