Skip to main content
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1999 Feb;64(2):619–628. doi: 10.1086/302242

The central Siberian origin for native American Y chromosomes.

F R Santos 1, A Pandya 1, C Tyler-Smith 1, S D Pena 1, M Schanfield 1, W R Leonard 1, L Osipova 1, M H Crawford 1, R J Mitchell 1
PMCID: PMC1377773  PMID: 9973301

Abstract

Y chromosomal DNA polymorphisms were used to investigate Pleistocene male migrations to the American continent. In a worldwide sample of 306 men, we obtained 32 haplotypes constructed with the variation found in 30 distinct polymorphic sites. The major Y haplotype present in most Native Americans was traced back to recent ancestors common with Siberians, namely, the Kets and Altaians from the Yenissey River Basin and Altai Mountains, respectively. Going further back, the next common ancestor gave rise also to Caucasoid Y chromosomes, probably from the central Eurasian region. This study, therefore, suggests a predominantly central Siberian origin for Native American paternal lineages for those who could have migrated to the Americas during the Upper Pleistocene.

Full Text

The Full Text of this article is available as a PDF (284.6 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bandelt H. J., Forster P., Sykes B. C., Richards M. B. Mitochondrial portraits of human populations using median networks. Genetics. 1995 Oct;141(2):743–753. doi: 10.1093/genetics/141.2.743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barbujani G., Magagni A., Minch E., Cavalli-Sforza L. L. An apportionment of human DNA diversity. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4516–4519. doi: 10.1073/pnas.94.9.4516. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bonatto S. L., Salzano F. M. A single and early migration for the peopling of the Americas supported by mitochondrial DNA sequence data. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1866–1871. doi: 10.1073/pnas.94.5.1866. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Forster P., Harding R., Torroni A., Bandelt H. J. Origin and evolution of Native American mtDNA variation: a reappraisal. Am J Hum Genet. 1996 Oct;59(4):935–945. [PMC free article] [PubMed] [Google Scholar]
  5. Hammer M. F., Horai S. Y chromosomal DNA variation and the peopling of Japan. Am J Hum Genet. 1995 Apr;56(4):951–962. [PMC free article] [PubMed] [Google Scholar]
  6. Jobling M. A., Pandya A., Tyler-Smith C. The Y chromosome in forensic analysis and paternity testing. Int J Legal Med. 1997;110(3):118–124. doi: 10.1007/s004140050050. [DOI] [PubMed] [Google Scholar]
  7. Jobling M. A., Tyler-Smith C. Fathers and sons: the Y chromosome and human evolution. Trends Genet. 1995 Nov;11(11):449–456. doi: 10.1016/s0168-9525(00)89144-1. [DOI] [PubMed] [Google Scholar]
  8. Karafet T., Zegura S. L., Vuturo-Brady J., Posukh O., Osipova L., Wiebe V., Romero F., Long J. C., Harihara S., Jin F. Y chromosome markers and Trans-Bering Strait dispersals. Am J Phys Anthropol. 1997 Mar;102(3):301–314. doi: 10.1002/(SICI)1096-8644(199703)102:3<301::AID-AJPA1>3.0.CO;2-Y. [DOI] [PubMed] [Google Scholar]
  9. Kolman C. J., Sambuughin N., Bermingham E. Mitochondrial DNA analysis of Mongolian populations and implications for the origin of New World founders. Genetics. 1996 Apr;142(4):1321–1334. doi: 10.1093/genetics/142.4.1321. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lell J. T., Brown M. D., Schurr T. G., Sukernik R. I., Starikovskaya Y. B., Torroni A., Moore L. G., Troup G. M., Wallace D. C. Y chromosome polymorphisms in native American and Siberian populations: identification of native American Y chromosome haplotypes. Hum Genet. 1997 Oct;100(5-6):536–543. doi: 10.1007/s004390050548. [DOI] [PubMed] [Google Scholar]
  11. Mathias N., Bayés M., Tyler-Smith C. Highly informative compound haplotypes for the human Y chromosome. Hum Mol Genet. 1994 Jan;3(1):115–123. doi: 10.1093/hmg/3.1.115. [DOI] [PubMed] [Google Scholar]
  12. Merriwether D. A., Hall W. W., Vahlne A., Ferrell R. E. mtDNA variation indicates Mongolia may have been the source for the founding population for the New World. Am J Hum Genet. 1996 Jul;59(1):204–212. [PMC free article] [PubMed] [Google Scholar]
  13. Merriwether D. A., Rothhammer F., Ferrell R. E. Distribution of the four founding lineage haplotypes in Native Americans suggests a single wave of migration for the New World. Am J Phys Anthropol. 1995 Dec;98(4):411–430. doi: 10.1002/ajpa.1330980404. [DOI] [PubMed] [Google Scholar]
  14. Morell V. Genes may link ancient Eurasians, Native Americans. Science. 1998 Apr 24;280(5363):520–520. doi: 10.1126/science.280.5363.520. [DOI] [PubMed] [Google Scholar]
  15. Neel J. V., Biggar R. J., Sukernik R. I. Virologic and genetic studies relate Amerind origins to the indigenous people of the Mongolia/Manchuria/southeastern Siberia region. Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10737–10741. doi: 10.1073/pnas.91.22.10737. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Page R. D. TreeView: an application to display phylogenetic trees on personal computers. Comput Appl Biosci. 1996 Aug;12(4):357–358. doi: 10.1093/bioinformatics/12.4.357. [DOI] [PubMed] [Google Scholar]
  17. Pena S. D., Santos F. R., Bianchi N. O., Bravi C. M., Carnese F. R., Rothhammer F., Gerelsaikhan T., Munkhtuja B., Oyunsuren T. A major founder Y-chromosome haplotype in Amerindians. Nat Genet. 1995 Sep;11(1):15–16. doi: 10.1038/ng0995-15. [DOI] [PubMed] [Google Scholar]
  18. Poloni E. S., Semino O., Passarino G., Santachiara-Benerecetti A. S., Dupanloup I., Langaney A., Excoffier L. Human genetic affinities for Y-chromosome P49a,f/TaqI haplotypes show strong correspondence with linguistics. Am J Hum Genet. 1997 Nov;61(5):1015–1035. doi: 10.1086/301602. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rodriguez-Delfin L., Santos S. E., Zago M. A. Diversity of the human Y chromosome of South American Amerindians: a comparison with blacks, whites, and Japanese from Brazil. Ann Hum Genet. 1997 Sep;61(Pt 5):439–448. doi: 10.1046/j.1469-1809.1997.6150439.x. [DOI] [PubMed] [Google Scholar]
  20. Santos F. R., Bianchi N. O., Pena S. D. Worldwide distribution of human Y-chromosome haplotypes. Genome Res. 1996 Jul;6(7):601–611. doi: 10.1101/gr.6.7.601. [DOI] [PubMed] [Google Scholar]
  21. Santos F. R., Pena S. D., Tyler-Smith C. PCR haplotypes for the human Y chromosome based on alphoid satellite DNA variants and heteroduplex analysis. Gene. 1995 Nov 20;165(2):191–198. doi: 10.1016/0378-1119(95)00501-v. [DOI] [PubMed] [Google Scholar]
  22. Santos F. R., Rodriguez-Delfin L., Pena S. D., Moore J., Weiss K. M. North and South Amerindians may have the same major founder Y chromosome haplotype. Am J Hum Genet. 1996 Jun;58(6):1369–1370. [PMC free article] [PubMed] [Google Scholar]
  23. Schanfield M. S. Immunoglobulin allotypes (GM and KM) indicate multiple founding populations of Native Americans: evidence of at least four migrations to the New World. Hum Biol. 1992 Jun;64(3):381–402. [PubMed] [Google Scholar]
  24. Torroni A., Schurr T. G., Cabell M. F., Brown M. D., Neel J. V., Larsen M., Smith D. G., Vullo C. M., Wallace D. C. Asian affinities and continental radiation of the four founding Native American mtDNAs. Am J Hum Genet. 1993 Sep;53(3):563–590. [PMC free article] [PubMed] [Google Scholar]
  25. Underhill P. A., Jin L., Lin A. A., Mehdi S. Q., Jenkins T., Vollrath D., Davis R. W., Cavalli-Sforza L. L., Oefner P. J. Detection of numerous Y chromosome biallelic polymorphisms by denaturing high-performance liquid chromatography. Genome Res. 1997 Oct;7(10):996–1005. doi: 10.1101/gr.7.10.996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Underhill P. A., Jin L., Zemans R., Oefner P. J., Cavalli-Sforza L. L. A pre-Columbian Y chromosome-specific transition and its implications for human evolutionary history. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):196–200. doi: 10.1073/pnas.93.1.196. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Waters M. R., Forman S. L., Pierson J. M. Diring Yuriakh: A lower paleolithic site in central Siberia. Science. 1997 Feb 28;275(5304):1281–1284. doi: 10.1126/science.275.5304.1281. [DOI] [PubMed] [Google Scholar]
  28. Whitfield L. S., Sulston J. E., Goodfellow P. N. Sequence variation of the human Y chromosome. Nature. 1995 Nov 23;378(6555):379–380. doi: 10.1038/378379a0. [DOI] [PubMed] [Google Scholar]
  29. Zerjal T., Dashnyam B., Pandya A., Kayser M., Roewer L., Santos F. R., Schiefenhövel W., Fretwell N., Jobling M. A., Harihara S. Genetic relationships of Asians and Northern Europeans, revealed by Y-chromosomal DNA analysis. Am J Hum Genet. 1997 May;60(5):1174–1183. [PMC free article] [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES