Skip to main content
PMC home page
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1999 Sep;65(3):587–592. doi: 10.1086/302560

Candidate-gene association studies of schizophrenia.

M C O'Donovan 1, M J Owen 1
PMCID: PMC1377963  PMID: 10441563

Full Text

The Full Text of this article is available as a PDF (173.2 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Austin C. P., Holder D. J., Ma L., Mixson L. A., Caskey C. T. Mapping of hKCa3 to chromosome 1q21 and investigation of linkage of CAG repeat polymorphism to schizophrenia. Mol Psychiatry. 1999 May;4(3):261–266. doi: 10.1038/sj.mp.4000548. [DOI] [PubMed] [Google Scholar]
  2. Bonnet-Brilhault F., Laurent C., Campion D., Thibaut F., Lafargue C., Charbonnier F., Deleuze J. F., Ménard J. F., Jay M., Petit M. No evidence for involvement of KCNN3 (hSKCa3) potassium channel gene in familial and isolated cases of schizophrenia. Eur J Hum Genet. 1999 Feb-Mar;7(2):247–250. doi: 10.1038/sj.ejhg.5200278. [DOI] [PubMed] [Google Scholar]
  3. Bowen T., Guy C. A., Craddock N., Cardno A. G., Williams N. M., Spurlock G., Murphy K. C., Jones L. A., Gray M., Sanders R. D. Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia. Mol Psychiatry. 1998 May;3(3):266–269. doi: 10.1038/sj.mp.4000400. [DOI] [PubMed] [Google Scholar]
  4. Bunzel R., Blümcke I., Cichon S., Normann S., Schramm J., Propping P., Nöthen M. M. Polymorphic imprinting of the serotonin-2A (5-HT2A) receptor gene in human adult brain. Brain Res Mol Brain Res. 1998 Aug 15;59(1):90–92. doi: 10.1016/s0169-328x(98)00146-6. [DOI] [PubMed] [Google Scholar]
  5. Chandy K. G., Fantino E., Wittekindt O., Kalman K., Tong L. L., Ho T. H., Gutman G. A., Crocq M. A., Ganguli R., Nimgaonkar V. Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder? Mol Psychiatry. 1998 Jan;3(1):32–37. doi: 10.1038/sj.mp.4000353. [DOI] [PubMed] [Google Scholar]
  6. Crocq M. A., Mant R., Asherson P., Williams J., Hode Y., Mayerova A., Collier D., Lannfelt L., Sokoloff P., Schwartz J. C. Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. J Med Genet. 1992 Dec;29(12):858–860. doi: 10.1136/jmg.29.12.858. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dror V., Shamir E., Ghanshani S., Kimhi R., Swartz M., Barak Y., Weizman R., Avivi L., Litmanovitch T., Fantino E. hKCa3/KCNN3 potassium channel gene: association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21. Mol Psychiatry. 1999 May;4(3):254–260. doi: 10.1038/sj.mp.4000508. [DOI] [PubMed] [Google Scholar]
  8. Inayama Y., Yoneda H., Sakai T., Ishida T., Nonomura Y., Kono Y., Takahata R., Koh J., Sakai J., Takai A. Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia. Am J Med Genet. 1996 Feb 16;67(1):103–105. doi: 10.1002/(SICI)1096-8628(19960216)67:1<103::AID-AJMG18>3.0.CO;2-S. [DOI] [PubMed] [Google Scholar]
  9. Joober R., Benkelfat C., Brisebois K., Toulouse A., Lafrenière R. G., Turecki G., Lal S., Bloom D., Labelle A., Lalonde P. Lack of association between the hSKCa3 channel gene CAG polymorphism and schizophrenia. Am J Med Genet. 1999 Apr 16;88(2):154–157. [PubMed] [Google Scholar]
  10. Laurent C., Zander C., Thibaut F., Bonnet-Brilhault F., Chavand O., Jay M., Samolyk D., Petit M., Martinez M., Campion D. Anticipation in schizophrenia: no evidence of expanded CAG/CTG repeat sequences in French families and sporadic cases. Am J Med Genet. 1998 Jul 10;81(4):342–346. doi: 10.1002/(sici)1096-8628(19980710)81:4<342::aid-ajmg12>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  11. Li T., Hu X., Chandy K. G., Fantino E., Kalman K., Gutman G., Gargus J. J., Freeman B., Murray R. M., Dawson E. Transmission disequilibrium analysis of a triplet repeat within the hKCa3 gene using family trios with schizophrenia. Biochem Biophys Res Commun. 1998 Oct 20;251(2):662–665. doi: 10.1006/bbrc.1998.9484. [DOI] [PubMed] [Google Scholar]
  12. Li T., Vallada H. P., Liu X., Xie T., Tang X., Zhao J., O'Donovan M. C., Murray R. M., Sham P. C., Collier D. A. Analysis of CAG/CTG repeat size in Chinese subjects with schizophrenia and bipolar affective disorder using the repeat expansion detection method. Biol Psychiatry. 1998 Dec 1;44(11):1160–1165. doi: 10.1016/s0006-3223(97)00492-7. [DOI] [PubMed] [Google Scholar]
  13. Lindblad K., Nylander P. O., Zander C., Yuan Q. P., Ståhle L., Engström C., Balciuniene J., Pettersson U., Breschel T., McInnis M. Two commonly expanded CAG/CTG repeat loci: involvement in affective disorders? Mol Psychiatry. 1998 Sep;3(5):405–410. doi: 10.1038/sj.mp.4000416. [DOI] [PubMed] [Google Scholar]
  14. McGue M., Gottesman I. I. A single dominant gene still cannot account for the transmission of schizophrenia. Arch Gen Psychiatry. 1989 May;46(5):478–480. doi: 10.1001/archpsyc.1989.01810050092016. [DOI] [PubMed] [Google Scholar]
  15. McGuffin P., Owen M. J., Farmer A. E. Genetic basis of schizophrenia. Lancet. 1995 Sep 9;346(8976):678–682. doi: 10.1016/s0140-6736(95)92285-7. [DOI] [PubMed] [Google Scholar]
  16. O'Donovan M. C., Guy C., Craddock N., Bowen T., McKeon P., Macedo A., Maier W., Wildenauer D., Aschauer H. N., Sorbi S. Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder. Psychol Med. 1996 Nov;26(6):1145–1153. doi: 10.1017/s0033291700035868. [DOI] [PubMed] [Google Scholar]
  17. O'Donovan M. C., Guy C., Craddock N., Murphy K. C., Cardno A. G., Jones L. A., Owen M. J., McGuffin P. Expanded CAG repeats in schizophrenia and bipolar disorder. Nat Genet. 1995 Aug;10(4):380–381. doi: 10.1038/ng0895-380. [DOI] [PubMed] [Google Scholar]
  18. O'Donovan M. C., Owen M. J. Dynamic mutations and psychiatric genetics. Psychol Med. 1996 Jan;26(1):1–6. doi: 10.1017/s0033291700033663. [DOI] [PubMed] [Google Scholar]
  19. Owen M. J., Holmans P., McGuffin P. Association studies in psychiatric genetics. Mol Psychiatry. 1997 Jul;2(4):270–273. doi: 10.1038/sj.mp.4000292. [DOI] [PubMed] [Google Scholar]
  20. Petronis A., Kennedy J. L. Unstable genes--unstable mind? Am J Psychiatry. 1995 Feb;152(2):164–172. doi: 10.1176/ajp.152.2.164. [DOI] [PubMed] [Google Scholar]
  21. Risch N. Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet. 1990 Feb;46(2):222–228. [PMC free article] [PubMed] [Google Scholar]
  22. Risch N., Merikangas K. The future of genetic studies of complex human diseases. Science. 1996 Sep 13;273(5281):1516–1517. doi: 10.1126/science.273.5281.1516. [DOI] [PubMed] [Google Scholar]
  23. Risch N., Teng J. The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases I. DNA pooling. Genome Res. 1998 Dec;8(12):1273–1288. doi: 10.1101/gr.8.12.1273. [DOI] [PubMed] [Google Scholar]
  24. Ross C. A. Schizophrenia genetics: expansion of knowledge? Mol Psychiatry. 1999 Jan;4(1):4–5. doi: 10.1038/sj.mp.4000502. [DOI] [PubMed] [Google Scholar]
  25. Schaid D. J., Sommer S. S. Comparison of statistics for candidate-gene association studies using cases and parents. Am J Hum Genet. 1994 Aug;55(2):402–409. [PMC free article] [PubMed] [Google Scholar]
  26. Sidransky E., Burgess C., Ikeuchi T., Lindblad K., Long R. T., Philibert R. A., Rapoport J., Schalling M., Tsuji S., Ginns E. I. A triplet repeat on 17q accounts for most expansions detected by the repeat-expansion-detection technique. Am J Hum Genet. 1998 Jun;62(6):1548–1551. doi: 10.1086/301876. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Spurlock G., Heils A., Holmans P., Williams J., D'Souza U. M., Cardno A., Murphy K. C., Jones L., Buckland P. R., McGuffin P. A family based association study of T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphisms in the promoter. Mol Psychiatry. 1998 Jan;3(1):42–49. doi: 10.1038/sj.mp.4000342. [DOI] [PubMed] [Google Scholar]
  28. Stöber G., Jatzke S., Meyer J., Okladnova O., Knapp M., Beckmann H., Lesch K. P. Short CAG repeats within the hSKCa3 gene associated with schizophrenia: results of a family-based study. Neuroreport. 1998 Nov 16;9(16):3595–3599. doi: 10.1097/00001756-199811160-00010. [DOI] [PubMed] [Google Scholar]
  29. Tsai M. T., Shaw C. K., Hsiao K. J., Chen C. H. Genetic association study of a polymorphic CAG repeats array of calcium-activated potassium channel (KCNN3) gene and schizophrenia among the Chinese population from Taiwan. Mol Psychiatry. 1999 May;4(3):271–273. doi: 10.1038/sj.mp.4000482. [DOI] [PubMed] [Google Scholar]
  30. Vincent J. B., Petronis A., Strong E., Parikh S. V., Meltzer H. Y., Lieberman J., Kennedy J. L. Analysis of genome-wide CAG/CTG repeats, and at SEF2-1B and ERDA1 in schizophrenia and bipolar affective disorder. Mol Psychiatry. 1999 May;4(3):229–234. doi: 10.1038/sj.mp.4000498. [DOI] [PubMed] [Google Scholar]
  31. Williams J., McGuffin P., Nöthen M., Owen M. J. Meta-analysis of association between the 5-HT2a receptor T102C polymorphism and schizophrenia. EMASS Collaborative Group. European Multicentre Association Study of Schizophrenia. Lancet. 1997 Apr 26;349(9060):1221–1221. doi: 10.1016/s0140-6736(05)62413-0. [DOI] [PubMed] [Google Scholar]
  32. Williams J., Spurlock G., Holmans P., Mant R., Murphy K., Jones L., Cardno A., Asherson P., Blackwood D., Muir W. A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia. Mol Psychiatry. 1998 Mar;3(2):141–149. doi: 10.1038/sj.mp.4000376. [DOI] [PubMed] [Google Scholar]
  33. Williams J., Spurlock G., McGuffin P., Mallet J., Nöthen M. M., Gill M., Aschauer H., Nylander P. O., Macciardi F., Owen M. J. Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. European Multicentre Association Study of Schizophrenia (EMASS) Group. Lancet. 1996 May 11;347(9011):1294–1296. doi: 10.1016/s0140-6736(96)90939-3. [DOI] [PubMed] [Google Scholar]
  34. Wittekindt O., Schwab S. G., Burgert E., Knapp M., Albus M., Lerer B., Hallmayer J., Rietschel M., Segman R., Borrmann M. Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios. Mol Psychiatry. 1999 May;4(3):267–270. doi: 10.1038/sj.mp.4000495. [DOI] [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES