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. 1999 Mar;64(3):673–677. doi: 10.1086/302304

Nitric oxide in endothelial dysfunction and vascular remodeling: clinical correlates and experimental links.

R D Rudic 1, W C Sessa 1
PMCID: PMC1377782  PMID: 10052999

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Selected References

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  1. Birnbaum Y., Fishbein M. C., Luo H., Nishioka T., Siegel R. J. Regional remodeling of atherosclerotic arteries: a major determinant of clinical manifestations of disease. J Am Coll Cardiol. 1997 Nov 1;30(5):1149–1164. doi: 10.1016/s0735-1097(97)00320-3. [DOI] [PubMed] [Google Scholar]
  2. Bonnardeaux A., Nadaud S., Charru A., Jeunemaitre X., Corvol P., Soubrier F. Lack of evidence for linkage of the endothelial cell nitric oxide synthase gene to essential hypertension. Circulation. 1995 Jan 1;91(1):96–102. doi: 10.1161/01.cir.91.1.96. [DOI] [PubMed] [Google Scholar]
  3. Davies P. F. Flow-mediated endothelial mechanotransduction. Physiol Rev. 1995 Jul;75(3):519–560. doi: 10.1152/physrev.1995.75.3.519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Deng A. Y., Rapp J. P. Absence of linkage for "endothelial" nitric oxide synthase locus to blood pressure in Dahl rats. Hypertension. 1997 Jan;29(1 Pt 1):49–52. doi: 10.1161/01.hyp.29.1.49. [DOI] [PubMed] [Google Scholar]
  5. Furchgott R. F., Zawadzki J. V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980 Nov 27;288(5789):373–376. doi: 10.1038/288373a0. [DOI] [PubMed] [Google Scholar]
  6. Ghiadoni L., Taddei S., Virdis A., Sudano I., Di Legge V., Meola M., Di Venanzio L., Salvetti A. Endothelial function and common carotid artery wall thickening in patients with essential hypertension. Hypertension. 1998 Jul;32(1):25–32. doi: 10.1161/01.hyp.32.1.25. [DOI] [PubMed] [Google Scholar]
  7. Gibbons G. H., Dzau V. J. The emerging concept of vascular remodeling. N Engl J Med. 1994 May 19;330(20):1431–1438. doi: 10.1056/NEJM199405193302008. [DOI] [PubMed] [Google Scholar]
  8. Girerd X., Mourad J. J., Copie X., Moulin C., Acar C., Safar M., Laurent S. Noninvasive detection of an increased vascular mass in untreated hypertensive patients. Am J Hypertens. 1994 Dec;7(12):1076–1084. doi: 10.1093/ajh/7.12.1076. [DOI] [PubMed] [Google Scholar]
  9. Gregg A. R., Schauer A., Shi O., Liu Z., Lee C. G., O'Brien W. E. Limb reduction defects in endothelial nitric oxide synthase-deficient mice. Am J Physiol. 1998 Dec;275(6 Pt 2):H2319–H2324. doi: 10.1152/ajpheart.1998.275.6.H2319. [DOI] [PubMed] [Google Scholar]
  10. Guzman R. J., Abe K., Zarins C. K. Flow-induced arterial enlargement is inhibited by suppression of nitric oxide synthase activity in vivo. Surgery. 1997 Aug;122(2):273–280. doi: 10.1016/s0039-6060(97)90018-0. [DOI] [PubMed] [Google Scholar]
  11. Gödecke A., Decking U. K., Ding Z., Hirchenhain J., Bidmon H. J., Gödecke S., Schrader J. Coronary hemodynamics in endothelial NO synthase knockout mice. Circ Res. 1998 Feb 9;82(2):186–194. doi: 10.1161/01.res.82.2.186. [DOI] [PubMed] [Google Scholar]
  12. Harrison D. G. Cellular and molecular mechanisms of endothelial cell dysfunction. J Clin Invest. 1997 Nov 1;100(9):2153–2157. doi: 10.1172/JCI119751. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Heagerty A. M., Aalkjaer C., Bund S. J., Korsgaard N., Mulvany M. J. Small artery structure in hypertension. Dual processes of remodeling and growth. Hypertension. 1993 Apr;21(4):391–397. doi: 10.1161/01.hyp.21.4.391. [DOI] [PubMed] [Google Scholar]
  14. Huang P. L., Huang Z., Mashimo H., Bloch K. D., Moskowitz M. A., Bevan J. A., Fishman M. C. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 1995 Sep 21;377(6546):239–242. doi: 10.1038/377239a0. [DOI] [PubMed] [Google Scholar]
  15. Hunt S. C., Williams C. S., Sharma A. M., Inoue I., Williams R. R., Lalouel J. M. Lack of linkage between the endothelial nitric oxide synthase gene and hypertension. J Hum Hypertens. 1996 Jan;10(1):27–30. [PubMed] [Google Scholar]
  16. Kamiya A., Togawa T. Adaptive regulation of wall shear stress to flow change in the canine carotid artery. Am J Physiol. 1980 Jul;239(1):H14–H21. doi: 10.1152/ajpheart.1980.239.1.H14. [DOI] [PubMed] [Google Scholar]
  17. Lacolley P., Gautier S., Poirier O., Pannier B., Cambien F., Benetos A. Nitric oxide synthase gene polymorphisms, blood pressure and aortic stiffness in normotensive and hypertensive subjects. J Hypertens. 1998 Jan;16(1):31–35. doi: 10.1097/00004872-199816010-00006. [DOI] [PubMed] [Google Scholar]
  18. Langille B. L., O'Donnell F. Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent. Science. 1986 Jan 24;231(4736):405–407. doi: 10.1126/science.3941904. [DOI] [PubMed] [Google Scholar]
  19. Luvarà G., Pueyo M. E., Philippe M., Mandet C., Savoie F., Henrion D., Michel J. B. Chronic blockade of NO synthase activity induces a proinflammatory phenotype in the arterial wall: prevention by angiotensin II antagonism. Arterioscler Thromb Vasc Biol. 1998 Sep;18(9):1408–1416. doi: 10.1161/01.atv.18.9.1408. [DOI] [PubMed] [Google Scholar]
  20. Mancini G. B., Henry G. C., Macaya C., O'Neill B. J., Pucillo A. L., Carere R. G., Wargovich T. J., Mudra H., Lüscher T. F., Klibaner M. I. Angiotensin-converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease. The TREND (Trial on Reversing ENdothelial Dysfunction) Study. Circulation. 1996 Aug 1;94(3):258–265. doi: 10.1161/01.cir.94.3.258. [DOI] [PubMed] [Google Scholar]
  21. Miyamoto Y., Saito Y., Kajiyama N., Yoshimura M., Shimasaki Y., Nakayama M., Kamitani S., Harada M., Ishikawa M., Kuwahara K. Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension. 1998 Jul;32(1):3–8. doi: 10.1161/01.hyp.32.1.3. [DOI] [PubMed] [Google Scholar]
  22. Moroi M., Zhang L., Yasuda T., Virmani R., Gold H. K., Fishman M. C., Huang P. L. Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice. J Clin Invest. 1998 Mar 15;101(6):1225–1232. doi: 10.1172/JCI1293. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Numaguchi K., Egashira K., Takemoto M., Kadokami T., Shimokawa H., Sueishi K., Takeshita A. Chronic inhibition of nitric oxide synthesis causes coronary microvascular remodeling in rats. Hypertension. 1995 Dec;26(6 Pt 1):957–962. doi: 10.1161/01.hyp.26.6.957. [DOI] [PubMed] [Google Scholar]
  24. Papapetropoulos A., García-Cardeña G., Madri J. A., Sessa W. C. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest. 1997 Dec 15;100(12):3131–3139. doi: 10.1172/JCI119868. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Rudic R. D., Shesely E. G., Maeda N., Smithies O., Segal S. S., Sessa W. C. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest. 1998 Feb 15;101(4):731–736. doi: 10.1172/JCI1699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Shesely E. G., Maeda N., Kim H. S., Desai K. M., Krege J. H., Laubach V. E., Sherman P. A., Sessa W. C., Smithies O. Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13176–13181. doi: 10.1073/pnas.93.23.13176. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Shimasaki Y., Yasue H., Yoshimura M., Nakayama M., Kugiyama K., Ogawa H., Harada E., Masuda T., Koyama W., Saito Y. Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction. J Am Coll Cardiol. 1998 Jun;31(7):1506–1510. doi: 10.1016/s0735-1097(98)00167-3. [DOI] [PubMed] [Google Scholar]
  28. Taddei S., Virdis A., Mattei P., Ghiadoni L., Sudano I., Salvetti A. Defective L-arginine-nitric oxide pathway in offspring of essential hypertensive patients. Circulation. 1996 Sep 15;94(6):1298–1303. doi: 10.1161/01.cir.94.6.1298. [DOI] [PubMed] [Google Scholar]
  29. Treasure C. B., Klein J. L., Weintraub W. S., Talley J. D., Stillabower M. E., Kosinski A. S., Zhang J., Boccuzzi S. J., Cedarholm J. C., Alexander R. W. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med. 1995 Feb 23;332(8):481–487. doi: 10.1056/NEJM199502233320801. [DOI] [PubMed] [Google Scholar]
  30. Tronc F., Wassef M., Esposito B., Henrion D., Glagov S., Tedgui A. Role of NO in flow-induced remodeling of the rabbit common carotid artery. Arterioscler Thromb Vasc Biol. 1996 Oct;16(10):1256–1262. doi: 10.1161/01.atv.16.10.1256. [DOI] [PubMed] [Google Scholar]
  31. Wang X. L., Mahaney M. C., Sim A. S., Wang J., Wang J., Blangero J., Almasy L., Badenhop R. B., Wilcken D. E. Genetic contribution of the endothelial constitutive nitric oxide synthase gene to plasma nitric oxide levels. Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):3147–3153. doi: 10.1161/01.atv.17.11.3147. [DOI] [PubMed] [Google Scholar]
  32. Wang X. L., Sim A. S., Badenhop R. F., McCredie R. M., Wilcken D. E. A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Nat Med. 1996 Jan;2(1):41–45. doi: 10.1038/nm0196-41. [DOI] [PubMed] [Google Scholar]
  33. Yoshimura M., Yasue H., Nakayama M., Shimasaki Y., Sumida H., Sugiyama S., Kugiyama K., Ogawa H., Ogawa Y., Saito Y. A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese. Hum Genet. 1998 Jul;103(1):65–69. doi: 10.1007/s004390050785. [DOI] [PubMed] [Google Scholar]
  34. Ziche M., Morbidelli L., Masini E., Amerini S., Granger H. J., Maggi C. A., Geppetti P., Ledda F. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J Clin Invest. 1994 Nov;94(5):2036–2044. doi: 10.1172/JCI117557. [DOI] [PMC free article] [PubMed] [Google Scholar]

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