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. 1999 May;64(5):1276–1281. doi: 10.1086/302392

Repair of mtDNA in vertebrates.

D F Bogenhagen 1
PMCID: PMC1377862  PMID: 10205257

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Selected References

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  1. Backer J. M., Weinstein I. B. Mitochondrial DNA is a major cellular target for a dihydrodiol-epoxide derivative of benzo[a]pyrene. Science. 1980 Jul 11;209(4453):297–299. doi: 10.1126/science.6770466. [DOI] [PubMed] [Google Scholar]
  2. Berdal K. G., Johansen R. F., Seeberg E. Release of normal bases from intact DNA by a native DNA repair enzyme. EMBO J. 1998 Jan 15;17(2):363–367. doi: 10.1093/emboj/17.2.363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bohr V. A., Smith C. A., Okumoto D. S., Hanawalt P. C. DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall. Cell. 1985 Feb;40(2):359–369. doi: 10.1016/0092-8674(85)90150-3. [DOI] [PubMed] [Google Scholar]
  4. Clayton D. A., Doda J. N., Friedberg E. C. The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria. Proc Natl Acad Sci U S A. 1974 Jul;71(7):2777–2781. doi: 10.1073/pnas.71.7.2777. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Croteau D. L., ap Rhys C. M., Hudson E. K., Dianov G. L., Hansford R. G., Bohr V. A. An oxidative damage-specific endonuclease from rat liver mitochondria. J Biol Chem. 1997 Oct 24;272(43):27338–27344. doi: 10.1074/jbc.272.43.27338. [DOI] [PubMed] [Google Scholar]
  6. Cullinane C., Bohr V. A. DNA interstrand cross-links induced by psoralen are not repaired in mammalian mitochondria. Cancer Res. 1998 Apr 1;58(7):1400–1404. [PubMed] [Google Scholar]
  7. Driggers W. J., LeDoux S. P., Wilson G. L. Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells. J Biol Chem. 1993 Oct 15;268(29):22042–22045. [PubMed] [Google Scholar]
  8. Frank K. M., Sekiguchi J. M., Seidl K. J., Swat W., Rathbun G. A., Cheng H. L., Davidson L., Kangaloo L., Alt F. W. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature. 1998 Nov 12;396(6707):173–177. doi: 10.1038/24172. [DOI] [PubMed] [Google Scholar]
  9. Grollman A. P., Moriya M. Mutagenesis by 8-oxoguanine: an enemy within. Trends Genet. 1993 Jul;9(7):246–249. doi: 10.1016/0168-9525(93)90089-z. [DOI] [PubMed] [Google Scholar]
  10. Helbock H. J., Beckman K. B., Shigenaga M. K., Walter P. B., Woodall A. A., Yeo H. C., Ames B. N. DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):288–293. doi: 10.1073/pnas.95.1.288. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kang D., Nishida J., Iyama A., Nakabeppu Y., Furuichi M., Fujiwara T., Sekiguchi M., Takeshige K. Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria. J Biol Chem. 1995 Jun 16;270(24):14659–14665. doi: 10.1074/jbc.270.24.14659. [DOI] [PubMed] [Google Scholar]
  12. LeDoux S. P., Wilson G. L., Beecham E. J., Stevnsner T., Wassermann K., Bohr V. A. Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells. Carcinogenesis. 1992 Nov;13(11):1967–1973. doi: 10.1093/carcin/13.11.1967. [DOI] [PubMed] [Google Scholar]
  13. Lindahl T. Instability and decay of the primary structure of DNA. Nature. 1993 Apr 22;362(6422):709–715. doi: 10.1038/362709a0. [DOI] [PubMed] [Google Scholar]
  14. Longley M. J., Prasad R., Srivastava D. K., Wilson S. H., Copeland W. C. Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12244–12248. doi: 10.1073/pnas.95.21.12244. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Martin N. C., Hopper A. K. How single genes provide tRNA processing enzymes to mitochondria, nuclei and the cytosol. Biochimie. 1994;76(12):1161–1167. doi: 10.1016/0300-9084(94)90045-0. [DOI] [PubMed] [Google Scholar]
  16. Matsumoto Y., Kim K. Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair. Science. 1995 Aug 4;269(5224):699–702. doi: 10.1126/science.7624801. [DOI] [PubMed] [Google Scholar]
  17. Mita S., Monnat R. J., Jr, Loeb L. A. Resistance of HeLa cell mitochondrial DNA to mutagenesis by chemical carcinogens. Cancer Res. 1988 Aug 15;48(16):4578–4583. [PubMed] [Google Scholar]
  18. Myers K. A., Saffhill R., O'Connor P. J. Repair of alkylated purines in the hepatic DNA of mitochondria and nuclei in the rat. Carcinogenesis. 1988 Feb;9(2):285–292. doi: 10.1093/carcin/9.2.285. [DOI] [PubMed] [Google Scholar]
  19. Niranjan B. G., Bhat N. K., Avadhani N. G. Preferential attack of mitochondrial DNA by aflatoxin B1 during hepatocarcinogenesis. Science. 1982 Jan 1;215(4528):73–75. doi: 10.1126/science.6797067. [DOI] [PubMed] [Google Scholar]
  20. Pettepher C. C., LeDoux S. P., Bohr V. A., Wilson G. L. Repair of alkali-labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea streptozotocin. J Biol Chem. 1991 Feb 15;266(5):3113–3117. [PubMed] [Google Scholar]
  21. Pinz K. G., Bogenhagen D. F. Efficient repair of abasic sites in DNA by mitochondrial enzymes. Mol Cell Biol. 1998 Mar;18(3):1257–1265. doi: 10.1128/mcb.18.3.1257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Pont-Kingdon G. A., Okada N. A., Macfarlane J. L., Beagley C. T., Wolstenholme D. R., Cavalier-Smith T., Clark-Walker G. D. A coral mitochondrial mutS gene. Nature. 1995 May 11;375(6527):109–111. doi: 10.1038/375109b0. [DOI] [PubMed] [Google Scholar]
  23. Reenan R. A., Kolodner R. D. Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions. Genetics. 1992 Dec;132(4):975–985. doi: 10.1093/genetics/132.4.975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Richter C., Park J. W., Ames B. N. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6465–6467. doi: 10.1073/pnas.85.17.6465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Satoh M. S., Huh N., Rajewsky M. F., Kuroki T. Enzymatic removal of O6-ethylguanine from mitochondrial DNA in rat tissues exposed to N-ethyl-N-nitrosourea in vivo. J Biol Chem. 1988 May 15;263(14):6854–6856. [PubMed] [Google Scholar]
  26. Shen C. C., Wertelecki W., Driggers W. J., LeDoux S. P., Wilson G. L. Repair of mitochondrial DNA damage induced by bleomycin in human cells. Mutat Res. 1995 Jul;337(1):19–23. doi: 10.1016/0921-8777(95)00008-8. [DOI] [PubMed] [Google Scholar]
  27. Shigenaga M. K., Hagen T. M., Ames B. N. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10771–10778. doi: 10.1073/pnas.91.23.10771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Singh G., Maniccia-Bozzo E. Evidence for lack of mitochondrial DNA repair following cis-dichlorodiammineplatinum treatment. Cancer Chemother Pharmacol. 1990;26(2):97–100. doi: 10.1007/BF02897252. [DOI] [PubMed] [Google Scholar]
  29. Slupphaug G., Markussen F. H., Olsen L. C., Aasland R., Aarsaether N., Bakke O., Krokan H. E., Helland D. E. Nuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same gene. Nucleic Acids Res. 1993 Jun 11;21(11):2579–2584. doi: 10.1093/nar/21.11.2579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Snyderwine E. G., Bohr V. A. Gene- and strand-specific damage and repair in Chinese hamster ovary cells treated with 4-nitroquinoline 1-oxide. Cancer Res. 1992 Aug 1;52(15):4183–4189. [PubMed] [Google Scholar]
  31. Takao M., Aburatani H., Kobayashi K., Yasui A. Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage. Nucleic Acids Res. 1998 Jun 15;26(12):2917–2922. doi: 10.1093/nar/26.12.2917. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Tomkinson A. E., Bonk R. T., Linn S. Mitochondrial endonuclease activities specific for apurinic/apyrimidinic sites in DNA from mouse cells. J Biol Chem. 1988 Sep 5;263(25):12532–12537. [PubMed] [Google Scholar]
  33. Vanderstraeten S., Van den Brûle S., Hu J., Foury F. The role of 3'-5' exonucleolytic proofreading and mismatch repair in yeast mitochondrial DNA error avoidance. J Biol Chem. 1998 Sep 11;273(37):23690–23697. doi: 10.1074/jbc.273.37.23690. [DOI] [PubMed] [Google Scholar]
  34. Wei Y. F., Robins P., Carter K., Caldecott K., Pappin D. J., Yu G. L., Wang R. P., Shell B. K., Nash R. A., Schär P. Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination. Mol Cell Biol. 1995 Jun;15(6):3206–3216. doi: 10.1128/mcb.15.6.3206. [DOI] [PMC free article] [PubMed] [Google Scholar]

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