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. 1999 Mar;64(3):776–787. doi: 10.1086/302287

Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36.

M Gibbs 1, J L Stanford 1, R A McIndoe 1, G P Jarvik 1, S Kolb 1, E L Goode 1, L Chakrabarti 1, E F Schuster 1, V A Buckley 1, E L Miller 1, S Brandzel 1, S Li 1, L Hood 1, E A Ostrander 1
PMCID: PMC1377795  PMID: 10053012

Abstract

Combining data from a genomic screen in 70 families with a high risk for prostate cancer (PC) with data from candidate-region mapping in these families and an additional 71 families, we have localized a potential hereditary PC-susceptibility locus to chromosome 1p36. Because an excess of cases of primary brain cancer (BC) have been observed in some studies of families with a high risk for PC, and because loss of heterozygosity at 1p36 is frequently observed in BC, we further evaluated 12 families with both a history of PC and a blood relative with primary BC. The overall LOD score in these 12 families was 3.22 at a recombination fraction (theta) of .06, with marker D1S507. On the basis of an a priori hypothesis, this group was stratified by age at diagnosis of PC. In the younger age group (mean age at diagnosis <66 years), a maximum two-point LOD score of 3.65 at straight theta = .0 was observed, with D1S407. This linkage was rejected in both early- and late-onset families without a history of BC (LOD scores -7.12 and -6.03, respectively, at straight theta = .0). After exclusion of 3 of the 12 families that had better evidence of linkage to previously described PC-susceptibility loci, linkage to the 1p36 region was suggested by a two-point LOD score of 4.74 at straight theta = .0, with marker D1S407. We conclude that a significant proportion of these families with both a high risk for PC and a family member with BC show linkage to the 1p36 region.

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Selected References

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